JP2019522973A5 - - Google Patents
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- JP2019522973A5 JP2019522973A5 JP2018567062A JP2018567062A JP2019522973A5 JP 2019522973 A5 JP2019522973 A5 JP 2019522973A5 JP 2018567062 A JP2018567062 A JP 2018567062A JP 2018567062 A JP2018567062 A JP 2018567062A JP 2019522973 A5 JP2019522973 A5 JP 2019522973A5
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- antigen recognition
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- 239000000427 antigen Substances 0.000 claims 45
- 102000036639 antigens Human genes 0.000 claims 45
- 108091007433 antigens Proteins 0.000 claims 45
- 210000004027 cell Anatomy 0.000 claims 34
- -1 NY-ES0-1 Proteins 0.000 claims 20
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 15
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 15
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 14
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 14
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 12
- 102000010956 Glypican Human genes 0.000 claims 12
- 108050001154 Glypican Proteins 0.000 claims 12
- 108050007237 Glypican-3 Proteins 0.000 claims 12
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 12
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 12
- 230000000139 costimulatory effect Effects 0.000 claims 12
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 11
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 11
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 9
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 9
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 9
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 9
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 9
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 9
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 9
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 9
- 102100035721 Syndecan-1 Human genes 0.000 claims 9
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 8
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 8
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 8
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 8
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 7
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 7
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 6
- 102100022749 Aminopeptidase N Human genes 0.000 claims 6
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 6
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 6
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 6
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 6
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 6
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims 6
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims 6
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims 6
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 6
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 6
- 102100032999 Integrin beta-3 Human genes 0.000 claims 6
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 6
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 6
- 102100025136 Macrosialin Human genes 0.000 claims 6
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 6
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 6
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 6
- 101710181056 Tumor necrosis factor ligand superfamily member 13B Proteins 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 5
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 5
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims 4
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims 4
- 102100028801 Calsyntenin-1 Human genes 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims 4
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 102000016605 B-Cell Activating Factor Human genes 0.000 claims 3
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 210000000581 natural killer T-cell Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
- 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 1
- 208000001715 Osteoblastoma Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 102100024304 Protachykinin-1 Human genes 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000025750 heavy chain disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 208000010626 plasma cell neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2016/039306 WO2016210293A1 (en) | 2015-06-25 | 2016-06-24 | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| USPCT/US2016/039306 | 2016-06-24 | ||
| US201662369004P | 2016-07-29 | 2016-07-29 | |
| US62/369,004 | 2016-07-29 | ||
| PCT/US2016/068349 WO2017222593A1 (en) | 2016-06-24 | 2016-12-22 | Chimeric antigen receptors (cars), compositions and methods thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522973A JP2019522973A (ja) | 2019-08-22 |
| JP2019522973A5 true JP2019522973A5 (enExample) | 2020-02-06 |
| JP7114490B2 JP7114490B2 (ja) | 2022-08-08 |
Family
ID=60783276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567062A Active JP7114490B2 (ja) | 2016-06-24 | 2016-12-22 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20200283534A1 (enExample) |
| EP (2) | EP4353750A3 (enExample) |
| JP (1) | JP7114490B2 (enExample) |
| CN (1) | CN109562126A (enExample) |
| CA (1) | CA3029197A1 (enExample) |
| WO (1) | WO2017222593A1 (enExample) |
Families Citing this family (133)
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| EP3240805B1 (en) | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
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| US20220241327A1 (en) * | 2015-06-25 | 2022-08-04 | Icell Gene Therapeutics Llc | Chimeric Antigen Receptor (CAR) Targeting Multiple Antigens, Compositions and Methods of Use Thereof |
| US20220348633A1 (en) * | 2015-06-25 | 2022-11-03 | Icell Gene Therapeutics Llc | COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHOD OF USE THEREOF |
| EP3368077A4 (en) | 2015-10-30 | 2019-10-16 | Aleta Biotherapeutics Inc. | COMPOSITIONS AND METHODS FOR TUMOR TRANSDUCTION |
| EP3368559A4 (en) | 2015-10-30 | 2020-01-15 | Aleta Biotherapeutics Inc. | COMPOSITIONS AND METHODS FOR TREATING CANCER |
| US11384156B2 (en) * | 2016-07-25 | 2022-07-12 | The Nemours Foundation | Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases |
| JP7193862B2 (ja) | 2016-08-03 | 2022-12-21 | ワシントン・ユニバーシティ | キメラ抗原受容体でのｔ細胞性悪性腫瘍の治療のためのｃａｒ－ｔ細胞の遺伝子編集 |
| EP3506943B1 (en) | 2016-09-02 | 2025-01-29 | The Regents of The University of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| AU2017357649A1 (en) * | 2016-11-11 | 2019-05-23 | Autolus Limited | Chimeric antigen receptor |
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| US12473342B2 (en) | 2018-04-27 | 2025-11-18 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis |
| US20210094994A1 (en) * | 2018-04-27 | 2021-04-01 | Baylor College Of Medicine | Car t cells with one or more interleukins |
| CN110468105B (zh) * | 2018-05-09 | 2024-03-22 | 恺兴生命科技(上海)有限公司 | 表达il-18r结合蛋白的免疫效应细胞 |
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2016
- 2016-12-22 US US16/312,769 patent/US20200283534A1/en not_active Abandoned
- 2016-12-22 CN CN201680087034.6A patent/CN109562126A/zh active Pending
- 2016-12-22 EP EP23220747.2A patent/EP4353750A3/en not_active Withdrawn
- 2016-12-22 WO PCT/US2016/068349 patent/WO2017222593A1/en not_active Ceased
- 2016-12-22 EP EP16906492.0A patent/EP3474867A4/en active Pending
- 2016-12-22 CA CA3029197A patent/CA3029197A1/en active Pending
- 2016-12-22 JP JP2018567062A patent/JP7114490B2/ja active Active
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2017
- 2017-06-21 US US15/538,620 patent/US11820819B2/en active Active
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2022
- 2022-08-01 US US17/878,339 patent/US20230340113A1/en active Pending
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2023
- 2023-10-13 US US18/379,708 patent/US20240141041A1/en active Pending
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