|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8725529D0
(en)
|
1987-10-30 |
1987-12-02 |
Delta Biotechnology Ltd |
Polypeptides
|
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
DE59010908D1
(de)
|
1989-09-12 |
2000-08-10 |
Hoffmann La Roche |
TNF-bindende Proteine
|
|
US5503978A
(en)
|
1990-06-11 |
1996-04-02 |
University Research Corporation |
Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
|
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
|
US5543293A
(en)
|
1990-06-11 |
1996-08-06 |
Nexstar Pharmaceuticals, Inc. |
DNA ligands of thrombin
|
|
US6319494B1
(en)
|
1990-12-14 |
2001-11-20 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
ES2134212T3
(es)
|
1991-04-25 |
1999-10-01 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US5138941A
(en)
|
1991-06-28 |
1992-08-18 |
Strauss Frederick J |
Wooden crusher for recyclable metal cans
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
IL104570A0
(en)
|
1992-03-18 |
1993-05-13 |
Yeda Res & Dev |
Chimeric genes and cells transformed therewith
|
|
AU5670194A
(en)
|
1992-11-20 |
1994-06-22 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
US5631146A
(en)
|
1995-01-19 |
1997-05-20 |
The General Hospital Corporation |
DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof
|
|
JP2002510968A
(ja)
|
1997-05-07 |
2002-04-09 |
ブリストル−マイヤーズ スクイブ カンパニー |
組換え抗体−酵素融合タンパク質
|
|
EP1025212B1
(en)
|
1997-10-14 |
2007-09-26 |
Darwin Molecular Corporation |
Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities
|
|
US6492497B1
(en)
|
1999-04-30 |
2002-12-10 |
Cambridge Antibody Technology Limited |
Specific binding members for TGFbeta1
|
|
US20090257994A1
(en)
|
2001-04-30 |
2009-10-15 |
City Of Hope |
Chimeric immunoreceptor useful in treating human cancers
|
|
US7066469B2
(en)
|
2002-08-06 |
2006-06-27 |
University of Kentucky Research Foundation Board of Supervisors of Louisiana State University |
Seal assembly for machinery housing
|
|
US20040043949A1
(en)
|
2002-08-30 |
2004-03-04 |
Christopher Richardson |
Therapeutic system targeting pathogen proteases and uses thereof
|
|
UA80296C2
(en)
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Imidazolopyridines and methods of making and using the same
|
|
US20050129671A1
(en)
|
2003-03-11 |
2005-06-16 |
City Of Hope |
Mammalian antigen-presenting T cells and bi-specific T cells
|
|
US7767788B2
(en)
|
2003-03-21 |
2010-08-03 |
The Research Foundation Of State University Of New York |
Folding protein functioning as a molecular switch
|
|
WO2005000200A2
(en)
*
|
2003-05-09 |
2005-01-06 |
Sugen, Inc. |
Novel kinases
|
|
EP1638510B1
(en)
|
2003-07-01 |
2015-09-02 |
Immunomedics, Inc. |
Multivalent carriers of bi-specific antibodies
|
|
US7754209B2
(en)
|
2003-07-26 |
2010-07-13 |
Trubion Pharmaceuticals |
Binding constructs and methods for use thereof
|
|
JP2007521315A
(ja)
|
2003-08-01 |
2007-08-02 |
アムジェン インコーポレイテッド |
結晶性腫瘍壊死因子レセプター2ポリペプチド
|
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
|
KR20060127409A
(ko)
|
2003-11-13 |
2006-12-12 |
제넨테크, 인크. |
종양 치료 방법 및 스크리닝 검정
|
|
CA2561686C
(en)
*
|
2004-03-31 |
2014-12-02 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
EP1810980A1
(en)
|
2004-10-28 |
2007-07-25 |
Osaka University |
Interleukin-6 inhibitors
|
|
CN101163502A
(zh)
|
2005-02-08 |
2008-04-16 |
根茨美公司 |
针对TGFβ的抗体
|
|
US20090068158A1
(en)
|
2005-12-09 |
2009-03-12 |
Medin Jeffrey A |
Thymidylate kinase mutants and uses thereof
|
|
WO2007070866A2
(en)
|
2005-12-16 |
2007-06-21 |
Alcon, Inc. |
Control of intraocular pressure using alk5 modulation agents
|
|
JP2010535487A
(ja)
*
|
2007-08-03 |
2010-11-25 |
アステリオン・リミテッド |
顆粒球コロニー刺激因子
|
|
EP2310416A1
(en)
|
2008-06-30 |
2011-04-20 |
Morphotek, Inc. |
Anti-gd2 antibodies and methods and uses related thereto
|
|
US8822647B2
(en)
|
2008-08-26 |
2014-09-02 |
City Of Hope |
Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
EP2445530B1
(en)
|
2009-06-24 |
2016-09-07 |
The Feinstein Institute for Medical Research |
Method for treating chronic lymphocytic leukemia
|
|
CA2764729C
(en)
|
2009-06-26 |
2019-04-02 |
Sea Lane Biotechnologies, Llc |
Expression of surrogate light chains
|
|
WO2011140170A1
(en)
|
2010-05-04 |
2011-11-10 |
Yeda Research And Development Co. Ltd. |
Immunotherapy using redirected allogeneic cells
|
|
US9089520B2
(en)
|
2010-05-21 |
2015-07-28 |
Baylor College Of Medicine |
Methods for inducing selective apoptosis
|
|
MX354535B
(es)
*
|
2010-09-01 |
2018-03-09 |
Genzyme Corp Star |
TRATAMIENTO DE INFARTO DE MIOCARDIO USANDO ANTAGONISTAS DE TGF-ß.
|
|
WO2012033885A1
(en)
|
2010-09-08 |
2012-03-15 |
Baylor College Of Medicine |
Immunotherapy of cancer using genetically engineered gd2-specific t cells
|
|
EP2787007A3
(en)
|
2010-11-08 |
2015-03-11 |
F. Hoffmann-La Roche AG |
Subcutaneously administered ANTI-IL-6 receptor antibody
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
US20130071414A1
(en)
|
2011-04-27 |
2013-03-21 |
Gianpietro Dotti |
Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
|
|
JP5997151B2
(ja)
*
|
2011-06-30 |
2016-09-28 |
中外製薬株式会社 |
ヘテロ二量化ポリペプチド
|
|
JP6441079B2
(ja)
|
2011-12-19 |
2018-12-19 |
シンイミューン ゲーエムベーハー |
二重特異性抗体分子
|
|
EP3594245A1
(en)
|
2012-02-13 |
2020-01-15 |
Seattle Children's Hospital d/b/a Seattle Children's Research Institute |
Bispecific chimeric antigen receptors and therapeutic uses thereof
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
US20130280220A1
(en)
|
2012-04-20 |
2013-10-24 |
Nabil Ahmed |
Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
|
|
AU2013289971A1
(en)
|
2012-07-13 |
2015-01-22 |
The Trustees Of The University Of Pennsylvania |
Enhancing activity of CAR T cells by co-introducing a bispecific antibody
|
|
PL3824905T3
(pl)
|
2012-08-20 |
2025-05-05 |
Fred Hutchinson Cancer Center |
Sposób i kompozycje do immunoterapii komórkowej
|
|
CA3247166A1
(en)
|
2012-10-04 |
2026-03-02 |
Research Development Foundation |
Serine protease molecules and therapies
|
|
KR101911438B1
(ko)
|
2012-10-31 |
2018-10-24 |
삼성전자주식회사 |
이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법
|
|
EP2730289A1
(en)
|
2012-11-07 |
2014-05-14 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Novel immunoproteases
|
|
ES2831374T3
(es)
|
2012-11-21 |
2021-06-08 |
Janssen Biotech Inc |
Anticuerpos de EGFR/c-Met biespecíficos
|
|
WO2014079000A1
(en)
|
2012-11-21 |
2014-05-30 |
Wuhan Yzy Biopharma Co., Ltd. |
Bispecific antibody
|
|
SI3300745T1
(sl)
|
2013-02-15 |
2020-01-31 |
The Regents Of The University Of California |
Himerni antigenski receptor in postopki njihove uporabe
|
|
PL2971048T4
(pl)
*
|
2013-03-11 |
2019-05-31 |
Genzyme Corp |
Zmodyfikowane przeciwciała anty-TGF-beta i fragmenty wiążące antygen
|
|
EP2986636B1
(en)
*
|
2013-04-17 |
2018-11-14 |
Baylor College Of Medicine |
Immunosuppressive tgf-beta signal converter
|
|
US20160333108A1
(en)
|
2014-01-13 |
2016-11-17 |
Stephen J. Forman |
CHIMERIC ANTIGEN RECEPTORS (CARs) HAVING MUTATIONS IN THE FC SPACER REGION AND METHODS FOR THEIR USE
|
|
AU2015216875B2
(en)
|
2014-02-14 |
2021-02-25 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
WO2015128653A2
(en)
|
2014-02-27 |
2015-09-03 |
Ucl Business Plc |
Ligand
|
|
US9944709B2
(en)
*
|
2014-03-19 |
2018-04-17 |
Cellectis |
CD123 specific chimeric antigen receptors for cancer immunotherapy
|
|
CN106795221B
(zh)
*
|
2014-04-03 |
2022-06-07 |
塞勒克提斯公司 |
用于癌症免疫治疗的cd33特异性嵌合抗原受体
|
|
AU2015243849B2
(en)
|
2014-04-10 |
2020-12-17 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Transgene genetic tags and methods of use
|
|
CA2945620C
(en)
*
|
2014-04-14 |
2022-12-06 |
Cellectis |
Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
|
|
KR20170075785A
(ko)
|
2014-11-05 |
2017-07-03 |
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 |
유전자 변형된 면역 효과기 세포 및 면역 효과기 세포의 증식용 가공된 세포
|
|
WO2016090190A1
(en)
|
2014-12-03 |
2016-06-09 |
Juno Therapeutics, Inc. |
Methods and compositions for adoptive cell therapy
|
|
EP3971210A1
(en)
|
2014-12-12 |
2022-03-23 |
2seventy bio, Inc. |
Composition for use in the treatment of b cell related conditions in a subject in need thereof comprisine an effector cell comrising a bcma chimeric antigen receptors
|
|
US11384350B2
(en)
|
2014-12-15 |
2022-07-12 |
The Regents Of The University Of California |
Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
|
|
CA3008162A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
WO2016130598A1
(en)
|
2015-02-09 |
2016-08-18 |
University Of Florida Research Foundation, Inc. |
Bi-specific chimeric antigen receptor and uses thereof
|
|
EP3283113A4
(en)
|
2015-04-15 |
2018-12-05 |
The California Institute for Biomedical Research |
Optimized pne-based chimeric receptor t cell switches and uses thereof
|
|
WO2016174652A1
(en)
|
2015-04-30 |
2016-11-03 |
Technion Research & Development Foundation Limited |
Chimeric antigen receptors and methods of their use
|
|
JP7162530B2
(ja)
|
2015-08-07 |
2022-10-28 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
固形腫瘍を標的とする二重特異性car t細胞
|
|
CN105384825B
(zh)
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
|
DK3368571T5
(da)
*
|
2015-10-30 |
2024-09-30 |
Univ California |
Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf
|
|
MX2018005618A
(es)
|
2015-11-05 |
2018-08-01 |
Juno Therapeutics Inc |
Receptores quimericos que contienen dominios inductores de traf y composiciones y metodos relacionados.
|
|
CN108884140B
(zh)
|
2015-12-03 |
2022-10-25 |
朱诺治疗学股份有限公司 |
修饰的嵌合受体及相关组合物和方法
|
|
WO2017172981A2
(en)
|
2016-03-29 |
2017-10-05 |
University Of Southern California |
Chimeric antigen receptors targeting cancer
|
|
US10603380B2
(en)
|
2016-04-01 |
2020-03-31 |
Kite Pharma, Inc. |
Chimeric antigen and T cell receptors and methods of use
|
|
WO2017180993A1
(en)
|
2016-04-14 |
2017-10-19 |
Bluebird Bio, Inc. |
Salvage chimeric antigen receptor systems
|
|
CN105837693A
(zh)
|
2016-05-30 |
2016-08-10 |
李斯文 |
一种基于bcma的抗原嵌合受体及其制备方法和应用
|
|
JP7114490B2
(ja)
|
2016-06-24 |
2022-08-08 |
アイセル・ジーン・セラピューティクス・エルエルシー |
キメラ抗体受容体(CARs)の構成およびその使用方法
|
|
CA3035615A1
(en)
|
2016-09-02 |
2018-03-08 |
Lentigen Technology, Inc. |
Compositions and methods for treating cancer with duocars
|
|
WO2018067992A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
JP7685735B2
(ja)
|
2016-12-02 |
2025-05-30 |
アンヘレス セラピューティクス インコーポレイテッド |
合成免疫受容体およびその使用方法
|
|
CN108148863B
(zh)
|
2016-12-05 |
2019-12-17 |
上海优卡迪生物医药科技有限公司 |
一种封闭il6r的用于缓解crs的car-t转基因载体及其构建方法和应用
|
|
WO2019028051A1
(en)
|
2017-07-31 |
2019-02-07 |
Lentigen Technology, Inc. |
COMPOSITIONS AND METHODS FOR TREATING CANCER BY ANTI-CD19 / CD20 IMMUNOTHERAPY
|
|
BR112020005938A2
(pt)
|
2017-09-27 |
2020-11-17 |
University Of Southern California |
célula imune ou população de células imunes da mesma, célula efetora imune ou célula-tronco, célula que apresenta antígeno, polinucleotídeo recombinante, vetor, composição que compreende uma célula imune efetora ou uma célula-tronco, métodos para produzir uma célula efetora imune que expressa receptor imune de ocorrência não natural, para gerar uma população de células manipuladas por rna, para fornecer imunidade antidoença em um indivíduo, para tratar ou prevenir uma doença associada à expressão de um antígeno, e, uso
|
|
US20220218745A1
(en)
|
2017-12-22 |
2022-07-14 |
2Seventy Bio, Inc. |
Multivalent chimeric antigen receptor
|
|
KR20200115511A
(ko)
|
2017-12-29 |
2020-10-07 |
시티 오브 호프 |
메디토프-이용 가능한 t 세포
|
|
WO2019134866A1
(en)
|
2018-01-03 |
2019-07-11 |
Molmed Spa |
Chimeric antigen receptors containing optimal spacer region
|
|
IL279063B2
(en)
|
2018-05-31 |
2026-05-01 |
Washington Univ |
Chimeric antigen receptor T cells for cancer treatment
|
|
EP3801301B1
(en)
|
2018-06-08 |
2026-01-28 |
Boston Scientific Scimed Inc. |
Occlusive device with actuatable fixation members
|
|
CN119529091A
(zh)
|
2018-06-19 |
2025-02-28 |
南京传奇生物科技有限公司 |
工程化的细胞及其用途
|
|
US20210269525A1
(en)
|
2018-06-29 |
2021-09-02 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
ANTI-CD3e ANTIBODIES AND USES THEREOF
|
|
WO2020010235A1
(en)
|
2018-07-05 |
2020-01-09 |
H. Lee Moffitt Cancer Center And Research Institute Inc. |
Car t cells that target b-cell antigens
|
|
CA3108778A1
(en)
|
2018-08-06 |
2020-02-13 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods and compositions for stimulation of chimeric antigen receptor t cells with hapten labelled cells
|
|
JP2022512594A
(ja)
|
2018-10-05 |
2022-02-07 |
ザンクト アンナ キンダークレプスフォルシュング |
キメラ抗原受容体(car)の群
|
|
JP2022504191A
(ja)
|
2018-10-05 |
2022-01-13 |
ザンクト アンナ キンダークレプスフォルシュング |
キメラ抗原受容体(car)群
|
|
EP3876977A1
(en)
|
2018-11-06 |
2021-09-15 |
The Regents Of The University Of California |
Chimeric antigen receptors for phagocytosis
|
|
SG11202105380RA
(en)
|
2018-11-30 |
2021-06-29 |
Juno Therapeutics Inc |
Methods for dosing and treatment of b cell malignancies in adoptive cell therapy
|
|
US11793834B2
(en)
|
2018-12-12 |
2023-10-24 |
Kite Pharma, Inc. |
Chimeric antigen and T cell receptors and methods of use
|
|
EP3927735A4
(en)
|
2019-02-18 |
2023-09-06 |
Memorial Sloan Kettering Cancer Center |
COMBINATIONS OF MULTIPLE CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY
|
|
WO2020172641A1
(en)
|
2019-02-21 |
2020-08-27 |
Arbele Limited |
Artificial immunosurveillance chimeric antigen receptor and cells expressing the same
|
|
US11969443B2
(en)
|
2019-03-06 |
2024-04-30 |
Lentigen Technology, Inc. |
Compositions and methods for treating cancer with self-driving chimeric antigen receptors
|
|
AU2020261886A1
(en)
|
2019-04-22 |
2021-11-18 |
Nanjing Legend Biotech Co., Ltd. |
Engineered cells and uses thereof
|
|
CN114450395A
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