CA3029197A1 - Chimeric antigen receptors (cars), compositions and methods thereof - Google Patents

Chimeric antigen receptors (cars), compositions and methods thereof Download PDF

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Publication number
CA3029197A1
CA3029197A1 CA3029197A CA3029197A CA3029197A1 CA 3029197 A1 CA3029197 A1 CA 3029197A1 CA 3029197 A CA3029197 A CA 3029197A CA 3029197 A CA3029197 A CA 3029197A CA 3029197 A1 CA3029197 A1 CA 3029197A1
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Canada
Prior art keywords
cells
cell
engineered
car
antigen recognition
Prior art date
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Pending
Application number
CA3029197A
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English (en)
French (fr)
Inventor
Yupo Ma
Kevin PINZ
Xun JIANG
Masayuki Wada
Kevin Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icell Gene Therapeutics LLC
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Icell Gene Therapeutics LLC
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Filing date
Publication date
Priority claimed from PCT/US2016/039306 external-priority patent/WO2016210293A1/en
Application filed by Icell Gene Therapeutics LLC filed Critical Icell Gene Therapeutics LLC
Publication of CA3029197A1 publication Critical patent/CA3029197A1/en
Pending legal-status Critical Current

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K—PEPTIDES
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/50—Fusion polypeptide containing protease site
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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CA3029197A 2016-06-24 2016-12-22 Chimeric antigen receptors (cars), compositions and methods thereof Pending CA3029197A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
USPCT/US2016/039306 2016-06-24
PCT/US2016/039306 WO2016210293A1 (en) 2015-06-25 2016-06-24 CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
US201662369004P 2016-07-29 2016-07-29
US62/369,004 2016-07-29
PCT/US2016/068349 WO2017222593A1 (en) 2016-06-24 2016-12-22 Chimeric antigen receptors (cars), compositions and methods thereof

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CA3029197A1 true CA3029197A1 (en) 2017-12-28

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CA3029197A Pending CA3029197A1 (en) 2016-06-24 2016-12-22 Chimeric antigen receptors (cars), compositions and methods thereof

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US (4) US20200283534A1 (enExample)
EP (2) EP4353750A3 (enExample)
JP (1) JP7114490B2 (enExample)
CN (1) CN109562126A (enExample)
CA (1) CA3029197A1 (enExample)
WO (1) WO2017222593A1 (enExample)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20250129T1 (hr) 2014-12-15 2025-04-11 The Regents Of The University Of California Bispecifični or-gate kimerni antigenski receptor koji reagira na cd19 i cd20
SG10201913124RA (en) 2015-02-06 2020-03-30 Nat Univ Singapore Methods for enhancing efficacy of therapeutic immune cells
WO2016210293A1 (en) * 2015-06-25 2016-12-29 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
US20220241327A1 (en) * 2015-06-25 2022-08-04 Icell Gene Therapeutics Llc Chimeric Antigen Receptor (CAR) Targeting Multiple Antigens, Compositions and Methods of Use Thereof
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