JP7114490B2 - キメラ抗体受容体(CARs)の構成およびその使用方法 - Google Patents
キメラ抗体受容体(CARs)の構成およびその使用方法 Download PDFInfo
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- JP7114490B2 JP7114490B2 JP2018567062A JP2018567062A JP7114490B2 JP 7114490 B2 JP7114490 B2 JP 7114490B2 JP 2018567062 A JP2018567062 A JP 2018567062A JP 2018567062 A JP2018567062 A JP 2018567062A JP 7114490 B2 JP7114490 B2 JP 7114490B2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2016/039306 | 2016-06-24 | ||
| PCT/US2016/039306 WO2016210293A1 (en) | 2015-06-25 | 2016-06-24 | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| US201662369004P | 2016-07-29 | 2016-07-29 | |
| US62/369,004 | 2016-07-29 | ||
| PCT/US2016/068349 WO2017222593A1 (en) | 2016-06-24 | 2016-12-22 | Chimeric antigen receptors (cars), compositions and methods thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522973A JP2019522973A (ja) | 2019-08-22 |
| JP2019522973A5 JP2019522973A5 (enExample) | 2020-02-06 |
| JP7114490B2 true JP7114490B2 (ja) | 2022-08-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567062A Active JP7114490B2 (ja) | 2016-06-24 | 2016-12-22 | キメラ抗体受容体(CARs)の構成およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20200283534A1 (enExample) |
| EP (2) | EP3474867A4 (enExample) |
| JP (1) | JP7114490B2 (enExample) |
| CN (1) | CN109562126A (enExample) |
| CA (1) | CA3029197A1 (enExample) |
| WO (1) | WO2017222593A1 (enExample) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015357535B2 (en) | 2014-12-05 | 2020-05-14 | Eureka Therapeutics, Inc. | Antibodies targeting G-protein coupled receptor and methods of use |
| WO2016100232A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| HRP20220890T1 (hr) | 2015-02-06 | 2022-10-14 | National University Of Singapore | Postupci za povećanje učinkovitosti terapijskih imunosnih stanica |
| US20220348633A1 (en) * | 2015-06-25 | 2022-11-03 | Icell Gene Therapeutics Llc | COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHOD OF USE THEREOF |
| TWI833684B (zh) * | 2015-06-25 | 2024-03-01 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體(car)、組合物及其使用方法 |
| US20220241327A1 (en) * | 2015-06-25 | 2022-08-04 | Icell Gene Therapeutics Llc | Chimeric Antigen Receptor (CAR) Targeting Multiple Antigens, Compositions and Methods of Use Thereof |
| EP3368571B1 (en) | 2015-10-30 | 2022-12-07 | The Regents of The University of California | Transforming growth factor-beta-responsive polypeptides and their methods for use |
| WO2017075537A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| MA43134A (fr) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | Compositions et méthodes de transduction tumorale |
| US11384156B2 (en) * | 2016-07-25 | 2022-07-12 | The Nemours Foundation | Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases |
| US12350349B2 (en) | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| CA3039136A1 (en) | 2016-09-02 | 2018-03-08 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| CA3042613A1 (en) * | 2016-11-11 | 2018-05-17 | Autolus Limited | Chimeric antigen receptor |
| WO2018124766A2 (ko) | 2016-12-28 | 2018-07-05 | 주식회사 녹십자랩셀 | 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포 |
| EP3568406A4 (en) * | 2017-01-10 | 2020-10-21 | The General Hospital Corporation | T LYMPHOCYTES EXPRESSING A CHEMERICAL ANTIGENIC RECEPTOR |
| WO2018132427A1 (en) | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
| KR102709603B1 (ko) | 2017-02-28 | 2024-09-27 | 보르 바이오파마 인크. | 계통 특이적 단백질의 억제를 위한 조성물 및 방법 |
| KR20190141695A (ko) | 2017-04-13 | 2019-12-24 | 센티 바이오사이언시스, 인코포레이티드 | 병용 암 면역요법 |
| EP4759318A2 (en) * | 2017-04-14 | 2026-06-17 | The General Hospital Corporation | Chimeric antigen receptor t cells targeting the tumor microenvironment |
| JP2020517259A (ja) * | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| BR112019023608A2 (pt) | 2017-05-12 | 2020-05-26 | Crispr Therapeutics Ag | Materiais e métodos para células manipuladas e seus usos em imuno-oncologia |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| CN118853581A (zh) | 2017-06-21 | 2024-10-29 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)、组合物及其使用方法 |
| US20200306301A1 (en) | 2017-07-03 | 2020-10-01 | Torque Therapeutics, Inc. | Polynucleotides Encoding Immunostimulatory Fusion Molecules and Uses Thereof |
| AU2018309735B2 (en) * | 2017-07-31 | 2025-03-13 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD19/CD20 immunotherapy |
| CA3071282A1 (en) | 2017-08-10 | 2019-02-14 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
| EP3694870A1 (en) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| US11905528B2 (en) * | 2017-10-12 | 2024-02-20 | Icell Gene Therapeutics Inc. | Compound chimeric antigen receptor (cCAR) targeting multiple antigens, compositions and methods of use thereof |
| CA3078963A1 (en) | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | Anti-cd45-based conditioning methods and uses thereof in conjunction with gene-edited cell-based therapies |
| US11066475B2 (en) | 2017-11-01 | 2021-07-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides |
| MA49911A (fr) | 2017-11-01 | 2020-06-24 | Juno Therapeutics Inc | Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| KR102774451B1 (ko) | 2017-11-14 | 2025-02-28 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| KR20190065234A (ko) * | 2017-11-30 | 2019-06-11 | 그리폴스 다이어그노스틱 솔루션즈 인크. | 면역 관문 억제제인 pd-1 및 pd-l1에 대한 항체 치료를 모니터링하기 위한 면역분석 및 조작된 단백질 |
| CA3087476A1 (en) * | 2018-01-10 | 2019-07-18 | The General Hospital Corporation | Immune cells expressing a chimeric antigen receptor |
| CN108314738B (zh) * | 2018-01-29 | 2020-09-08 | 山东兴瑞生物科技有限公司 | 一种共表达细胞因子il-21的双特异性嵌合抗原受体、质粒、cik细胞及mm病应用 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| WO2019160956A1 (en) * | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| CN112041432A (zh) * | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| WO2019178342A1 (en) * | 2018-03-15 | 2019-09-19 | Fundamental Solutions Corporation | Programmable immunocyte receptor complex system |
| US11168138B2 (en) * | 2018-03-26 | 2021-11-09 | Altor Bioscience, Llc | Anti-PDL1, IL-15 and TGF-beta receptor combination molecules |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| EP3773588A4 (en) * | 2018-04-09 | 2022-01-19 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF GRAFT VERSUS HOST DISEASES |
| CN119656304A (zh) * | 2018-04-12 | 2025-03-21 | 凯德药业股份有限公司 | 使用肿瘤微环境的特征的嵌合受体t细胞治疗 |
| EP3561053A1 (en) * | 2018-04-26 | 2019-10-30 | Baylor College of Medicine | Immune effector cells and molecular adaptors with an antigen cytokine complex for effective cancer immunotherapy |
| WO2019210293A1 (en) * | 2018-04-27 | 2019-10-31 | Baylor College Of Medicine | Car t cells with one or more interleukins |
| WO2019210207A2 (en) * | 2018-04-27 | 2019-10-31 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor t regulatory cells for the treatment of atherosclerosis |
| CN110468105B (zh) * | 2018-05-09 | 2024-03-22 | 恺兴生命科技(上海)有限公司 | 表达il-18r结合蛋白的免疫效应细胞 |
| US20200063100A1 (en) | 2018-05-11 | 2020-02-27 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
| CA3103610A1 (en) * | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| CN112368021B (zh) | 2018-06-14 | 2025-02-21 | 2赛文缇生物公司 | Cd79a嵌合抗原受体 |
| WO2019246593A2 (en) * | 2018-06-22 | 2019-12-26 | Fred Hutchinson Cancer Research Center | Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders |
| WO2020009868A1 (en) | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| CN108864307A (zh) * | 2018-07-23 | 2018-11-23 | 北京多赢时代科技有限公司 | 信号肽优化靶向cd19的嵌合抗原受体、表达该嵌合抗原受体的t细胞及制备方法和应用 |
| US20210079111A1 (en) * | 2018-08-04 | 2021-03-18 | AbCyte Therapeutics Inc. | Cd19-cd20 bispecific and dual passway car-t and methods for use thereof |
| CN110862967A (zh) * | 2018-08-27 | 2020-03-06 | 天津天锐生物科技有限公司 | 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| EA202190624A1 (ru) * | 2018-08-31 | 2021-06-09 | Нойл-Иммьюн Байотек, Инк. | Car-экспрессирующие т-клетки и car-экспрессирующий вектор |
| CA3111384A1 (en) * | 2018-09-05 | 2020-03-12 | Poseida Therapeutics, Inc. | Allogeneic cell compositions and methods of use |
| WO2020061048A1 (en) * | 2018-09-17 | 2020-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bicistronic chimeric antigen receptors targeting cd19 and cd20 and their uses |
| WO2020061796A1 (en) * | 2018-09-26 | 2020-04-02 | Hrain Biotechnology Co., Ltd. | Bcma-and-cd19-targeting chimeric antigen receptor and uses thereof |
| CN110950965B (zh) * | 2018-09-26 | 2021-10-15 | 重庆精准生物技术有限公司 | 抗人cd123的嵌合抗原受体及其应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20210338729A1 (en) * | 2018-10-12 | 2021-11-04 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CA3116138A1 (en) * | 2018-10-17 | 2020-04-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US12624086B2 (en) | 2018-10-31 | 2026-05-12 | Mayo Foundation For Medical Education And Research | Materials and methods for treating cancer |
| US12257286B2 (en) | 2018-10-31 | 2025-03-25 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US12264189B2 (en) | 2018-10-31 | 2025-04-01 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP4578507A3 (en) | 2018-11-01 | 2025-11-12 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for t cell engineering |
| CN119569895A (zh) * | 2018-11-01 | 2025-03-07 | 朱诺治疗学股份有限公司 | G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体 |
| US12473345B2 (en) | 2018-11-01 | 2025-11-18 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| WO2020113054A1 (en) | 2018-11-30 | 2020-06-04 | Mustang Bio, Inc. | Methods of treatment using decitabine and a cd123-targeted therapy |
| KR20250116790A (ko) * | 2018-12-12 | 2025-08-01 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 및 car-t 세포 및 사용 방법 |
| WO2020124021A1 (en) * | 2018-12-13 | 2020-06-18 | The General Hospital Corporation | Chimeric antigen receptors targeting cd79b and cd19 |
| IL284294B1 (en) | 2018-12-24 | 2026-06-01 | Haidong Huang | Human 2IG-B7-H3 protein encoding gene, promoter vector, host cell composed thereof, pharmaceutical composition and use thereof |
| EP3908613A4 (en) * | 2019-01-07 | 2022-10-19 | Celluris Participações Ltda. | BISPECIFIC IN-TANDEM RECEPTOR CAR AND METHODS FOR MODULATION OF THE TUMOR MICROAREA |
| EP3917313A4 (en) * | 2019-02-01 | 2023-02-08 | Actinium Pharmaceuticals, Inc. | MOLECULES AND THEIR DERIVATIVES AGAINST CD45 |
| KR20210137085A (ko) * | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| WO2020197319A1 (ko) * | 2019-03-28 | 2020-10-01 | 한국생명공학연구원 | 면역세포의 제조방법 및 그의 용도 |
| CA3136618A1 (en) * | 2019-04-10 | 2020-10-15 | Elevatebio Technologies, Inc. | Flt3-specific chimeric antigen receptors and methods of using the same |
| CN110055281B (zh) * | 2019-04-25 | 2020-09-01 | 山东大学第二医院 | 一种用于制备car-t的慢病毒载体及其构建方法和应用 |
| JP7711945B2 (ja) | 2019-04-30 | 2025-07-23 | センティ バイオサイエンシズ インコーポレイテッド | キメラ受容体及びその使用方法 |
| CA3138633A1 (en) | 2019-04-30 | 2020-11-05 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| CA3136737A1 (en) * | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| EP3747904A1 (en) * | 2019-06-03 | 2020-12-09 | Universität Regensburg | Cd25-specific chimeric antigen receptors and their uses |
| AU2020286471B2 (en) * | 2019-06-07 | 2025-07-31 | The Trustees Of The University Of Pennsylvania | Dual CAR expressing T cells individually linked to CD28 and 4-1BB |
| MX2021015495A (es) * | 2019-06-14 | 2022-04-18 | 2Seventy Bio Inc | Composiciones y métodos para tratar cáncer. |
| WO2020263484A1 (en) * | 2019-06-28 | 2020-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for treating neuromyelitis optica spectrum diseases |
| CN112204135B (zh) * | 2019-07-06 | 2026-03-06 | 苏州克睿基因生物科技有限公司 | 一种表达cd3抗体受体复合物的免疫细胞及其用途 |
| EP3997129B1 (en) * | 2019-07-11 | 2025-11-26 | Valkyr, Inc. | System and methods relating to chimeric autoantibody receptors |
| AU2020315213A1 (en) * | 2019-07-17 | 2022-02-03 | National University Of Singapore | Functional binders synthesized and secreted by immune cells |
| CN110452294B (zh) * | 2019-08-06 | 2020-08-07 | 复旦大学 | 五种铰链区及其嵌合抗原受体和免疫细胞 |
| WO2021041936A1 (en) * | 2019-08-28 | 2021-03-04 | Montefiore Medical Center | Cd25 chimeric antigen receptors and uses thereof |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药(上海)有限公司 | 表达il-15的免疫效应细胞 |
| WO2021064718A1 (en) * | 2019-10-01 | 2021-04-08 | Case Western Reserve University | Targeting b cell activating factor receptor (baff-r) using ligand-based chimeric antigen receptor (car)-t cells |
| CA3153441A1 (en) * | 2019-10-01 | 2021-04-08 | Reshmi Parameswaran | Targeting b cell activating factor receptor (baff-r) using ligand-based chimeric antigen receptor (car)-t cells |
| AU2020361683A1 (en) * | 2019-10-11 | 2022-05-19 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting CD13 and TIM-3 with CAR T cells to treat acute myeloid leukemia |
| TWI717880B (zh) * | 2019-10-24 | 2021-02-01 | 中國醫藥大學附設醫院 | Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物 |
| AU2020382219A1 (en) | 2019-11-13 | 2022-05-12 | Crispr Therapeutics Ag | Manufacturing process for making T cells expressing chimeric antigen receptors |
| CN110760007B (zh) * | 2019-11-21 | 2022-08-26 | 博生吉医药科技(苏州)有限公司 | Cd7-car-t细胞及其制备和应用 |
| US20230272035A1 (en) * | 2019-12-05 | 2023-08-31 | Vycellix, Inc. | Modulators of the immune escape mechanism for universal cell therapy |
| WO2021113780A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| IL295878A (en) * | 2020-02-27 | 2022-10-01 | Novartis Ag | Methods for producing cells expressing a chimeric antigen receptor |
| US20230174653A1 (en) * | 2020-04-06 | 2023-06-08 | St. Jude Children's Research Hospital, Inc. | B7-h3 chimeric antigen receptors |
| CN111411085A (zh) * | 2020-04-10 | 2020-07-14 | 格源致善(上海)生物科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
| CN113527507A (zh) * | 2020-04-16 | 2021-10-22 | 上海赛比曼生物科技有限公司 | 靶向cd22的嵌合抗原受体及其制法和应用 |
| CN115777017A (zh) * | 2020-05-06 | 2023-03-10 | 亘喜生物科技(上海)有限公司 | 用于t细胞工程改造的组合物及方法 |
| US12202882B2 (en) | 2020-05-08 | 2025-01-21 | Alpine Immune Sciences, Inc. | APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof |
| WO2022040577A1 (en) * | 2020-08-20 | 2022-02-24 | City Of Hope | Compositions and uses of cd45 targeted chimeric antigen receptor modified t cells |
| AU2021334950A1 (en) * | 2020-08-24 | 2023-03-02 | Charité - Universitätsmedizin Berlin | Chimeric antigen receptor (CAR)-expressing cells recognizing CEA |
| CN116568812A (zh) * | 2020-09-08 | 2023-08-08 | 亘喜生物科技(上海)有限公司 | 用于t细胞工程化的组合物和方法 |
| WO2022061837A1 (en) * | 2020-09-27 | 2022-03-31 | Jiangsu Cell Tech Medical Research Institute Co., Ltd. | Fibronectin extra domain b (edb) -specific car-t for cancer |
| CN116783283A (zh) * | 2020-11-13 | 2023-09-19 | Gpb科学有限公司 | 产生具有增加的核酸摄取的细胞群体的方法 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN116981685A (zh) * | 2020-12-03 | 2023-10-31 | 世纪治疗股份有限公司 | 基因工程化细胞及其用途 |
| IL303269A (en) | 2020-12-03 | 2023-07-01 | Century Therapeutics Inc | Genetically engineered cells and uses thereof |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| CN115786271B (zh) * | 2021-01-12 | 2025-07-22 | 上海雅科生物科技有限公司 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
| CN112778427B (zh) * | 2021-01-29 | 2022-03-15 | 武汉思安医疗技术有限公司 | 双特异性cs1-bcma car-t细胞及其应用 |
| US20220267423A1 (en) * | 2021-02-22 | 2022-08-25 | IgGenix, Inc. | Ige antibodies cross-reactive to allergens and tumor antigens |
| CN112698037B (zh) * | 2021-03-25 | 2021-06-25 | 北京积水潭医院 | 一种检测多发性骨髓瘤治疗效果的抗体组合物及其试剂盒和应用 |
| WO2022234976A1 (ko) * | 2021-05-04 | 2022-11-10 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| KR102671411B1 (ko) * | 2021-05-11 | 2024-06-04 | 진화섭 | Baff 세포외 도메인을 포함하는 키메릭 항원 수용체 및 이의 용도 |
| CN115340610A (zh) * | 2021-05-12 | 2022-11-15 | 珠海市丽珠单抗生物技术有限公司 | 双特异性car t细胞及其应用 |
| CN113402619B (zh) * | 2021-06-30 | 2022-03-22 | 徐州医科大学 | 一种靶向B7H3共表达IL-21的全人源嵌合抗原受体、iNKT细胞及其用途 |
| CN113549158B (zh) * | 2021-07-19 | 2022-10-21 | 广州百暨基因科技有限公司 | 包含突变型il15以及嵌合抗原受体的融合蛋白 |
| US20230060292A1 (en) * | 2021-07-26 | 2023-03-02 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
| JP2024531910A (ja) * | 2021-08-04 | 2024-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト | Lat活性化キメラ抗原受容体t細胞及びその使用方法 |
| US20250222102A1 (en) * | 2021-08-24 | 2025-07-10 | City Of Hope | Nk cells expressing il-15 and checkpoint inhibitors for the treatment of cancer |
| KR20230032557A (ko) | 2021-08-31 | 2023-03-07 | 주식회사 이뮤노로지컬디자이닝랩 | Baff 세포외 도메인을 포함하는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
| AU2022347132A1 (en) * | 2021-09-16 | 2024-05-02 | Gt Biopharma, Inc. | B7-h3 targeting fusion proteins and methods of use thereof |
| EP4433512A4 (en) * | 2021-11-19 | 2025-12-31 | Univ Pennsylvania | Genetically modified pan-leukocyte-specific CD45 antigen to facilitate T-lymphocyte therapy |
| US20230210900A1 (en) * | 2022-01-04 | 2023-07-06 | Kyverna Therapeutics, Inc. | Methods for treating autoimmune diseases |
| CN116606378A (zh) * | 2022-02-08 | 2023-08-18 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 靶向cd52的嵌合抗原受体及其应用 |
| EP4272754A1 (en) | 2022-05-04 | 2023-11-08 | Universitätsklinikum Hamburg-Eppendorf | Method for producing cells expressing a chimeric antigen receptor (car) |
| US20250295773A1 (en) * | 2022-05-10 | 2025-09-25 | Miltenyi Biotec B.V. & Co. KG | Compositions comprising il-15, il-15 receptor alpha and the intracellular signaling domain of cd2 for immune cell therapy |
| WO2024026455A2 (en) * | 2022-07-29 | 2024-02-01 | Shoreline Biosciences, Inc. | Methods and compositions for generating chimeric antigen receptor-monocytes/macrophages |
| EP4487868A1 (en) | 2023-07-06 | 2025-01-08 | Universitätsklinikum Hamburg-Eppendorf | Modified nk cell expressing a chimeric antigen receptor |
| CN121969385A (zh) | 2023-09-11 | 2026-05-01 | 丹娜-法伯癌症研究院 | 含有il-2变体以增强car t细胞的功能性的car-衔接子 |
| WO2025072372A1 (en) * | 2023-09-26 | 2025-04-03 | The General Hospital Corporation | Car-t cells expressing vegf binding proteins |
| CN117050195B (zh) * | 2023-10-13 | 2023-12-19 | 旭和(天津)医药科技有限公司 | 一种靶向baffr嵌合抗原受体、car-t细胞和应用 |
| WO2025264723A1 (en) * | 2024-06-18 | 2025-12-26 | The University Of Chicago | Co-expressed chimeric antigen receptors for cancer treatment |
| WO2026082736A1 (en) * | 2024-10-14 | 2026-04-23 | Cimeio Therapeutics Ag | Chimeric antigen receptor (car) that targets receptor-type tyrosine phosphatase c (cd45) and its use to related applications |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030147865A1 (en) | 2002-02-07 | 2003-08-07 | Benoit Salomon | Cell therapy using immunoregulatory T-cells |
| JP2015513394A (ja) | 2012-02-13 | 2015-05-14 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネ | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2015120180A1 (en) | 2014-02-05 | 2015-08-13 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants |
| US20150307623A1 (en) | 2012-12-20 | 2015-10-29 | Anthrogenesis Corporation | Chimeric antigen receptors |
| WO2015168613A2 (en) | 2014-05-02 | 2015-11-05 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
| WO2016044605A1 (en) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2016073755A2 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| JP2018518974A (ja) | 2015-06-25 | 2018-07-19 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の構成およびその使用方法 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6764681B2 (en) | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
| EP1235842A4 (en) | 1999-10-15 | 2003-04-23 | Univ Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US20080254027A1 (en) | 2002-03-01 | 2008-10-16 | Bernett Matthew J | Optimized CD5 antibodies and methods of using the same |
| JP4596916B2 (ja) | 2002-09-05 | 2010-12-15 | メディミューン,エルエルシー | Cd2拮抗薬を投与することによりt細胞悪性腫瘍を予防または治療する方法 |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20080299042A1 (en) | 2004-04-30 | 2008-12-04 | Biogen Idec Ma Inc. | Membrane Associated Molecules |
| US20050277587A1 (en) | 2004-06-10 | 2005-12-15 | Academia Sinica | CD7 as biomarker and therapeutic target for psoriasis |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| WO2007120368A2 (en) * | 2006-01-09 | 2007-10-25 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| ES2437315T3 (es) | 2006-06-12 | 2014-01-10 | Janssen Biotech, Inc. | Método para la detección de actividad IL-16 y modulación de actividad IL-16 en base a niveles RANTES proxy |
| WO2008140477A2 (en) | 2006-11-02 | 2008-11-20 | Capon Daniel J | Hybrid immunoglobulins with moving parts |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| CA2735456C (en) * | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| CA2739608A1 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| EP2389443B1 (en) | 2009-01-23 | 2018-11-14 | Roger Williams Hospital | Retroviral vectors encoding multiple highly homologous non-viral polypeptides and the use of same |
| BRPI1013927A2 (pt) | 2009-05-13 | 2016-04-05 | Genzyme Corp | métodos e composições para o tratamento de lúpus |
| WO2010132697A2 (en) | 2009-05-13 | 2010-11-18 | Genzyme Corporation | Methods and compositions for treatment |
| EP2325322A1 (en) | 2009-11-23 | 2011-05-25 | 4-Antibody AG | Retroviral vector particles and methods for their generation and use |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP5897035B2 (ja) | 2010-12-14 | 2016-03-30 | ユニバーシティ オブ メリーランド,ボルチモア | 汎用の抗タグキメラ抗原受容体発現t細胞及びがんを治療する方法 |
| WO2012154344A1 (en) | 2011-04-06 | 2012-11-15 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| KR101870555B1 (ko) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| KR102366029B1 (ko) * | 2011-09-30 | 2022-02-23 | 추가이 세이야쿠 가부시키가이샤 | 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자 |
| CA3285826A1 (en) | 2012-02-22 | 2026-03-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| TWI619729B (zh) | 2012-04-02 | 2018-04-01 | 再生元醫藥公司 | 抗-hla-b*27抗體及其用途 |
| RU2729401C2 (ru) | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| SG11201507026WA (en) * | 2013-02-06 | 2015-10-29 | Anthrogenesis Corp | Modified t lymphocytes having improved specificity |
| IL305629A (en) | 2013-02-15 | 2023-11-01 | Univ California | Chimeric antigen receptor and methods of using it |
| ES2769574T3 (es) * | 2013-03-15 | 2020-06-26 | Michael C Milone | Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva |
| SI2997141T1 (sl) * | 2013-05-13 | 2023-04-28 | Cellectis | CD19 specifični himerni antigenski receptor in njegova uporaba |
| EP2997134B1 (en) * | 2013-05-14 | 2020-06-24 | Board of Regents, The University of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| JP6136650B2 (ja) * | 2013-06-28 | 2017-05-31 | ブラザー工業株式会社 | カートリッジ |
| CA2920539C (en) * | 2013-08-08 | 2024-01-02 | Cytune Pharma | Combined pharmaceutical composition |
| US20160250258A1 (en) | 2013-10-31 | 2016-09-01 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| AP2016009222A0 (en) | 2013-11-04 | 2016-05-31 | Glenmark Pharmaceuticals Sa | Production of t cell retargeting hetero-dimeric immunoglobulins |
| EP3858379A1 (en) | 2013-11-21 | 2021-08-04 | Autolus Limited | Cell |
| EP3097117B1 (en) | 2014-01-21 | 2023-10-04 | Novartis Ag | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| DK3105317T3 (en) | 2014-02-14 | 2019-01-14 | Cellectis | Immunotherapy cells that are genetically engineered to target antigen on both immune cells and pathological cells |
| JP6665102B2 (ja) * | 2014-02-21 | 2020-03-13 | セレクティスCellectis | 制御性t細胞をインサイチューで阻害するための方法 |
| SG10201808811QA (en) * | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Method and compositions for cellular immunotherapy |
| JP6682509B2 (ja) | 2014-05-14 | 2020-04-15 | カースゲン セラピューティクス リミテッドCarsgen Therapeutics Limited | キメラ抗原受容体タンパク質をコードする核酸およびキメラ抗原受容体タンパク質を発現するtリンパ球 |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| EP3712171A1 (en) * | 2014-08-19 | 2020-09-23 | Novartis AG | Treatment of cancer using a cd123 chimeric antigen receptor |
| DK3186284T3 (da) | 2014-08-28 | 2022-05-09 | Bioatla Inc | Betinget aktive kimæriske antigenreceptorer til modificerede t-celler |
| HRP20240357T1 (hr) * | 2014-12-24 | 2024-06-07 | Autolus Limited | Stanica |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| GB201518817D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Cell |
| JP6976960B2 (ja) * | 2015-11-27 | 2021-12-08 | カーサリクス プロプライエタリー リミテッド | 遺伝子改変された細胞およびその使用 |
| SG11201807489PA (en) * | 2016-03-04 | 2018-09-27 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| GB201610512D0 (en) * | 2016-06-16 | 2016-08-03 | Autolus Ltd | Chimeric antigen receptor |
| JP7467117B2 (ja) * | 2016-10-07 | 2024-04-15 | ノバルティス アーゲー | 癌の治療のためのキメラ抗原受容体 |
-
2016
- 2016-12-22 CN CN201680087034.6A patent/CN109562126A/zh active Pending
- 2016-12-22 JP JP2018567062A patent/JP7114490B2/ja active Active
- 2016-12-22 CA CA3029197A patent/CA3029197A1/en active Pending
- 2016-12-22 US US16/312,769 patent/US20200283534A1/en not_active Abandoned
- 2016-12-22 EP EP16906492.0A patent/EP3474867A4/en not_active Withdrawn
- 2016-12-22 EP EP23220747.2A patent/EP4353750A3/en not_active Withdrawn
- 2016-12-22 WO PCT/US2016/068349 patent/WO2017222593A1/en not_active Ceased
-
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- 2017-06-21 US US15/538,620 patent/US11820819B2/en active Active
-
2022
- 2022-08-01 US US17/878,339 patent/US20230340113A1/en not_active Abandoned
-
2023
- 2023-10-13 US US18/379,708 patent/US20240141041A1/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030147865A1 (en) | 2002-02-07 | 2003-08-07 | Benoit Salomon | Cell therapy using immunoregulatory T-cells |
| JP2015513394A (ja) | 2012-02-13 | 2015-05-14 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネ | 二重特異性キメラ抗原受容体およびその治療的使用 |
| US20150307623A1 (en) | 2012-12-20 | 2015-10-29 | Anthrogenesis Corporation | Chimeric antigen receptors |
| WO2015120180A1 (en) | 2014-02-05 | 2015-08-13 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants |
| WO2015168613A2 (en) | 2014-05-02 | 2015-11-05 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
| WO2016044605A1 (en) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2016073755A2 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| JP2018518974A (ja) | 2015-06-25 | 2018-07-19 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の構成およびその使用方法 |
| JP6961497B2 (ja) | 2015-06-25 | 2021-11-05 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の構成およびその使用方法 |
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| EP3474867A4 (en) | 2020-05-20 |
| US20200024342A9 (en) | 2020-01-23 |
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| US20200283534A1 (en) | 2020-09-10 |
| JP2019522973A (ja) | 2019-08-22 |
| EP3474867A1 (en) | 2019-05-01 |
| CA3029197A1 (en) | 2017-12-28 |
| EP4353750A3 (en) | 2024-07-24 |
| US20240141041A1 (en) | 2024-05-02 |
| CN109562126A (zh) | 2019-04-02 |
| EP4353750A2 (en) | 2024-04-17 |
| US20230340113A1 (en) | 2023-10-26 |
| WO2017222593A1 (en) | 2017-12-28 |
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