JP2017522346A5 - - Google Patents

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JP2017522346A5
JP2017522346A5 JP2017505176A JP2017505176A JP2017522346A5 JP 2017522346 A5 JP2017522346 A5 JP 2017522346A5 JP 2017505176 A JP2017505176 A JP 2017505176A JP 2017505176 A JP2017505176 A JP 2017505176A JP 2017522346 A5 JP2017522346 A5 JP 2017522346A5
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Japan
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methyl
hydroxy
quinolyl
unsubstituted
substituted
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JP2017505176A
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Japanese (ja)
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JP2017522346A (ja
JP6759514B2 (ja
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Priority claimed from PCT/EP2015/067400 external-priority patent/WO2016016316A1/en
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Publication of JP2017522346A5 publication Critical patent/JP2017522346A5/ja
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JP2017505176A 2014-08-01 2015-07-29 ブロモドメインに対して活性な化合物 Active JP6759514B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1450919-4 2014-08-01
SE1450919 2014-08-01
PCT/EP2015/067400 WO2016016316A1 (en) 2014-08-01 2015-07-29 Compounds active towards bromodomains

Publications (3)

Publication Number Publication Date
JP2017522346A JP2017522346A (ja) 2017-08-10
JP2017522346A5 true JP2017522346A5 (OSRAM) 2019-09-26
JP6759514B2 JP6759514B2 (ja) 2020-09-23

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JP2017505176A Active JP6759514B2 (ja) 2014-08-01 2015-07-29 ブロモドメインに対して活性な化合物

Country Status (19)

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US (1) US10752640B2 (OSRAM)
EP (1) EP3174868B1 (OSRAM)
JP (1) JP6759514B2 (OSRAM)
KR (2) KR102633122B1 (OSRAM)
CN (1) CN106573915B (OSRAM)
AU (1) AU2015295405B2 (OSRAM)
CA (1) CA2956871C (OSRAM)
CL (1) CL2017000240A1 (OSRAM)
CO (1) CO2017001994A2 (OSRAM)
DK (1) DK3174868T3 (OSRAM)
ES (1) ES2896400T3 (OSRAM)
IL (1) IL250320B (OSRAM)
MA (1) MA40551A (OSRAM)
MX (1) MX378273B (OSRAM)
MY (1) MY187540A (OSRAM)
RU (1) RU2743074C2 (OSRAM)
SG (2) SG11201700776XA (OSRAM)
WO (1) WO2016016316A1 (OSRAM)
ZA (1) ZA201700670B (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990403A1 (en) * 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
KR20180026774A (ko) 2015-07-17 2018-03-13 후지필름 가부시키가이샤 질소-함유 헤테로시클릭 화합물
CN109153647A (zh) * 2016-02-15 2019-01-04 分子医学研究中心责任有限公司 用于治疗癌症的taf1抑制剂
AU2017245641A1 (en) * 2016-04-07 2018-09-13 Glaxosmithkline Intellectual Property (No.2) Limited Pyridyl derivatives as bromodomain inhibitors
TW202413340A (zh) 2016-07-12 2024-04-01 美商銳新醫藥公司 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪
US20190247302A1 (en) * 2016-10-21 2019-08-15 University Of Miami Materials and methods for treating ophthalmic inflammation
AU2017385292B2 (en) * 2016-12-27 2020-05-14 Fujifilm Corporation Antitumor agent and bromodomain inhibitor
SG11201906209SA (en) 2017-01-23 2019-08-27 Revolution Medicines Inc Bicyclic compounds as allosteric shp2 inhibitors
RU2019126455A (ru) 2017-01-23 2021-02-24 Революшн Медсинз, Инк. Пиридиновые соединения в качестве аллостерических ингибиторов shp2
JP2020506203A (ja) * 2017-02-07 2020-02-27 ヤンセン ファーマシューティカ エヌ.ベー. 肝線維症の治療のための医薬品としてのスルファモイルアリール誘導体およびその使用
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
JP2020536881A (ja) * 2017-10-12 2020-12-17 レヴォリューション・メディスンズ,インコーポレイテッド アロステリックshp2阻害剤としてのピリジン、ピラジンおよびトリアジン化合物
RU2020123241A (ru) 2017-12-15 2022-01-17 Революшн Медсинз, Инк. Полициклические соединения в качестве аллостерических ингибиторов shp2
EP3750885A4 (en) * 2018-02-06 2021-10-27 Shanghai Haihe Pharmaceutical Co., Ltd. COMPOUND PRESENTING AN INHIBITORING ACTIVITY OF BET, ITS PREPARATION PROCESS AND ITS USE
CN110386927B (zh) * 2018-04-20 2022-09-23 中国科学院上海药物研究所 组蛋白乙酰转移酶(hat)抑制剂及其用途
CN109053542A (zh) * 2018-07-25 2018-12-21 南通大学 一种6-溴-5-羟基异吲哚啉-1-酮的化学合成方法
CA3107120A1 (en) 2018-07-31 2020-02-06 The Trustees Of Princeton University Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
AU2019372057A1 (en) * 2018-11-02 2021-05-27 Merck Sharp & Dohme Llc 2-amino-N-heteroaryl-nicotinamides as NAV1.8 inhibitors
JP7676308B2 (ja) 2018-12-20 2025-05-14 アムジエン・インコーポレーテツド Kif18a阻害剤として有用なヘテロアリールアミド
MA54546A (fr) 2018-12-20 2022-03-30 Amgen Inc Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
WO2020132651A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Kif18a inhibitors
WO2020144375A1 (en) 2019-01-11 2020-07-16 Grünenthal GmbH Substituted pyrrolidine amides iii
AU2020324406A1 (en) 2019-08-02 2022-03-17 Amgen Inc. KIF18A inhibitors
JP7756070B2 (ja) * 2019-08-02 2025-10-17 アムジエン・インコーポレーテツド Kif18a阻害剤としてのピリジン誘導体
CN114286820A (zh) * 2019-08-21 2022-04-05 卡尔维斯塔制药有限公司 酶抑制剂
JP2023511472A (ja) * 2019-10-29 2023-03-20 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト がんの治療のための二官能性化合物
GB201918587D0 (en) * 2019-12-17 2020-01-29 Artios Pharma Ltd Novel compounds
IL294705A (en) * 2020-01-24 2022-09-01 Univ Princeton Heterocyclic compounds and uses thereof
WO2022103899A1 (en) * 2020-11-10 2022-05-19 Foghorn Therapeutics Inc. Compounds and uses thereof
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use
US20250092014A1 (en) * 2021-01-19 2025-03-20 Metrea Biosciences, Inc. Compounds and methods of activating lipoprotein lipase
US20240216362A1 (en) * 2021-04-19 2024-07-04 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease
CA3213692A1 (en) * 2021-04-22 2022-10-27 Mark Esposito Heterocyclic compounds and uses thereof
WO2023274418A1 (zh) * 2021-07-02 2023-01-05 南京明德新药研发有限公司 蛋白降解靶向嵌合体类化合物
MX2024001155A (es) * 2021-07-30 2024-07-01 Confo Therapeutics N V Compuestos para el tratamiento del dolor, en particular el dolor neuropatico, y/u otras enfermedades o trastornos que se asocian con at2r y/o se?alizacion mediada por at2r.
CA3255932A1 (en) 2022-04-19 2023-10-26 Nuevolution As ACTIVE COMPOUNDS AGAINST BROMODOMAINS
WO2023205475A1 (en) * 2022-04-21 2023-10-26 Nimbus Clotho, Inc. Ctps1 inhibitors and uses thereof
IL316531A (en) 2022-05-11 2024-12-01 Foghorn Therapeutics Inc Compounds and their uses
EP4539934A1 (en) * 2022-06-24 2025-04-23 Zydus Lifesciences Limited Treatment for glomerular diseases
CN119768400A (zh) * 2022-11-11 2025-04-04 苏州信诺维医药科技股份有限公司 一种稠环化合物、其用途及含其的药物组合物

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5328935B2 (OSRAM) 1972-01-20 1978-08-17
JPS56104333A (en) * 1980-01-23 1981-08-20 Fuji Photo Film Co Ltd Color photographic sensitive material
DE3445669A1 (de) 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS6232459A (ja) 1985-08-05 1987-02-12 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS6238463A (ja) 1985-08-14 1987-02-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−感光材料の画像形成方法
JPH067250B2 (ja) 1985-10-18 1994-01-26 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料
JPS6292939A (ja) 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd 熱現像感光材料
JPH0756566B2 (ja) 1985-11-06 1995-06-14 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料の処理方法
JPS62129853A (ja) 1985-11-30 1987-06-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
JPS62153953A (ja) 1985-12-27 1987-07-08 Fuji Photo Film Co Ltd カラ−写真感光材料
JPS62173466A (ja) 1986-01-28 1987-07-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS62222251A (ja) 1986-02-17 1987-09-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62257158A (ja) 1986-04-30 1987-11-09 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
EP0254280B1 (en) 1986-07-22 1993-12-29 Fuji Photo Film Co., Ltd. Method for processing silver halide color photographic material
DE3803775A1 (de) 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH02234158A (ja) 1989-03-07 1990-09-17 Fuji Photo Film Co Ltd カラー感光材料
JPH02264946A (ja) 1989-04-05 1990-10-29 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JPH02267548A (ja) 1989-04-10 1990-11-01 Fuji Photo Film Co Ltd 画像形成法
DE3925584A1 (de) 1989-08-02 1991-02-07 Boehringer Mannheim Gmbh Neue n-(dimethyloxophosphinylmethyl-)-lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4027592A1 (de) 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JPH04315148A (ja) 1991-04-15 1992-11-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
GB9205702D0 (en) 1992-03-16 1992-04-29 Fujisawa Pharmaceutical Co A new use of a quinazoline derivative
DE69310098T2 (de) 1992-10-15 1997-07-31 Fuji Photo Film Co., Ltd., Minami-Ashigara, Kanagawa Verarbeitungsverfahren für farbphotographisches Silberhalogenidmaterial
ES2186720T3 (es) 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.
US5756502A (en) 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
TW381092B (en) * 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
US5747235A (en) 1996-01-26 1998-05-05 Eastman Kodak Company Silver halide light sensitive emulsion layer having enhanced photographic sensitivity
JP2000505471A (ja) 1996-02-28 2000-05-09 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5780480A (en) 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
JP2002511054A (ja) 1996-12-30 2002-04-09 メルク エンド カンパニー インコーポレーテッド ファルネシル蛋白トランスフェラーゼ阻害薬
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
WO1999031086A1 (en) 1997-12-12 1999-06-24 Smithkline Beecham Plc Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists
HU227711B1 (en) 1997-12-22 2011-12-28 Bayer Healthcare Llc Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas and pharmaceutical compositions containing them
DE19839499A1 (de) 1998-08-29 2000-03-02 Merck Patent Gmbh 2-Oxo-2H-chinolinderivate
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
JP2002341484A (ja) 2001-03-12 2002-11-27 Fuji Photo Film Co Ltd 熱現像感光材料
JP2002296731A (ja) 2001-03-30 2002-10-09 Fuji Photo Film Co Ltd 熱現像カラー画像記録材料
JP2004532856A (ja) * 2001-04-30 2004-10-28 藤沢薬品工業株式会社 アポリポタンパク質b阻害剤としてのビアリールカルボキサミド化合物
BR0209687A (pt) 2001-05-15 2004-09-14 Du Pont Método de controle de doenças vegetais, composto e composição
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Grk阻害剤
EP1388342A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
BR0313743A (pt) 2002-08-23 2005-07-05 Chiron Corp Benzimidazol quinolinonas e usos destas
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
AU2003272347A1 (en) 2002-09-17 2004-04-08 Merck And Co., Inc. Removal of aldehyde impurity by reactive polystyrene resin
EP1572212A2 (en) 2002-12-11 2005-09-14 7TM Pharma A/S Quinoline compounds for use in mch receptor related disorders
US20040142950A1 (en) 2003-01-17 2004-07-22 Bunker Amy Mae Amide and ester matrix metalloproteinase inhibitors
US7205318B2 (en) 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
WO2004110350A2 (en) 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2004113330A1 (en) 2003-05-19 2004-12-29 Irm Llc Immunosuppressant compounds and compositions
KR101167573B1 (ko) 2003-11-07 2012-07-30 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 개선된 약학적 성질을 갖는 퀴놀리논 화합물의 약학적으로허용가능한 염
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
JP2008501689A (ja) 2004-06-03 2008-01-24 ブランデイス ユニヴァーシティー シンコナアルカロイドを基本構造とする二官能触媒を用いた不斉マイケル付加およびアルドール付加反応
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
EP1655295A1 (en) * 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
US20060281763A1 (en) 2005-03-25 2006-12-14 Axon Jonathan R Carboxamide inhibitors of TGFbeta
GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
GB0509224D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
WO2006130437A2 (en) 2005-05-27 2006-12-07 Brandeis University Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids
US20090240055A1 (en) 2005-09-23 2009-09-24 Krepski Larry R Method for 1H-Imidazo[4,5-C] Pyridines and Analogs Thereof
BRPI0709555B1 (pt) 2006-02-16 2015-11-03 Syngenta Ltd compostos pesticidas contendo uma estrutura de bisamida bicíclica, composição pesticida, e método para controlar pestes.
GB0605689D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic compounds
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
JP2009537632A (ja) 2006-05-19 2009-10-29 バイエル・ヘルスケア・アクチェンゲゼルシャフト 過剰増殖性障害および血管新生障害の処置に有用なピリドンカルボキサミド誘導体
WO2008029152A2 (en) 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
CA2665438C (en) 2006-10-04 2014-12-02 Tibotec Pharmaceuticals Ltd. Carboxamide 4-[(4-pyridyl)amino]pyrimidines useful as hcv inhibitors
US20080186971A1 (en) 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
AU2008219166B2 (en) 2007-02-16 2013-05-16 Amgen Inc. Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors
CA2680177A1 (en) * 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
JP2008280341A (ja) 2007-04-12 2008-11-20 Sumitomo Chemical Co Ltd ヒドラジド化合物およびその防除用途
EP2147310A4 (en) 2007-04-27 2010-09-08 Univ Rochester COMPOSITIONS AND METHODS OF INHIBITING G-PROTEIN SIGNALING
EP2008658A1 (en) 2007-06-28 2008-12-31 Bayer Schering Pharma Aktiengesellschaft Synergistic combination of anthranilamide pyridinureas and benzamide derivatives
RU2543620C2 (ru) 2007-09-17 2015-03-10 Эббви Бахамаз Лтд. Производные урацила или тимина для лечения гепатита с
EA201001847A1 (ru) 2008-06-11 2011-08-30 Айрм Ллк Соединения и композиции, применяемые для лечения малярии
US20100068204A1 (en) 2008-09-12 2010-03-18 Wyeth 4-aryloxyquinolin-2(1h)-ones as mtor kinase and pi3 kinase inhibitors, for use as anti-cancer agents
US20100267752A1 (en) 2008-10-15 2010-10-21 Gilead Palo Alto, Inc. 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
AU2009331659B2 (en) 2008-12-23 2015-09-03 F. Hoffmann-La Roche Ag Dihydropyridone amides as P2X7 modulators
WO2010101949A1 (en) 2009-03-02 2010-09-10 Sirtris Pharmaceuticals, Inc. 8-substituted quinolines and related analogs as sirtuin modulators
US8278302B2 (en) * 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
ES2652304T3 (es) * 2009-11-05 2018-02-01 Glaxosmithkline Llc Compuesto de benzodiacepina novedoso
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
ES2715611T3 (es) 2010-05-17 2019-06-05 Incozen Therapeutics Pvt Ltd Compuestos novedosos de 3H-imidazo[4,5-b]piridina-3,5-disustituida y 3H-[1,2,3]triazolo[4,5-b]piridina 3,5-disustituida como moduladores de proteína cinasas
WO2011156632A2 (en) 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
WO2012020820A1 (ja) 2010-08-11 2012-02-16 大正製薬株式会社 ヘテロアリール-ピラゾール誘導体
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
PH12013501489A1 (en) 2010-12-17 2013-08-28 Hoffmann La Roche Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
TW201309639A (zh) 2011-02-17 2013-03-01 Lg Life Sciences Ltd 作為gpr119促效劑之肟衍生物
WO2012125668A1 (en) 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
GB201106750D0 (en) * 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106743D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
JP5742439B2 (ja) 2011-05-02 2015-07-01 信越化学工業株式会社 蛍光性化合物及び蛍光性樹脂組成物
DK2713722T3 (en) 2011-05-31 2017-07-03 Celgene Int Ii Sarl Newly known GLP-1 receptor stabilizers and modulators
CN102887895B (zh) 2011-07-22 2016-08-24 山东轩竹医药科技有限公司 吡啶并嘧啶类mTOR抑制剂
US20140315881A1 (en) 2011-07-29 2014-10-23 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013027168A1 (en) * 2011-08-22 2013-02-28 Pfizer Inc. Novel heterocyclic compounds as bromodomain inhibitors
EP2899183B1 (en) * 2011-10-14 2018-09-19 Bristol-Myers Squibb Company Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors
WO2013063462A2 (en) 2011-10-26 2013-05-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of treating hcv infection with a small molecule chk2 inhibitor
US9701658B2 (en) 2012-04-25 2017-07-11 Raqualia Pharma Inc. Amide derivatives as TTX-S blockers
WO2014034719A1 (ja) 2012-08-29 2014-03-06 興和株式会社 Tlr阻害作用を有するキノリン誘導体
WO2014095775A1 (de) 2012-12-20 2014-06-26 Bayer Pharma Aktiengesellschaft Bet-proteininhibitorische dihydrochinoxalinone
JP2016504990A (ja) 2012-12-20 2016-02-18 バイエル ファーマ アクチエンゲゼルシャフト Betタンパク質抑制性ジヒドロピリドピラジノン

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