JP2017081918A5 - - Google Patents

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JP2017081918A5
JP2017081918A5 JP2016214165A JP2016214165A JP2017081918A5 JP 2017081918 A5 JP2017081918 A5 JP 2017081918A5 JP 2016214165 A JP2016214165 A JP 2016214165A JP 2016214165 A JP2016214165 A JP 2016214165A JP 2017081918 A5 JP2017081918 A5 JP 2017081918A5
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chloro
phenyl
disease
pyrimidine
carboxylic acid
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JP2016214165A
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JP6330011B2 (ja
JP2017081918A (ja
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JP2016214165A 2011-08-30 2016-11-01 キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 Active JP6330011B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161528998P 2011-08-30 2011-08-30
US61/528,998 2011-08-30

Related Parent Applications (1)

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JP2014528519A Division JP6038151B2 (ja) 2011-08-30 2012-08-28 キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法

Publications (3)

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JP2017081918A JP2017081918A (ja) 2017-05-18
JP2017081918A5 true JP2017081918A5 (enExample) 2017-06-29
JP6330011B2 JP6330011B2 (ja) 2018-05-23

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JP2014528519A Active JP6038151B2 (ja) 2011-08-30 2012-08-28 キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法
JP2016214165A Active JP6330011B2 (ja) 2011-08-30 2016-11-01 キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法

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JP2014528519A Active JP6038151B2 (ja) 2011-08-30 2012-08-28 キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法

Country Status (28)

Country Link
US (1) US9981918B2 (enExample)
EP (2) EP2750677B1 (enExample)
JP (2) JP6038151B2 (enExample)
KR (2) KR102027287B1 (enExample)
CN (1) CN106518845B (enExample)
AR (1) AR087710A1 (enExample)
AU (2) AU2012302144B2 (enExample)
BR (1) BR112014004741B1 (enExample)
CA (1) CA2844128C (enExample)
CL (1) CL2014000447A1 (enExample)
CO (1) CO7020907A2 (enExample)
DK (1) DK2750677T3 (enExample)
EA (2) EA032526B1 (enExample)
ES (2) ES2765805T3 (enExample)
HR (1) HRP20170928T1 (enExample)
HU (1) HUE034802T2 (enExample)
IL (2) IL231270A (enExample)
MX (2) MX364378B (enExample)
MY (1) MY166890A (enExample)
PE (1) PE20142081A1 (enExample)
PH (2) PH12017502049A1 (enExample)
PL (1) PL2750677T3 (enExample)
PT (1) PT2750677T (enExample)
SG (1) SG2014012926A (enExample)
SI (1) SI2750677T1 (enExample)
TW (2) TWI592400B (enExample)
WO (1) WO2013033085A1 (enExample)
ZA (1) ZA201401097B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110092266A (ko) 2008-08-04 2011-08-17 씨에이치디아이 파운데이션, 인코포레이티드 소정 키누레닌-3-모노옥시게나아제 억제제, 약학적 조성물, 및 그의 사용 방법
MY166890A (en) * 2011-08-30 2018-07-24 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2972419T3 (es) 2012-04-05 2024-06-12 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas y métodos de uso de los mismos
WO2015047982A2 (en) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
GB201322512D0 (en) * 2013-12-19 2014-02-05 Glaxosmithkline Ip Dev Ltd Novel compounds
CN106061944A (zh) * 2014-01-24 2016-10-26 普渡制药公司 吡啶类和嘧啶类物质及其用途
JP2017520610A (ja) * 2014-07-17 2017-07-27 シーエイチディーアイ ファウンデーション,インコーポレーテッド Hiv関連障害を治療するための方法及び組成物
AU2016215432B2 (en) 2015-02-02 2020-07-30 Valo Early Discovery, Inc. 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
KR20180002730A (ko) * 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
AU2016258188B2 (en) * 2015-05-07 2021-08-26 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
CN110381963A (zh) 2016-10-13 2019-10-25 朱诺治疗学股份有限公司 涉及色氨酸代谢途径调节剂的免疫治疗方法和组合物
US11173156B2 (en) * 2019-06-11 2021-11-16 Chdi Foundation, Inc. Solid forms of a kynurenine-3-monooxygenase inhibitor
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
KR20230054685A (ko) 2020-08-06 2023-04-25 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질 이미징을 위한 헤테로바이아릴 화합물 및 이미징제

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707560A (en) 1970-10-05 1972-12-26 Pfizer Certain 4-amino-6-aryl-pyrimidines
US3908012A (en) 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
FR2204406A1 (en) 1972-10-26 1974-05-24 Delalande Sa 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.
US3950525A (en) 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
US3935202A (en) 1974-03-18 1976-01-27 American Home Products Corporation 3-(4-biphenylylcarbonyl)propionamido cephalosporin derivatives
US4634689A (en) 1985-10-31 1987-01-06 Schering Corporation Phosphinylalkanoyl imino acids
DE3609596A1 (de) 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
WO1988003136A1 (fr) 1986-10-27 1988-05-05 Yoshitomi Pharmaceutical Industries, Ltd. Composes de piperazine et leur utilisation medicinale
ZW21687A1 (en) 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
GB8629711D0 (en) * 1986-12-12 1987-01-21 Hoffmann La Roche Triazine derivatives
JPH01113377A (ja) 1987-10-23 1989-05-02 Yoshitomi Pharmaceut Ind Ltd ピペラジン化合物
MX16687A (es) 1988-07-07 1994-01-31 Ciba Geigy Ag Compuestos de biarilo y procedimiento para su preparacion.
US5102904A (en) 1989-12-08 1992-04-07 American Cyanamid Company N-oxygenated arylpyrrole insecticidal, acaricidal and nematicidal agents and use thereas
AU644159B2 (en) 1990-05-17 1993-12-02 Novartis Ag 2-anilino-4-cyanopyrimidine derivatives
DE4103695A1 (de) 1991-02-07 1992-08-13 Basf Ag Oximether und diese enthaltende fungizide
US5334720A (en) 1991-03-07 1994-08-02 Fisons Corporation Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
WO1995023135A1 (en) 1991-03-07 1995-08-31 Fisons Corporation Diphenyl-2-piperidinone and -2-pyrrolidinone derivatives having anti-convulsant and neuroprotective activity
JPH0741459A (ja) 1993-07-29 1995-02-10 Sumitomo Pharmaceut Co Ltd 新規エラスターゼ阻害剤
EP0656348B1 (de) 1993-12-03 2000-05-03 F. Hoffmann-La Roche Ag Essigsäurederivate als Arzneimittel
US5338739A (en) 1994-03-10 1994-08-16 Hoechst-Roussel Pharmaceuticals Inc. (Pyrrolidinyl)phenyl carbamates, compositions and use
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
EP0861239B1 (de) 1995-11-17 2003-02-12 Bayer CropScience AG Biphenylether-oxazoline und ihre verwendung als schädlingsbekämpfungsmittel
PL327494A1 (en) 1995-12-22 1998-12-21 Warner Lambert Co Aromatic keto-carboxylic acids and their derivatives as inhibitors of matrix metalloproteinases
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
US5877193A (en) * 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
WO1998009940A1 (en) 1996-09-04 1998-03-12 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
MXPA99001974A (es) 1996-12-09 2002-03-27 Warner Lambert Co Metodo para tratar y prevenir fallas cardiacas y dilatacion ventricular.
DE69727695T2 (de) 1996-12-17 2005-02-10 Warner-Lambert Co. Llc Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung
WO1998035967A2 (en) 1997-02-18 1998-08-20 Neurocrine Biosciences, Inc. Biazacyclic crf antagonists
PL335235A1 (en) 1997-02-19 2000-04-10 Berlex Lab N-heterocyclic derivatives as nos inhibitors
US5925639A (en) 1997-06-17 1999-07-20 Schering Corporation Keto amide derivatives useful as farnesyl protein transferase inhibitors
AU9663798A (en) 1997-10-06 1999-04-27 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
AU1110799A (en) 1997-10-29 1999-05-17 Warner-Lambert Company Method of inhibiting metastases of cancer cells
HUP0100427A3 (en) 1997-12-23 2002-11-28 Warner Lambert Co Ace inhibitor-mmp inhibitor combinations
US6169103B1 (en) 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
HUP0103714A3 (en) 1998-05-11 2003-05-28 Takeda Pharmaceutical Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity, medicaments containing them and their use
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
DE69912823T2 (de) 1998-09-25 2004-09-23 Astrazeneca Ab Benzamid-derivate und ihre verwendung als cytokine inhibitoren
JP4183350B2 (ja) 1998-10-28 2008-11-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 フェニルピロリジノン誘導体
US6541521B1 (en) 1999-07-12 2003-04-01 Warner-Lambert Company Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
CA2389208A1 (en) 1999-10-29 2001-05-10 Takeda Chemical Industries, Ltd. Process for the preparation of oxyiminoalkanoic acid derivatives
AU1303201A (en) 1999-11-10 2001-06-06 Takeda Chemical Industries Ltd. Alkoxyiminoalkanoic acid derivatives
CA2390932A1 (en) 1999-11-10 2001-05-17 Takeda Chemical Industries, Ltd. Body weight gain inhibitors
GB0003671D0 (en) 2000-02-17 2000-04-05 Univ Cardiff Diphenyl-substituted lower alkanes
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2002040458A1 (en) 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Isoxazole derivatives
US20040077557A1 (en) 2000-12-21 2004-04-22 Sulejman Ali Macrolide antibiotics
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
JP2002241358A (ja) 2001-02-15 2002-08-28 Nippon Soda Co Ltd オキシム基を有する化合物及び殺虫・殺ダニ剤
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
WO2002098840A1 (en) 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
WO2002100332A2 (en) 2001-06-08 2002-12-19 Cytokine Pharmasciences, Inc. Isoxazoline compounds having mif antagonist activity
US6552188B2 (en) 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
ATE396186T1 (de) 2001-10-04 2008-06-15 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
AU2002359714B2 (en) 2001-12-18 2006-12-21 Merck Sharp & Dohme Corp. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
US6949542B2 (en) 2002-02-06 2005-09-27 Hoffman-La Roche Inc. Dihydro-benzo[b][1,4]diazepin-2-one derivatives
JP2005535710A (ja) 2002-08-09 2005-11-24 トランス テック ファーマ,インコーポレイテッド アリールおよびヘテロアリール化合物ならびに凝固を調節する方法
WO2004026833A1 (ja) 2002-09-20 2004-04-01 Takeda Pharmaceutical Company Limited 環状アミン化合物、その製造法および用途
AU2003280558A1 (en) 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
CL2003002353A1 (es) 2002-11-15 2005-02-04 Vertex Pharma Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
AU2003293129B2 (en) 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
CA2510298A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
EP1581493A1 (en) 2002-12-30 2005-10-05 Eli Lilly And Company Factor xa inhibitors
US20060293339A1 (en) 2003-03-24 2006-12-28 Chakravarty Prasun K Biaryl substituted 6-membered heterocycles as sodium channel blockers
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
CN1566065A (zh) 2003-06-27 2005-01-19 中国医学科学院药物研究所 α位杂原子取代的γ芳基丁本酮酸衍生物及其制法和其药物组合物与用途
SE0301963D0 (sv) 2003-07-02 2003-07-02 Astrazeneca Ab New compounds
JP2007500128A (ja) 2003-07-25 2007-01-11 アムジエン・インコーポレーテツド 置換複素環式化合物及び使用方法
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
GB0323581D0 (en) 2003-10-08 2003-11-12 Glaxo Group Ltd Novel compounds
US20070099938A1 (en) 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
WO2005042498A2 (en) 2003-10-31 2005-05-12 Neurogen Corporation 4-amino (aza) quinoline derivatives as capsaicin receptor agonists
EP1715867A4 (en) 2004-02-12 2009-04-15 Merck & Co Inc BIPYRIDYLAMIDE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
GB0403155D0 (en) 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
EP1727542A4 (en) 2004-03-26 2009-08-05 Cytokine Pharmasciences Inc COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE FOR INHIBITING MACROPHAGE MIGRATION INHIBITION FACTOR
EP2332940B1 (en) 2004-03-30 2012-10-31 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
WO2006000371A2 (en) 2004-06-28 2006-01-05 F.Hoffmann-La Roche Ag Pyrimidine derivatives as 11beta-hsd1 inhibitors
EP1783116B1 (en) 2004-08-27 2009-08-26 Astellas Pharma Inc. 2-phenylpyridine derivative
WO2006021458A2 (en) 2004-08-27 2006-03-02 Gpc Biotech Ag Pyrimidine derivatives
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
CA2588633A1 (en) 2004-12-07 2006-06-15 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
US20060178388A1 (en) 2005-02-04 2006-08-10 Wrobleski Stephen T Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
BRPI0608581A2 (pt) 2005-03-14 2010-01-19 Transtech Pharma Inc derivados de benzazol, composiÇÕes e mÉtodos de uso como inibidores de b-secretase
CN103173402A (zh) 2005-06-07 2013-06-26 洛克菲勒大学 胰腺β细胞增殖的刺激
EP2388263A1 (en) 2005-08-04 2011-11-23 Sirtris Pharmaceuticals, Inc. Imidazo[2,1-b]thiazole derivatives as sirtuin modulators
WO2007017289A2 (en) 2005-08-10 2007-02-15 Bayer Schering Pharma Aktiengesellschaft Acyltryptophanols for fertility control
US20070060573A1 (en) 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
US20090221547A1 (en) 2005-08-23 2009-09-03 Irm Llc Immunosuppressant Compounds and Compositions
TW200745055A (en) 2005-09-23 2007-12-16 Organon Nv 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
CN102775396B (zh) 2005-11-08 2014-10-08 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的杂环调控剂
EP1960367A2 (en) 2005-12-05 2008-08-27 Boehringer Ingelheim International GmbH Substituted pyrazole compounds useful as soluble epoxide hydrolase inhibitors
JP2009519966A (ja) 2005-12-14 2009-05-21 ブリストル−マイヤーズ スクイブ カンパニー セリンプロテアーゼ阻害剤として有用な6員ヘテロ環
WO2007087637A2 (en) 2006-01-26 2007-08-02 Washington State University Research Foundation Compositions and methods using matrix metalloproteinase (mmp) inhibitors for treating cognitive impairment characterized by persistent or sustained mmp expression and/or activity
US7951824B2 (en) 2006-02-17 2011-05-31 Hoffman-La Roche Inc. 4-aryl-pyridine-2-carboxyamide derivatives
ES2303758B1 (es) * 2006-02-20 2009-08-13 Laboratorios Almirall S.A. Nuevos derivados de piridin-3-amina.
MX2008010646A (es) * 2006-02-24 2008-10-14 Astellas Pharma Inc Agente para tratar o prevenir ulcera digestiva.
JP2007230963A (ja) 2006-03-03 2007-09-13 Daiso Co Ltd 2,4−ジ置換ピリジンの製造法
BRPI0713350B1 (pt) 2006-06-26 2022-04-12 Akebia Therapeutics Inc Composto, e, composição
GB0614579D0 (en) 2006-07-21 2006-08-30 Black James Foundation Pyrimidine derivatives
CL2007002315A1 (es) 2006-08-10 2008-02-22 Glaxo Group Ltd Compuestos derivados de piridina;composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades o trastornos que comprenden el dolor y/o sindrome del intestino irritable.
EP2054397B1 (en) 2006-08-16 2015-10-07 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Small molecule inhibitors of kynurenine-3-monooxygenase
EP2054056A4 (en) 2006-08-16 2010-08-25 J David Gladstone Inst A Testa SMALL MOLECULAR INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
EP2065369A4 (en) 2006-08-23 2011-12-28 Astellas Pharma Inc UREA CONNECTION OR SALT THEREOF
ATE532770T1 (de) 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd Imidazolderivat
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20080077419A1 (en) 2006-09-27 2008-03-27 Santiago Pamela M System And Method For Training Employees Of An Organization To Align Their Job Activities To Achieving The Organization's Strategic Objectives
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US8044209B2 (en) 2006-10-12 2011-10-25 Novartis Ag Pyrrolydine derivatives as IAP inhibitors
WO2008095852A1 (en) 2007-02-08 2008-08-14 Respiratorius Ab Bronchorelaxing arylamides
JP2008266634A (ja) * 2007-03-29 2008-11-06 Sumitomo Chemical Co Ltd 化合物、光電変換素子及び光電気化学電池
US20100101643A1 (en) * 2007-03-29 2010-04-29 Sumitomo Chemical Company, Limited Compound, photoelectric converter and photoelectrochemical cell
JP2010523579A (ja) 2007-04-02 2010-07-15 インスティテュート フォア ワンワールド ヘルス Cftr阻害剤化合物およびそれらの使用
EP2002834A1 (de) 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors
TWI444379B (zh) 2007-06-29 2014-07-11 Sunesis Pharmaceuticals Inc 有用於作為Raf激酶抑制劑之化合物
PE20091309A1 (es) 2007-12-21 2009-09-30 Astrazeneca Ab Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
JP2009280521A (ja) 2008-05-22 2009-12-03 Daiso Co Ltd 2,4−ジ置換ピリジンの製造法
JP2011184298A (ja) 2008-06-02 2011-09-22 Sanwa Kagaku Kenkyusho Co Ltd 新規化合物及びその医薬用途
US20110118262A1 (en) 2008-07-08 2011-05-19 Boehringer Ingelheim International Gmbh Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors
US20110230428A1 (en) 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MX2010014337A (es) 2008-07-25 2011-02-15 Lundbeck & Co As H Derivados de adamantil diamida y usos de los mismos.
KR20110092266A (ko) * 2008-08-04 2011-08-17 씨에이치디아이 파운데이션, 인코포레이티드 소정 키누레닌-3-모노옥시게나아제 억제제, 약학적 조성물, 및 그의 사용 방법
WO2010017132A1 (en) 2008-08-04 2010-02-11 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
GB0815369D0 (en) * 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
JP5587784B2 (ja) 2008-10-15 2014-09-10 キッセイ薬品工業株式会社 縮合複素環誘導体及びその医薬用途
EP2340243B1 (en) * 2008-10-17 2014-10-08 Boehringer Ingelheim International GmbH Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
KR20110091537A (ko) * 2008-11-13 2011-08-11 바이엘 크롭사이언스 아게 살진균제로서의 치환 (피리딜)-아지닐아민 유도체
NZ593473A (en) * 2009-01-12 2013-02-22 Pfizer Ltd Sulfonamide derivatives
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
TW201040166A (en) * 2009-04-07 2010-11-16 Astrazeneca Ab Isoxazol-3(2H)-one analogs as therapeutic agents
EA020017B1 (ru) * 2009-04-30 2014-08-29 Новартис Аг Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ
US20120041009A1 (en) 2009-05-18 2012-02-16 Sumitomo Chemical Company, Limited Pyrimidine compound and its use in pest control
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
TWI423962B (zh) * 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
PH12012500713A1 (en) 2009-10-14 2012-11-26 Merck Sharp & Dohme Substituted piperidines that increase p53 activity and the uses thereof
EP2490530A4 (en) 2009-10-22 2014-01-22 Univ Washington COMPOUNDS AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS
US8946197B2 (en) 2009-11-16 2015-02-03 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
US8883785B2 (en) 2010-01-25 2014-11-11 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP5826773B2 (ja) 2010-02-27 2015-12-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH ビスアリール−結合アリールトリアゾロン及びその用途
CN102985418B (zh) 2010-07-02 2015-09-09 吉利德科学股份有限公司 凋亡信号调节激酶抑制剂
KR20130056345A (ko) 2010-09-17 2013-05-29 퍼듀 퍼머 엘피 피리딘 화합물 및 그의 용도
EP2796456A1 (en) 2010-12-09 2014-10-29 Amgen Inc. Bicyclic compounds as Pim inhibitors
HK1198619A1 (en) 2011-07-28 2015-05-22 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MY166890A (en) * 2011-08-30 2018-07-24 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2972419T3 (es) 2012-04-05 2024-06-12 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas y métodos de uso de los mismos
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2015047982A2 (en) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2017520610A (ja) 2014-07-17 2017-07-27 シーエイチディーアイ ファウンデーション,インコーポレーテッド Hiv関連障害を治療するための方法及び組成物

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