FR2204406A1 - 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc. - Google Patents

1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.

Info

Publication number
FR2204406A1
FR2204406A1 FR7238089A FR7238089A FR2204406A1 FR 2204406 A1 FR2204406 A1 FR 2204406A1 FR 7238089 A FR7238089 A FR 7238089A FR 7238089 A FR7238089 A FR 7238089A FR 2204406 A1 FR2204406 A1 FR 2204406A1
Authority
FR
France
Prior art keywords
phenyl
hypotensive
antiinflammatory
analgesic
aminocarbonylpropan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7238089A
Other languages
French (fr)
Other versions
FR2204406B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7238089A priority Critical patent/FR2204406A1/en
Publication of FR2204406A1 publication Critical patent/FR2204406A1/en
Application granted granted Critical
Publication of FR2204406B1 publication Critical patent/FR2204406B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Title cpds. are of formula (I):- (where is dialkylamino (1-4C alkyls) or pyrrolidino, morpholino, piperidino, hexamethyleneimino, 4-phenylpiperazino, 4-methylpiperazino; R is H, or -CO.NHR3 where, when is dialkylamino3 or unsubstd. heterocyclic, R3 is phenyl opt. substd. by halogen, or 1-4C alkoxy is 4-phenylpiperazino or 4-methylpiperazino R3 is Me or allyl). The oximes are inters. for the carbamates (R = -CONHR3) which have analgesic, antiinflammatory, sedative, tranquillising, antidepressant, hypotensive, vasodilator, cardiovascular analeptic, anticholinergic, spasmolytic and antiulcer activity. Prepn. is by conventional treatment of the appropriate ketone with hydroxylamine and conversion into the the carbamate with phenyl isocyanates.
FR7238089A 1972-10-26 1972-10-26 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc. Granted FR2204406A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7238089A FR2204406A1 (en) 1972-10-26 1972-10-26 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7238089A FR2204406A1 (en) 1972-10-26 1972-10-26 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.

Publications (2)

Publication Number Publication Date
FR2204406A1 true FR2204406A1 (en) 1974-05-24
FR2204406B1 FR2204406B1 (en) 1975-11-28

Family

ID=9106284

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7238089A Granted FR2204406A1 (en) 1972-10-26 1972-10-26 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.

Country Status (1)

Country Link
FR (1) FR2204406A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300325A2 (en) * 1987-07-20 1989-01-25 COMETEC S.r.l. Compositions for promoting growth of animals
EP0470805A1 (en) * 1990-08-08 1992-02-12 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2016166480A1 (en) * 2015-04-16 2016-10-20 Metabrain Research Derivatives used in the treatment of muscle atrophy
US9981918B2 (en) 2011-08-30 2018-05-29 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US10258621B2 (en) 2014-07-17 2019-04-16 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805716A1 (en) * 1967-11-02 1969-07-24 Usv Pharma Corp Carbamoyloxime and process for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805716A1 (en) * 1967-11-02 1969-07-24 Usv Pharma Corp Carbamoyloxime and process for their preparation

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300325A2 (en) * 1987-07-20 1989-01-25 COMETEC S.r.l. Compositions for promoting growth of animals
EP0300325A3 (en) * 1987-07-20 1990-10-17 Cometec S.R.L. Compositions for promoting growth of animals
EP0470805A1 (en) * 1990-08-08 1992-02-12 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9981918B2 (en) 2011-08-30 2018-05-29 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US10258621B2 (en) 2014-07-17 2019-04-16 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
WO2016166480A1 (en) * 2015-04-16 2016-10-20 Metabrain Research Derivatives used in the treatment of muscle atrophy
FR3035105A1 (en) * 2015-04-16 2016-10-21 Metabrain Res DERIVATIVES USEFUL IN THE TREATMENT OF MUSCLE ATROPHY
US10350184B2 (en) 2015-04-16 2019-07-16 Metabrain Research Derivatives used in the treatment of muscle atrophy
RU2715553C2 (en) * 2015-04-16 2020-03-02 Метабрейн Рисёч Derivatives used for treating muscular atrophy

Also Published As

Publication number Publication date
FR2204406B1 (en) 1975-11-28

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Legal Events

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