FR2244459A1 - 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics - Google Patents

2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Info

Publication number
FR2244459A1
FR2244459A1 FR7333831A FR7333831A FR2244459A1 FR 2244459 A1 FR2244459 A1 FR 2244459A1 FR 7333831 A FR7333831 A FR 7333831A FR 7333831 A FR7333831 A FR 7333831A FR 2244459 A1 FR2244459 A1 FR 2244459A1
Authority
FR
France
Prior art keywords
alkyl
broncho
vasodilating
sedatives
diuretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7333831A
Other languages
French (fr)
Other versions
FR2244459B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7333831A priority Critical patent/FR2244459A1/en
Priority to CH1140174A priority patent/CH593266A5/xx
Priority to BE147794A priority patent/BE819057A/en
Priority to LU70791A priority patent/LU70791A1/xx
Priority to GB3755074A priority patent/GB1430729A/en
Priority to US05/502,285 priority patent/US3978055A/en
Priority to ES429869A priority patent/ES429869A1/en
Priority to ZA00745741A priority patent/ZA745741B/en
Priority to JP49105900A priority patent/JPS5088079A/ja
Priority to DE19742444426 priority patent/DE2444426A1/en
Priority to AU73441/74A priority patent/AU483869B2/en
Priority to CA209,631A priority patent/CA1008074A/en
Priority to SU742062977A priority patent/SU645569A3/en
Priority to SE7411806A priority patent/SE410600B/en
Priority to IT69833/74A priority patent/IT1062796B/en
Priority to NL7412494A priority patent/NL7412494A/en
Publication of FR2244459A1 publication Critical patent/FR2244459A1/en
Priority to US05/714,472 priority patent/US4025514A/en
Priority to US05/714,473 priority patent/US4041030A/en
Application granted granted Critical
Publication of FR2244459B1 publication Critical patent/FR2244459B1/fr
Priority to SU772558803A priority patent/SU698531A3/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Acylaminopyrimidines of formula (I) (where Ar is phenul opt. substd. by one or more halogens, CF3, OCH2O, one or more MeO, 1-4C alkyl or Me2N; R is CONRMR2 and R1 and R2 are H or 1-4C alkyl or NR1R2 is pyrrolidino, morpholino, piperidino or piperazino opt. N-substd. by 1-4C alkyl or phenyl, or R i s(O(CH2)n NR3R4 and R3 and R4 are 1-3C alkyl or NR3R4 is morpholino, pyrrolidino, ino, piperidino or hexamethyleneimino and n is 1-5, or R is is COOR5 and R5 is 1-4C alkyl, 2-3-di-hydroxypropyl or 2, 2-dimethyldioxolon-4-yl methyl or R is hydroxy carbonyl methyl) are used as e.g. sedatives, antiinflammatory, anti-ulcer, vasodilating, anti-broncho-constructing and anticholinergic agents and diuretics.
FR7333831A 1973-09-20 1973-09-20 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics Granted FR2244459A1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR7333831A FR2244459A1 (en) 1973-09-20 1973-09-20 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics
CH1140174A CH593266A5 (en) 1973-09-20 1974-08-21
BE147794A BE819057A (en) 1973-09-20 1974-08-21 NEW ARYLAMINO PYRIMIDINE DERIVATIVES
LU70791A LU70791A1 (en) 1973-09-20 1974-08-23
GB3755074A GB1430729A (en) 1973-09-20 1974-08-28 Arylamino pyrimidinic derivatives their process ff preparation and their therapeutic application
US05/502,285 US3978055A (en) 1973-09-20 1974-09-03 Arylamino pyrimidinic derivatives
ES429869A ES429869A1 (en) 1973-09-20 1974-09-07 Arylamino pyrimidinic derivatives
ZA00745741A ZA745741B (en) 1973-09-20 1974-09-10 Novel arylamino pyrimidinic derivatives
JP49105900A JPS5088079A (en) 1973-09-20 1974-09-13
DE19742444426 DE2444426A1 (en) 1973-09-20 1974-09-17 ARYLAMINOPYRIMIDINE COMPOUNDS, THE METHOD OF PREPARING THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
AU73441/74A AU483869B2 (en) 1973-09-20 1974-09-18 Novel arylamino pyrimidinic derivatives their process of preparation and their therapeutic application
CA209,631A CA1008074A (en) 1973-09-20 1974-09-18 Arylamino pyrimidinic derivatives, method of preparation and therapeutical applications
SU742062977A SU645569A3 (en) 1973-09-20 1974-09-19 Method of obtaining derivatives of 4-arylamino-6-methyl pyrimidine
SE7411806A SE410600B (en) 1973-09-20 1974-09-19 WAY TO PRODUCE NEW ARYLAMINOPYRIMIDINE DERIVATIVES
IT69833/74A IT1062796B (en) 1973-09-20 1974-09-19 ARILAMINO PYRIMIDINIC DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
NL7412494A NL7412494A (en) 1973-09-20 1974-09-20 PROCESS FOR THE PREPARATION OF NEW ARYL-AMINOPYRIMIDINE COMPOUNDS.
US05/714,472 US4025514A (en) 1973-09-20 1976-08-16 Arylamino pyrimidinic derivatives
US05/714,473 US4041030A (en) 1973-09-20 1976-08-16 Arylamino pyrimidinic derivatives
SU772558803A SU698531A3 (en) 1973-09-20 1977-12-28 Method of preparing 4-arylamino-6-methylpyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7333831A FR2244459A1 (en) 1973-09-20 1973-09-20 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Publications (2)

Publication Number Publication Date
FR2244459A1 true FR2244459A1 (en) 1975-04-18
FR2244459B1 FR2244459B1 (en) 1977-09-02

Family

ID=9125341

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7333831A Granted FR2244459A1 (en) 1973-09-20 1973-09-20 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Country Status (4)

Country Link
BE (1) BE819057A (en)
FR (1) FR2244459A1 (en)
SU (1) SU698531A3 (en)
ZA (1) ZA745741B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357252A2 (en) * 1976-07-07 1978-02-03 Delalande Sa (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.
EP1549316A1 (en) * 2002-09-10 2005-07-06 Scios Inc. INHIBITORS OF TFG&bgr;
WO2017068070A1 (en) * 2015-10-20 2017-04-27 Vassilatis Demetrios K Nurr1:rxr activating compounds for simultaneous treatment of symptoms and pathology of parkinson's disease

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2357252A2 (en) * 1976-07-07 1978-02-03 Delalande Sa (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.
EP1549316A1 (en) * 2002-09-10 2005-07-06 Scios Inc. INHIBITORS OF TFG&bgr;
EP1549316A4 (en) * 2002-09-10 2008-04-09 Scios Inc INHIBITORS OF TFGbeta
WO2017068070A1 (en) * 2015-10-20 2017-04-27 Vassilatis Demetrios K Nurr1:rxr activating compounds for simultaneous treatment of symptoms and pathology of parkinson's disease
LU92852B1 (en) * 2015-10-20 2017-05-02 Athanasios Spathis NURR1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinsons disease
US10946019B2 (en) 2015-10-20 2021-03-16 Vassilatis Demetrios K Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease

Also Published As

Publication number Publication date
BE819057A (en) 1975-02-21
SU698531A3 (en) 1979-11-15
ZA745741B (en) 1975-10-29
FR2244459B1 (en) 1977-09-02

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