FR2265386A2 - 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics - Google Patents

2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Info

Publication number
FR2265386A2
FR2265386A2 FR7410327A FR7410327A FR2265386A2 FR 2265386 A2 FR2265386 A2 FR 2265386A2 FR 7410327 A FR7410327 A FR 7410327A FR 7410327 A FR7410327 A FR 7410327A FR 2265386 A2 FR2265386 A2 FR 2265386A2
Authority
FR
France
Prior art keywords
alkyl
broncho
vasodilating
sedatives
diuretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7410327A
Other languages
French (fr)
Other versions
FR2265386B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7410327A priority Critical patent/FR2265386A2/en
Priority to CH1140174A priority patent/CH593266A5/xx
Priority to LU70791A priority patent/LU70791A1/xx
Priority to GB3755074A priority patent/GB1430729A/en
Priority to US05/502,285 priority patent/US3978055A/en
Priority to ES429869A priority patent/ES429869A1/en
Priority to JP49105900A priority patent/JPS5088079A/ja
Priority to DE19742444426 priority patent/DE2444426A1/en
Priority to AU73441/74A priority patent/AU483869B2/en
Priority to CA209,631A priority patent/CA1008074A/en
Priority to SU742062977A priority patent/SU645569A3/en
Priority to IT69833/74A priority patent/IT1062796B/en
Priority to SE7411806A priority patent/SE410600B/en
Priority to NL7412494A priority patent/NL7412494A/en
Publication of FR2265386A2 publication Critical patent/FR2265386A2/en
Priority to US05/714,473 priority patent/US4041030A/en
Priority to US05/714,472 priority patent/US4025514A/en
Application granted granted Critical
Publication of FR2265386B2 publication Critical patent/FR2265386B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Acylaminopyrimidines of formula (I) (where Ar is phenul opt. substd. by one or more halogens, CF3, OCH2O, one or more MeO, 1-4C alkyl or Me2N; R is CONRMR2 and R1 and R2 are H or 1-4C alkyl or NR1R2 is pyrrolidino, morpholino, piperidino or piperazino opt. N-substd. by 1-4C alkyl or phenyl, or R i s(O(CH2)n NR3R4 and R3 and R4 are 1-3C alkyl or NR3R4 is morpholino, pyrrolidino, ino, piperidino or hexamethyleneimino and n is 1-5, or R is is COOR5 and R5 is 1-4C alkyl, 2-3-di-hydroxypropyl or 2, 2-dimethyldioxolon-4-yl methyl or R is hydroxy carbonyl methyl) are used as e.g. sedatives, antiinflammatory, anti-ulcer, vasodilating, anti-broncho-constructing and anticholinergic agents and diuretics.
FR7410327A 1973-09-20 1974-03-26 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics Granted FR2265386A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR7410327A FR2265386A2 (en) 1974-03-26 1974-03-26 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics
CH1140174A CH593266A5 (en) 1973-09-20 1974-08-21
LU70791A LU70791A1 (en) 1973-09-20 1974-08-23
GB3755074A GB1430729A (en) 1973-09-20 1974-08-28 Arylamino pyrimidinic derivatives their process ff preparation and their therapeutic application
US05/502,285 US3978055A (en) 1973-09-20 1974-09-03 Arylamino pyrimidinic derivatives
ES429869A ES429869A1 (en) 1973-09-20 1974-09-07 Arylamino pyrimidinic derivatives
JP49105900A JPS5088079A (en) 1973-09-20 1974-09-13
DE19742444426 DE2444426A1 (en) 1973-09-20 1974-09-17 ARYLAMINOPYRIMIDINE COMPOUNDS, THE METHOD OF PREPARING THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
AU73441/74A AU483869B2 (en) 1973-09-20 1974-09-18 Novel arylamino pyrimidinic derivatives their process of preparation and their therapeutic application
CA209,631A CA1008074A (en) 1973-09-20 1974-09-18 Arylamino pyrimidinic derivatives, method of preparation and therapeutical applications
SU742062977A SU645569A3 (en) 1973-09-20 1974-09-19 Method of obtaining derivatives of 4-arylamino-6-methyl pyrimidine
IT69833/74A IT1062796B (en) 1973-09-20 1974-09-19 ARILAMINO PYRIMIDINIC DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
SE7411806A SE410600B (en) 1973-09-20 1974-09-19 WAY TO PRODUCE NEW ARYLAMINOPYRIMIDINE DERIVATIVES
NL7412494A NL7412494A (en) 1973-09-20 1974-09-20 PROCESS FOR THE PREPARATION OF NEW ARYL-AMINOPYRIMIDINE COMPOUNDS.
US05/714,473 US4041030A (en) 1973-09-20 1976-08-16 Arylamino pyrimidinic derivatives
US05/714,472 US4025514A (en) 1973-09-20 1976-08-16 Arylamino pyrimidinic derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7410327A FR2265386A2 (en) 1974-03-26 1974-03-26 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Publications (2)

Publication Number Publication Date
FR2265386A2 true FR2265386A2 (en) 1975-10-24
FR2265386B2 FR2265386B2 (en) 1978-09-29

Family

ID=9136820

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7410327A Granted FR2265386A2 (en) 1973-09-20 1974-03-26 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Country Status (1)

Country Link
FR (1) FR2265386A2 (en)

Also Published As

Publication number Publication date
FR2265386B2 (en) 1978-09-29

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