FR2357252A2 - (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc. - Google Patents

(2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.

Info

Publication number
FR2357252A2
FR2357252A2 FR7620775A FR7620775A FR2357252A2 FR 2357252 A2 FR2357252 A2 FR 2357252A2 FR 7620775 A FR7620775 A FR 7620775A FR 7620775 A FR7620775 A FR 7620775A FR 2357252 A2 FR2357252 A2 FR 2357252A2
Authority
FR
France
Prior art keywords
arylamino
aryl
anticholinergics
sedatives
diuretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7620775A
Other languages
French (fr)
Other versions
FR2357252B2 (en
Inventor
Claude Fauran
Guy Bourgery
Guy Raynaud
Claude Gouret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7620775A priority Critical patent/FR2357252A2/en
Priority to US05/714,473 priority patent/US4041030A/en
Priority to BE178577A priority patent/BE855867R/en
Priority to GB25894/77A priority patent/GB1548858A/en
Priority to ZA00773740A priority patent/ZA773740B/en
Priority to GR53766A priority patent/GR60840B7/en
Priority to CH765677A priority patent/CH611283A5/en
Priority to IT25031/77A priority patent/IT1114810B/en
Priority to DE19772729360 priority patent/DE2729360A1/en
Priority to LU77660A priority patent/LU77660A1/xx
Priority to ES460411A priority patent/ES460411A2/en
Priority to JP8090477A priority patent/JPS5312877A/en
Priority to NL7707531A priority patent/NL7707531A/en
Priority to SE7707880A priority patent/SE7707880L/en
Priority to AU26808/77A priority patent/AU2680877A/en
Priority to SU772499407A priority patent/SU679143A3/en
Publication of FR2357252A2 publication Critical patent/FR2357252A2/en
Application granted granted Critical
Publication of FR2357252B2 publication Critical patent/FR2357252B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-Aryl-4-arylamino-6-methylpyrimidines of formula (I) are new: In the formula, (a) X is COR; Y is H; and (1) Ar is p-CIC6H4 and R is morpholino or piperidino; (2) Ar is o-CIC6H4 and R is morpholino; (3) Ar is m-FC6H4 and R is piperidino; (4) Ar is 3,4-OCH2OC6H3 or 3,4,5-(MeO)3-C6H2 and R is morpholino or NH2. Or (b) X is morpholinocarbonyl; Y is H or Me; and Ar is Ph opt. substd. by a halogen. Used as sedative, antiulcer, antibronchoconstrictive, anticholinergic, diuretic, analgesic, myorelaxant and anti-anoxemia agents. Dose: 100-3000 mg./day or orally.
FR7620775A 1973-09-20 1976-07-07 (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc. Granted FR2357252A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR7620775A FR2357252A2 (en) 1976-07-07 1976-07-07 (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.
US05/714,473 US4041030A (en) 1973-09-20 1976-08-16 Arylamino pyrimidinic derivatives
BE178577A BE855867R (en) 1976-07-07 1977-06-20 NEW ARYLAMINO PYRIMIDINE DERIVATIVES
GB25894/77A GB1548858A (en) 1976-07-07 1977-06-21 Arylaminopyrimidine derivatives their method of preparation and their application in therapeutics
ZA00773740A ZA773740B (en) 1976-07-07 1977-06-22 Novel arylaminopyrimidine derivatives,their method of preparation and their application in therapeutics
GR53766A GR60840B7 (en) 1974-09-20 1977-06-22 Preparation process of novel arylaminopyrimidin derivatives
CH765677A CH611283A5 (en) 1976-07-07 1977-06-22 Process for the preparation of arylaminopyrimidine derivatives
IT25031/77A IT1114810B (en) 1976-07-07 1977-06-24 ARYLAMINOPYRIMIDINAL DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
DE19772729360 DE2729360A1 (en) 1976-07-07 1977-06-29 ARYLAMINOPYRIMIDE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
LU77660A LU77660A1 (en) 1976-07-07 1977-06-30
ES460411A ES460411A2 (en) 1976-07-07 1977-07-05 Arylaminopyrimidine derivatives their method of preparation and their application in therapeutics
JP8090477A JPS5312877A (en) 1976-07-07 1977-07-06 Production of aryaminopiridine derivatives
NL7707531A NL7707531A (en) 1976-07-07 1977-07-06 PROCEDURE FOR THE PREPARATION OF A MEDICINAL PRODUCT, AS WELL AS FOR THE PREPARATION OF NEW ARYLAMINOPYRIMIDINE COMPOUNDS.
SE7707880A SE7707880L (en) 1976-07-07 1977-07-06 NEW ARYLAMINOPYRIMIDE INDIVIDUALS AND WAYS TO PREPARE THE SAME
AU26808/77A AU2680877A (en) 1976-07-07 1977-07-06 Arylaminopyrimidine derivatives
SU772499407A SU679143A3 (en) 1976-07-07 1977-07-06 Method of producing arylaminopyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7620775A FR2357252A2 (en) 1976-07-07 1976-07-07 (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.

Publications (2)

Publication Number Publication Date
FR2357252A2 true FR2357252A2 (en) 1978-02-03
FR2357252B2 FR2357252B2 (en) 1978-12-15

Family

ID=9175367

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7620775A Granted FR2357252A2 (en) 1973-09-20 1976-07-07 (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.

Country Status (3)

Country Link
BE (1) BE855867R (en)
FR (1) FR2357252A2 (en)
ZA (1) ZA773740B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244459A1 (en) * 1973-09-20 1975-04-18 Delalande Sa 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244459A1 (en) * 1973-09-20 1975-04-18 Delalande Sa 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Also Published As

Publication number Publication date
ZA773740B (en) 1978-05-30
BE855867R (en) 1977-12-20
FR2357252B2 (en) 1978-12-15

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