CH611283A5 - Process for the preparation of arylaminopyrimidine derivatives - Google Patents

Process for the preparation of arylaminopyrimidine derivatives

Info

Publication number
CH611283A5
CH611283A5 CH765677A CH765677A CH611283A5 CH 611283 A5 CH611283 A5 CH 611283A5 CH 765677 A CH765677 A CH 765677A CH 765677 A CH765677 A CH 765677A CH 611283 A5 CH611283 A5 CH 611283A5
Authority
CH
Switzerland
Prior art keywords
representing
phenyl ring
derivatives
arylaminopyrimidine
preparation
Prior art date
Application number
CH765677A
Inventor
Claude Fauran
Guy Raynaud
Claude Gouret
Guy Bourgery
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7620775A external-priority patent/FR2357252A2/en
Priority claimed from FR7718471A external-priority patent/FR2394543A2/en
Application filed by Delalande Sa filed Critical Delalande Sa
Publication of CH611283A5 publication Critical patent/CH611283A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

Compounds corresponding to the formula (I): <IMAGE> in which R represents: - an ethoxycarbonyl group, Ar then representing a phenyl ring, - a p-morpholinocarbonyl group, Ar then representing a phenyl ring substituted in the ortho position by a halogen atom, or - an o- or m-morpholinocarbonyl group, Ar then representing a phenyl ring substituted in the para position by a halogen atom are prepared. For this, 2-aryl-4-chloro-6-methylpyrimidines are condensed with corresponding anilino derivatives in acetic acid and in the presence of hydrochloric acid. The ethoxycarbonyl residue can also be converted to 2-morpholinoethylaminocarbonyl. The new compounds can be used as antianoxics.
CH765677A 1976-07-07 1977-06-22 Process for the preparation of arylaminopyrimidine derivatives CH611283A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7620775A FR2357252A2 (en) 1976-07-07 1976-07-07 (2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.
FR7718471A FR2394543A2 (en) 1977-06-16 1977-06-16 (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine

Publications (1)

Publication Number Publication Date
CH611283A5 true CH611283A5 (en) 1979-05-31

Family

ID=26219529

Family Applications (1)

Application Number Title Priority Date Filing Date
CH765677A CH611283A5 (en) 1976-07-07 1977-06-22 Process for the preparation of arylaminopyrimidine derivatives

Country Status (11)

Country Link
JP (1) JPS5312877A (en)
AU (1) AU2680877A (en)
CH (1) CH611283A5 (en)
DE (1) DE2729360A1 (en)
ES (1) ES460411A2 (en)
GB (1) GB1548858A (en)
IT (1) IT1114810B (en)
LU (1) LU77660A1 (en)
NL (1) NL7707531A (en)
SE (1) SE7707880L (en)
SU (1) SU679143A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047268A2 (en) * 2003-11-10 2005-05-26 X-Ceptor Therapeutics, Inc. Substituted pyrimidine compositions and methods of use

Also Published As

Publication number Publication date
DE2729360A1 (en) 1978-01-12
AU2680877A (en) 1979-01-11
GB1548858A (en) 1979-07-18
ES460411A2 (en) 1978-10-01
NL7707531A (en) 1978-01-10
SE7707880L (en) 1978-01-08
IT1114810B (en) 1986-01-27
SU679143A3 (en) 1979-08-05
JPS5312877A (en) 1978-02-04
LU77660A1 (en) 1978-01-27

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Legal Events

Date Code Title Description
PL Patent ceased