ES446700A1 - Biphenyl derivatives and pharmaceutical compositions thereof - Google Patents
Biphenyl derivatives and pharmaceutical compositions thereofInfo
- Publication number
- ES446700A1 ES446700A1 ES446700A ES446700A ES446700A1 ES 446700 A1 ES446700 A1 ES 446700A1 ES 446700 A ES446700 A ES 446700A ES 446700 A ES446700 A ES 446700A ES 446700 A1 ES446700 A1 ES 446700A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- group
- hydroxy group
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 229910052740 iodine Inorganic materials 0.000 abstract 4
- 238000002360 preparation method Methods 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new biphenyl derivatives of the general formula I, ** (See formula) ** wherein the radical represents a chlorine or fluorine atom and B represents the hydroxy group, an alkoxy or aralkoxy group or the amino group and, if B means the hydroxy group, of its salts with organic and inorganic bases, characterized because for the preparation of compounds of the general formula I, in which B represents a hydroxy group, an alkoxy or aralkoxy group, a compound of the general formula II is reacted, ** (See formula) ** where R1 is as defined above and Hal means a halogen atom, with a compound of the general formula, ** (See formula) ** wherein the radical means an alcoholic or aralcohyl group, first to form a compound of the general formula ** (See formula) ** wherein R1 and R2 have the meanings indicated above, by heating in an anhydrous inert solvent, and then the resulting compound of the general formula III is heated with a strong base, after acidification a compound of the general formula I is isolated, in that B means the hydroxy group, or is heated with water, forming a compound of the general formula I, in which B has the meaning of an alkoxy or aralkoxy radical, depending on which of these meanings had the radical R7 in the compound of general formula III; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases into their two individual optically active components and, if desired, compounds of the general formula I obtained, in which B means the alkoxy group, are saponified to forming compounds of the general formula I, in which B represents the hydroxy group, and, if desired, compounds of the general formula I obtained in which B is the hydroxy group, are transformed, according to usual methods, into their esters or in their salts by organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B means the amino radical, a compound of the general formula I is reacted, where B represents an alkoxy group or a halogen atom, with ammonia at elevated temperatures. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732341507 DE2341507A1 (en) | 1973-08-16 | 1973-08-16 | NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES446700A1 true ES446700A1 (en) | 1977-06-01 |
Family
ID=5889963
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446698A Expired ES446698A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446692A Expired ES446692A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446694A Expired ES446694A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446695A Expired ES446695A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446693A Expired ES446693A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446689A Expired ES446689A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446690A Expired ES446690A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES76446691A Expired ES446691A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446701A Expired ES446701A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446700A Expired ES446700A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446699A Expired ES446699A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Family Applications Before (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446698A Expired ES446698A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446692A Expired ES446692A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446694A Expired ES446694A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446695A Expired ES446695A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446693A Expired ES446693A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446689A Expired ES446689A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446690A Expired ES446690A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES76446691A Expired ES446691A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446701A Expired ES446701A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446699A Expired ES446699A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5049262A (en) |
| AT (1) | AT331235B (en) |
| AU (1) | AU7243074A (en) |
| BE (1) | BE818952A (en) |
| DD (1) | DD114590A5 (en) |
| DE (1) | DE2341507A1 (en) |
| DK (1) | DK433674A (en) |
| ES (11) | ES446698A1 (en) |
| FI (1) | FI238974A (en) |
| FR (1) | FR2240722B1 (en) |
| GB (1) | GB1445283A (en) |
| HU (1) | HU168875B (en) |
| IL (1) | IL45464A0 (en) |
| NL (1) | NL7410292A (en) |
| NO (1) | NO742802L (en) |
| RO (1) | RO72842A (en) |
| SE (1) | SE7410436L (en) |
| ZA (1) | ZA745257B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0231257A1 (en) * | 1985-07-12 | 1987-08-12 | The Upjohn Company | Chemical compounds comrpising substituted phenylrings |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| EP0979226B1 (en) * | 1997-04-21 | 2005-11-09 | Sumitomo Pharmaceuticals Company, Limited | Isoxazole derivatives |
| US9206143B2 (en) * | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
-
1973
- 1973-08-16 DE DE19732341507 patent/DE2341507A1/en active Pending
-
1974
- 1974-07-12 AT AT577674A patent/AT331235B/en not_active IP Right Cessation
- 1974-07-31 NL NL7410292A patent/NL7410292A/en unknown
- 1974-08-02 NO NO742802A patent/NO742802L/no unknown
- 1974-08-12 FI FI2389/74A patent/FI238974A/fi unknown
- 1974-08-14 RO RO7479779A patent/RO72842A/en unknown
- 1974-08-14 HU HUTO977A patent/HU168875B/hu unknown
- 1974-08-14 FR FR7428295A patent/FR2240722B1/fr not_active Expired
- 1974-08-14 IL IL45464A patent/IL45464A0/en unknown
- 1974-08-14 DK DK433674A patent/DK433674A/da unknown
- 1974-08-15 SE SE7410436A patent/SE7410436L/xx unknown
- 1974-08-15 ZA ZA00745257A patent/ZA745257B/en unknown
- 1974-08-15 GB GB3601374A patent/GB1445283A/en not_active Expired
- 1974-08-15 JP JP49093812A patent/JPS5049262A/ja active Pending
- 1974-08-16 AU AU72430/74A patent/AU7243074A/en not_active Expired
- 1974-08-16 DD DD180557A patent/DD114590A5/xx unknown
- 1974-08-16 BE BE147701A patent/BE818952A/en unknown
-
1976
- 1976-04-03 ES ES446698A patent/ES446698A1/en not_active Expired
- 1976-04-03 ES ES446692A patent/ES446692A1/en not_active Expired
- 1976-04-03 ES ES446694A patent/ES446694A1/en not_active Expired
- 1976-04-03 ES ES446695A patent/ES446695A1/en not_active Expired
- 1976-04-03 ES ES446693A patent/ES446693A1/en not_active Expired
- 1976-04-03 ES ES446689A patent/ES446689A1/en not_active Expired
- 1976-04-03 ES ES446690A patent/ES446690A1/en not_active Expired
- 1976-04-03 ES ES76446691A patent/ES446691A1/en not_active Expired
- 1976-04-03 ES ES446701A patent/ES446701A1/en not_active Expired
- 1976-04-03 ES ES446700A patent/ES446700A1/en not_active Expired
- 1976-04-03 ES ES446699A patent/ES446699A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2341507A1 (en) | 1975-02-27 |
| ES446691A1 (en) | 1977-06-16 |
| FR2240722A1 (en) | 1975-03-14 |
| BE818952A (en) | 1975-02-17 |
| NL7410292A (en) | 1975-02-18 |
| ES446694A1 (en) | 1977-06-16 |
| FR2240722B1 (en) | 1978-07-28 |
| ES446689A1 (en) | 1977-06-16 |
| ES446701A1 (en) | 1977-06-01 |
| ZA745257B (en) | 1976-04-28 |
| ES446692A1 (en) | 1977-06-16 |
| IL45464A0 (en) | 1974-11-29 |
| HU168875B (en) | 1976-07-28 |
| GB1445283A (en) | 1976-08-11 |
| AT331235B (en) | 1976-08-10 |
| DK433674A (en) | 1975-04-28 |
| ES446690A1 (en) | 1977-07-01 |
| ES446698A1 (en) | 1977-06-16 |
| ATA577674A (en) | 1975-11-15 |
| AU7243074A (en) | 1976-02-19 |
| FI238974A (en) | 1975-02-17 |
| ES446693A1 (en) | 1977-06-16 |
| DD114590A5 (en) | 1975-08-12 |
| ES446695A1 (en) | 1977-07-01 |
| RO72842A (en) | 1981-11-04 |
| NO742802L (en) | 1975-03-17 |
| JPS5049262A (en) | 1975-05-01 |
| SE7410436L (en) | 1975-02-17 |
| ES446699A1 (en) | 1977-06-16 |
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