ES432471A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** in which the radical R1 signifies a halogen atom and the radical B signifies the hydroxy group, a tertiary alcohol group, and, if B signifies the hydroxy group, of its salts with organic or inorganic bases, characterized in that for the Preparation of compounds of the general formula I, in which the radical B is a tertiary alcohol group, a halide of the general formula II is reacted **(See formula)** where R1 and Hal are halogen atoms, with a metallized acetic acid tert-alcohol ester of general formula III. Me - CH2 - CO2 - ter.alcohilo (III) where Me means a lithium or sodium atom and ter, alcohol means a tertiary alcohol radical with 4 to 10 carbon atoms and, if a compound of the general formula I is to be obtained, in which radical 3 is the hydroxy group, the product thus obtained is then subjected to pyrolysis at temperatures between 150º and 250º; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases into their two individual optically active components, and if desired, compounds obtained from the general formula I, in which B is the hydroxy group, are transformed according to methods per se customary in their salts by means of organic or inorganic bases. (Machine-translation by Google Translate, not legally binding)