ES440282A1 - Diphenyl-butylpiperidines - Google Patents

Diphenyl-butylpiperidines

Info

Publication number
ES440282A1
ES440282A1 ES440282A ES440282A ES440282A1 ES 440282 A1 ES440282 A1 ES 440282A1 ES 440282 A ES440282 A ES 440282A ES 440282 A ES440282 A ES 440282A ES 440282 A1 ES440282 A1 ES 440282A1
Authority
ES
Spain
Prior art keywords
formula
compound
carbon atoms
see
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440282A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia Animal Health Inc
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Publication of ES440282A1 publication Critical patent/ES440282A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C07D211/50—Aroyl radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of piperidine, of general formula: **(See formula)** where R and R1 are H, alkyl containing 1 to 5 carbon atoms, alkoxy containing 1 to 5 carbon atoms, F, Cl, Br or CF3 and R2 is H or acyl containing 2 to 19 carbon atoms, preferably alkanoyl, such as for example acetyl or stearyl, and their pharmaceutically acceptable addition acid salts, characterized in that, it comprises (A) transforming a compound, of formula: **(See formula)** by bromination, ketalisation or hydrolysis to obtain the compound of the formula (I), or (B) to react a compound of the formula: **(See formula)** with a compound of the formula **(See formula)** and subsequent selective hydrogenation of the double ethylenic bond. (Machine-translation by Google Translate, not legally binding)
ES440282A 1974-08-15 1975-08-14 Diphenyl-butylpiperidines Expired ES440282A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35910/74A GB1514718A (en) 1974-08-15 1974-08-15 Diphenyl-butylpiperidines

Publications (1)

Publication Number Publication Date
ES440282A1 true ES440282A1 (en) 1977-03-16

Family

ID=10382911

Family Applications (1)

Application Number Title Priority Date Filing Date
ES440282A Expired ES440282A1 (en) 1974-08-15 1975-08-14 Diphenyl-butylpiperidines

Country Status (13)

Country Link
JP (2) JPS5143765A (en)
AT (1) AT345836B (en)
BE (1) BE832472A (en)
DE (1) DE2536103A1 (en)
DK (1) DK365975A (en)
ES (1) ES440282A1 (en)
FI (1) FI752287A (en)
FR (1) FR2281760A1 (en)
GB (1) GB1514718A (en)
LU (1) LU73204A1 (en)
NL (1) NL7509679A (en)
NO (1) NO752836L (en)
SE (1) SE423627B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63192751A (en) * 1987-02-06 1988-08-10 Ube Ind Ltd Production of 4-hydroxypiperidine
US7540309B2 (en) 2005-07-11 2009-06-02 Delaware Capital Formation, Inc. Auto-release vacuum device
KR101062513B1 (en) 2006-02-17 2011-09-06 에프. 호프만-라 로슈 아게 Benzoyl-piperidine Derivatives as 5HT2 / D3 Modulators
ES2401663T3 (en) 2006-10-31 2013-04-23 F. Hoffmann-La Roche Ag Dual derivative ether derivatives of the 5-HT2a and D3 receptors

Also Published As

Publication number Publication date
FI752287A (en) 1976-02-16
FR2281760A1 (en) 1976-03-12
NO752836L (en) 1976-02-17
DK365975A (en) 1976-02-16
JPS52156872A (en) 1977-12-27
DE2536103A1 (en) 1976-02-26
SE7509138L (en) 1976-02-16
NL7509679A (en) 1976-02-17
GB1514718A (en) 1978-06-21
FR2281760B1 (en) 1979-09-14
LU73204A1 (en) 1976-03-02
JPS5143765A (en) 1976-04-14
BE832472A (en) 1975-12-01
ATA620975A (en) 1978-02-15
SE423627B (en) 1982-05-17
AT345836B (en) 1978-10-10

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