SE7509138L - DIPHENYLBUTYLPIPERIDINES. - Google Patents

DIPHENYLBUTYLPIPERIDINES.

Info

Publication number
SE7509138L
SE7509138L SE7509138A SE7509138A SE7509138L SE 7509138 L SE7509138 L SE 7509138L SE 7509138 A SE7509138 A SE 7509138A SE 7509138 A SE7509138 A SE 7509138A SE 7509138 L SE7509138 L SE 7509138L
Authority
SE
Sweden
Prior art keywords
formula
compound
compounds
formulae
aug
Prior art date
Application number
SE7509138A
Other languages
Swedish (sv)
Other versions
SE423627B (en
Inventor
A K K Bjork
S E H Hernestam
B E S Kjellberg
Original Assignee
Ferrosan Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan Ab filed Critical Ferrosan Ab
Publication of SE7509138L publication Critical patent/SE7509138L/en
Publication of SE423627B publication Critical patent/SE423627B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C07D211/50—Aroyl radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1514718 Piperidine derivatives FERROSAN AB 15 Aug 1975 [15 Aug 1974] 35910/74 Heading C2C The invention comprises compounds of the formulae and acid addition salts thereof, where R and R 1 are H, C 1 -C 5 alkyl, C 1 -C 5 alkoxy, F, Cl, Br or CF 3 and R 2 is H or C 2 -C 14 acyl. Compounds of Formula IV may be prepared by reacting compounds of the formulae where Y is halogen or another reactive radical or by converting a compound of the formula or an ester thereof into the acid chloride and performing a Friedal-Crafts reaction with AlCl 3 and the appropriate benzene derivative. Compounds of Formula I may be prepared by (i) brominating a compound of Formula IV to introduce bromine in the 4-position on the piperidine ring, debrominating the product, e.g. with sodium methoxide in methanol to form a compound of the formula and hydrolysing, to form a compound of Formula I where R 2 is H, and subsequently acylating if desired, (ii) reacting a compound of the formula where X is OR 2 , either with a compound of Formula III to form a compound of Formula I or with a compound of the formula and selectively reducing the olefinic bond in the product to form a compound of Formula I. The compounds of Formula I and their salts have tranquilizing properties and may be used in the treatment of mental disturbances.
SE7509138A 1974-08-15 1975-08-14 PROCEDURE FOR THE PREPARATION OF DIPHENYL BUTYL PIPERIDINES SE423627B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35910/74A GB1514718A (en) 1974-08-15 1974-08-15 Diphenyl-butylpiperidines

Publications (2)

Publication Number Publication Date
SE7509138L true SE7509138L (en) 1976-02-16
SE423627B SE423627B (en) 1982-05-17

Family

ID=10382911

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7509138A SE423627B (en) 1974-08-15 1975-08-14 PROCEDURE FOR THE PREPARATION OF DIPHENYL BUTYL PIPERIDINES

Country Status (13)

Country Link
JP (2) JPS5143765A (en)
AT (1) AT345836B (en)
BE (1) BE832472A (en)
DE (1) DE2536103A1 (en)
DK (1) DK365975A (en)
ES (1) ES440282A1 (en)
FI (1) FI752287A (en)
FR (1) FR2281760A1 (en)
GB (1) GB1514718A (en)
LU (1) LU73204A1 (en)
NL (1) NL7509679A (en)
NO (1) NO752836L (en)
SE (1) SE423627B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63192751A (en) * 1987-02-06 1988-08-10 Ube Ind Ltd Production of 4-hydroxypiperidine
US7540309B2 (en) 2005-07-11 2009-06-02 Delaware Capital Formation, Inc. Auto-release vacuum device
CA2640807A1 (en) 2006-02-17 2007-08-23 F. Hoffmann-La Roche Ag Benzoyl-piperidine derivatives as 5ht2/d3 modulators
JP5087631B2 (en) 2006-10-31 2012-12-05 エフ．ホフマン−ラ ロシュ アーゲー 5-HT2A and D3 receptor dual modulator ether derivatives

Also Published As

Publication number Publication date
FR2281760B1 (en) 1979-09-14
DE2536103A1 (en) 1976-02-26
AT345836B (en) 1978-10-10
JPS5143765A (en) 1976-04-14
ATA620975A (en) 1978-02-15
NL7509679A (en) 1976-02-17
BE832472A (en) 1975-12-01
FI752287A (en) 1976-02-16
FR2281760A1 (en) 1976-03-12
SE423627B (en) 1982-05-17
JPS52156872A (en) 1977-12-27
LU73204A1 (en) 1976-03-02
NO752836L (en) 1976-02-17
GB1514718A (en) 1978-06-21
DK365975A (en) 1976-02-16
ES440282A1 (en) 1977-03-16

Similar Documents

Publication Publication Date Title
GB1506914A (en) 2-dihalophenylamino-2-imidazoline derivatives
GB1176093A (en) Improvements in or relating to Phenyl Arylacylpiperidinols
ES417333A1 (en) Omega-(4'-(3"-indolyl)-piperidino)-alkyl-arylketones
SE7610038L (en) MITICIDA AND AFICIDA CARBOXYLIC ACID ESTERS
ES450740A1 (en) Vincamine derivatives
SE7509138L (en) DIPHENYLBUTYLPIPERIDINES.
CH610582A5 (en) Process for the preparation of a stilbene derivative having analgesic and anti-inflammatory properties
GB1492717A (en) Process for preparing a methyl-isoxazolyl compound
GB1481161A (en) 5-(substituted-benzoyloxy)pyrazoles and a process for their conversion to 4-benzoyl-pyrazole derivatives
IL75741A (en) Monobasic alpha,alpha-disubstituted phenylacetic acid derivatives and their production
GB1041524A (en) Phenyl-indandiones
GB1266456A (en)
GB1177137A (en) Disubstituted Benzyl Methyl-Sulfoxides and -Sulfones
GB1352089A (en) Bis-styryltriazoles their use for the optical brightening of organic materials and processes for their manufacture
ES434922A1 (en) 2-halo-indan-1,3-diones and their use in preparing 2-nitro-indan-1,3 diones
ES377921A1 (en) Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them
GB1492865A (en) Benzopyrano-benzopyran derivatives
ES2032040T3 (en) NEW DERIVATIVES OF NONATRIENE-1,3,5, ITS PREPARATION AND ITS USE.
GB1245916A (en) New thiazoline compounds and methods for their production
GB1152875A (en) Coumarin Derivatives and their use as Optical Whitening Agents
GB1050198A (en)
ES345830A1 (en) Improvements in or relating to Substituted Phenyl Acetic Acids
ES378759A1 (en) Procedure for the preparation of new derivatives of isoquinolein. (Machine-translation by Google Translate, not legally binding)
ES389369A1 (en) Procedure for the production of piperidil - replaced furanones. (Machine-translation by Google Translate, not legally binding)
ES423064A1 (en) A method of preparation of compounds of 1- (7'-alcoxy-3 ', 7'-dimethyloccananoxy) benzene-4-substituted. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7509138-9

Effective date: 19900703

Format of ref document f/p: F