ES377921A1 - Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them - Google Patents

Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them

Info

Publication number
ES377921A1
ES377921A1 ES377921A ES377921A ES377921A1 ES 377921 A1 ES377921 A1 ES 377921A1 ES 377921 A ES377921 A ES 377921A ES 377921 A ES377921 A ES 377921A ES 377921 A1 ES377921 A1 ES 377921A1
Authority
ES
Spain
Prior art keywords
formula
lower alkyl
hydrogen
adamantylcarboxamidophenylacetic
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES377921A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES377921A1 publication Critical patent/ES377921A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Abstract

Procedure for the preparation of derivatives of adamantylcarboxamidophenylacetic acid of formula I **(See formula)** in which one of the symbols R1 and R2 means hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkyl, or lower alkoxy and the other signifies hydrogen, or R1 and R2 mean lower alkoxy, R3 means hydrogen or lower alkyl and R4 signifies hydrogen or lower alkyl, characterized in that a compound of formula II is reacted, **(See formula)** in which R1, R2, R3 and R4 have the significance indicated under formula I, with an acylating agent of formula III **(See formula)** in which X signifies an anionic starting group, preferably a chlorine or bromine atom, and the isolated product, optionally a product of the ester class of formula I, in which R4 represents lower alkyl, hydrolyzes to form the corresponding carboxylic acid, or a carboxylic acid of formula I, in which R4 represents hydrogen it is transformed into the corresponding lower alkyl ester. (Machine-translation by Google Translate, not legally binding)
ES377921A 1969-03-26 1970-03-25 Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them Expired ES377921A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81082869A 1969-03-26 1969-03-26

Publications (1)

Publication Number Publication Date
ES377921A1 true ES377921A1 (en) 1972-10-16

Family

ID=25204813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES377921A Expired ES377921A1 (en) 1969-03-26 1970-03-25 Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them

Country Status (17)

Country Link
JP (1) JPS4826004B1 (en)
AT (1) AT293369B (en)
BE (1) BE747948A (en)
BG (1) BG17524A3 (en)
BR (1) BR7017762D0 (en)
CH (1) CH529107A (en)
DE (1) DE2014506A1 (en)
DK (1) DK124024B (en)
ES (1) ES377921A1 (en)
FR (1) FR2035904B1 (en)
GB (1) GB1310606A (en)
IE (1) IE33762B1 (en)
IL (1) IL34158A (en)
NL (1) NL7003946A (en)
NO (1) NO129346B (en)
PL (1) PL87285B1 (en)
SE (1) SE365507B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60152331U (en) * 1984-03-14 1985-10-09 レンゴ−株式会社 desk
JPS6131224U (en) * 1984-07-31 1986-02-25 株式会社 ムラタインテリアデザイン table

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113227A (en) * 1965-06-24 1968-05-08 Searle & Co Adamantanecarboxylic acid derivatives

Also Published As

Publication number Publication date
BG17524A3 (en) 1973-11-10
IE33762B1 (en) 1974-10-16
GB1310606A (en) 1973-03-21
FR2035904B1 (en) 1974-01-11
DK124024B (en) 1972-09-04
AT293369B (en) 1971-10-11
CH529107A (en) 1972-10-15
IL34158A (en) 1974-01-14
IL34158A0 (en) 1970-05-21
BE747948A (en) 1970-09-25
BR7017762D0 (en) 1973-02-13
PL87285B1 (en) 1976-06-30
SE365507B (en) 1974-03-25
FR2035904A1 (en) 1970-12-24
DE2014506A1 (en) 1970-10-01
NL7003946A (en) 1970-09-29
IE33762L (en) 1970-09-26
JPS4826004B1 (en) 1973-08-03
NO129346B (en) 1974-04-01

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