ES432468A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** wherein radical R1 signifies a halogen atom and radical B signifies the hydroxy group, an alkoxy or aralkoxy group or a group of the formula (see formula), in which R3 and R4, which may be the same or different from each other, represent hydrogen atoms, the carboxymethyl radical, a lower alcohol radical or a phenyl radical optionally substituted by a hydroxy or methyl group, and, in the case of that B means the hydroxy group, of its salts with organic or inorganic bases, characterized in that for the preparation of compounds of the general formula I, in which B means the hydroxy group, carbinols of the general formula are oxidized **(See formula)** in that the radical is as above defined; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases in their two optically active individual components, and if desired, compounds obtained of the general formula I, in which B means the alkoxy group, and in case desired, desired compounds obtained of the general formula I, in which B is the hydroxy group, are transformed according to the usual methods into their esters or salts by means of organic or inorganic bases, or, if desired, for the preparation of compounds of the general formula I, in which B means the radical (see formula), a compound of the general formula I, in which B represents an alkoxy group or a halogen atom, is reacted with a primary or secondary amine at elevated temperatures. (Machine-translation by Google Translate, not legally binding)