ES417792A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** wherein the radical R1 signifies a halogen atom and the radical B signifies the hydroxy group, an alkoxy or aralkoxy group or a group of the formula (see formula), in which R3 and R4, which may be the same or different from each other, represent hydrogen atoms, the carboxymethyl radical, a lower alcohol radical or a phenyl radical optionally substituted by a hydroxy or methyl group, and, in the case of that B means the hydroxy group, of its salts with organic or inorganic bases, characterized in that for the preparation of compounds of the general formula I, in which B means the hydroxy group, a compound of the general formula II is reacted **(See formula)** where R1 is as initially defined and X means the hydroxy group, a halogen atom or any acyloxy radical, with a 1,1-dihalogenoethylene in sulfuric acid, and the intermediate is hydrolyzed by the addition of water; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases in their two optically active individual components, and if desired, compounds obtained of the general formula I, in which B is the hydroxy group, are transformed according to methods per se customary in their esters or in their salts by means of organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B means the radical (see formula), a compound of the general formula I, in which B represents an alkoxy group or a halogen atom, is reacted with a primary or secondary amine at elevated temperatures. (Machine-translation by Google Translate, not legally binding)