ES432469A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** wherein the radical signifies a halogen atom and the radical B signifies the hydroxy group, an alkoxy or aralkoxy group or a group of the formula (see formula) in which R3 and R4, which may be the same or different from each other, represent hydrogen atoms, the carboxymethyl radical, a lower alcohol radical or a phenyl radical optionally substituted by a hydroxy or methyl group, and, if B stands for the hydroxy group of its salts with organic or inorganic bases, characterized in that for the preparation of compounds of the general formula I, in which B stands for the hydroxy group, a compound of Grignard of the general formula II, **(See formula)** where the radical R1 is as defined above and the radical Hal signifies a halogen atom; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases into their two individual optically active components, and if desired, compounds obtained from the general formula I, in which B is the hydroxy group, are transformed according to methods per se usual in their esters or in their salts by means of organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B means the radical (see formula), a compound of the general formula I, in which B represents an alkoxy group or halogen atoms, is reacted with a primary or secondary amine at elevated temperatures. (Machine-translation by Google Translate, not legally binding)