ES402483A1 - Substituted tetrahydroquinolines - Google Patents
Substituted tetrahydroquinolinesInfo
- Publication number
- ES402483A1 ES402483A1 ES402483A ES402483A ES402483A1 ES 402483 A1 ES402483 A1 ES 402483A1 ES 402483 A ES402483 A ES 402483A ES 402483 A ES402483 A ES 402483A ES 402483 A1 ES402483 A1 ES 402483A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- group
- alkanoyloxy
- methyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for obtaining the dextro-rotary form of substituted tetrahydroquinolines, of formula: **(See formula)** wherein R1 and R2 each represent hydrogen or a lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, alkanoyloxy-lower alkyl or lower cycloalkyl group, or together with the nitrogen atom to which they are attached, form a saturated heterocyclic group which may be further substituted by one or more lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or alkanoyloxy-lower alkyl groups; R3, R6 and R7 are each hydrogen or a lower alkyl group; it is a methyl, hydroxymethyl, lower alkoxy methyl, lower alkanoyloxy methyl or formyl group; it is a nitro or cyano or halogen group; and n is 1 or 2, characterized in that it comprises preparing an optically active acid addition salt of the racemic form of the compound, using molar equivalent medium of the appropriate optically active acid anion; separate the salt that crystallizes; recrystallize it from a suitable solvent; and converting it to the free base or a pharmaceutically acceptable acid addition salt of the desired counter-rotational form of the compound. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1345171A GB1366683A (en) | 1971-05-06 | 1971-05-06 | Substituted tetrahydroquinolines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES402483A1 true ES402483A1 (en) | 1975-03-16 |
Family
ID=10023227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES402483A Expired ES402483A1 (en) | 1971-05-06 | 1972-05-06 | Substituted tetrahydroquinolines |
Country Status (8)
Country | Link |
---|---|
AR (1) | AR205874A1 (en) |
AU (1) | AU4164572A (en) |
BE (1) | BE782924A (en) |
CH (1) | CH575396A5 (en) |
DE (1) | DE2221669A1 (en) |
ES (1) | ES402483A1 (en) |
FR (1) | FR2135348B1 (en) |
GB (1) | GB1366683A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9601362A3 (en) * | 1996-05-21 | 1999-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing optically active compounds |
HUP9601361A3 (en) * | 1996-05-21 | 1999-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing optically active compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1278273A (en) * | 1970-01-29 | 1972-06-21 | Pfizer Ltd | Substituted tetrahydroquinolines |
-
1971
- 1971-05-06 GB GB1345171A patent/GB1366683A/en not_active Expired
-
1972
- 1972-01-01 AR AR24180572A patent/AR205874A1/en active
- 1972-04-27 AU AU41645/72A patent/AU4164572A/en not_active Expired
- 1972-05-02 BE BE782924A patent/BE782924A/en not_active IP Right Cessation
- 1972-05-03 DE DE19722221669 patent/DE2221669A1/en not_active Ceased
- 1972-05-04 CH CH665172A patent/CH575396A5/xx not_active IP Right Cessation
- 1972-05-05 FR FR7216235A patent/FR2135348B1/fr not_active Expired
- 1972-05-06 ES ES402483A patent/ES402483A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AR205874A1 (en) | 1976-06-15 |
DE2221669A1 (en) | 1972-12-28 |
AU4164572A (en) | 1973-11-01 |
BE782924A (en) | 1972-11-03 |
CH575396A5 (en) | 1976-05-14 |
FR2135348A1 (en) | 1972-12-15 |
GB1366683A (en) | 1974-09-11 |
FR2135348B1 (en) | 1976-04-16 |
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