ES402483A1 - Substituted tetrahydroquinolines - Google Patents

Substituted tetrahydroquinolines

Info

Publication number
ES402483A1
ES402483A1 ES402483A ES402483A ES402483A1 ES 402483 A1 ES402483 A1 ES 402483A1 ES 402483 A ES402483 A ES 402483A ES 402483 A ES402483 A ES 402483A ES 402483 A1 ES402483 A1 ES 402483A1
Authority
ES
Spain
Prior art keywords
lower alkyl
group
alkanoyloxy
methyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES402483A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES402483A1 publication Critical patent/ES402483A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for obtaining the dextro-rotary form of substituted tetrahydroquinolines, of formula: **(See formula)** wherein R1 and R2 each represent hydrogen or a lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, alkanoyloxy-lower alkyl or lower cycloalkyl group, or together with the nitrogen atom to which they are attached, form a saturated heterocyclic group which may be further substituted by one or more lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or alkanoyloxy-lower alkyl groups; R3, R6 and R7 are each hydrogen or a lower alkyl group; it is a methyl, hydroxymethyl, lower alkoxy methyl, lower alkanoyloxy methyl or formyl group; it is a nitro or cyano or halogen group; and n is 1 or 2, characterized in that it comprises preparing an optically active acid addition salt of the racemic form of the compound, using molar equivalent medium of the appropriate optically active acid anion; separate the salt that crystallizes; recrystallize it from a suitable solvent; and converting it to the free base or a pharmaceutically acceptable acid addition salt of the desired counter-rotational form of the compound. (Machine-translation by Google Translate, not legally binding)
ES402483A 1971-05-06 1972-05-06 Substituted tetrahydroquinolines Expired ES402483A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1345171A GB1366683A (en) 1971-05-06 1971-05-06 Substituted tetrahydroquinolines

Publications (1)

Publication Number Publication Date
ES402483A1 true ES402483A1 (en) 1975-03-16

Family

ID=10023227

Family Applications (1)

Application Number Title Priority Date Filing Date
ES402483A Expired ES402483A1 (en) 1971-05-06 1972-05-06 Substituted tetrahydroquinolines

Country Status (8)

Country Link
AR (1) AR205874A1 (en)
AU (1) AU4164572A (en)
BE (1) BE782924A (en)
CH (1) CH575396A5 (en)
DE (1) DE2221669A1 (en)
ES (1) ES402483A1 (en)
FR (1) FR2135348B1 (en)
GB (1) GB1366683A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9601361A3 (en) * 1996-05-21 1999-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing optically active compounds
HUP9601362A3 (en) * 1996-05-21 1999-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing optically active compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1278273A (en) * 1970-01-29 1972-06-21 Pfizer Ltd Substituted tetrahydroquinolines

Also Published As

Publication number Publication date
AR205874A1 (en) 1976-06-15
DE2221669A1 (en) 1972-12-28
FR2135348A1 (en) 1972-12-15
FR2135348B1 (en) 1976-04-16
GB1366683A (en) 1974-09-11
BE782924A (en) 1972-11-03
AU4164572A (en) 1973-11-01
CH575396A5 (en) 1976-05-14

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