ES446689A1 - Biphenyl derivatives and pharmaceutical compositions thereof - Google Patents
Biphenyl derivatives and pharmaceutical compositions thereofInfo
- Publication number
- ES446689A1 ES446689A1 ES446689A ES446689A ES446689A1 ES 446689 A1 ES446689 A1 ES 446689A1 ES 446689 A ES446689 A ES 446689A ES 446689 A ES446689 A ES 446689A ES 446689 A1 ES446689 A1 ES 446689A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- group
- hydroxy group
- compounds
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Abstract
Procedure for the preparation of new 3- (4-biphenyl) -butyric acids, their esters or nests of the general formula I, ** (See formula) ** wherein the radical represents a chlorine or fluorine atom and B represents the hydroxy group, an alkoxy or aralkoxy group or the amino group and, if B means the hydroxy group, of its salts with organic and inorganic bases, characterized because for the preparation of a compound of the general formula I, in which B means the hydroxy group or an alkoxy group, a compound of the general formula is reduced, ** (See formula) ** where R1 and B are not as above defined; and the eventually obtained racemates are split by fractional recrystallization of their salts with optically active bases into their two individual optically active components and, if desired, compounds of the general formula I obtained, in which B is the alkoxy group, are saponified to forming compounds of the general formula I, in which B represents the hydroxy group and, if desired, compounds of the general formula I obtained in which B is the hydroxy group, are transformed, in accordance with usual methods, into a their esters or in their salts by organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B is the amino radical, a compound of the general formula is reacted ** (See formula) ** where B represents an alkoxy group or a halogen atom, with ammonia at elevated temperatures. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732341507 DE2341507A1 (en) | 1973-08-16 | 1973-08-16 | NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES446689A1 true ES446689A1 (en) | 1977-06-16 |
Family
ID=5889963
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES76446691A Expired ES446691A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446698A Expired ES446698A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446695A Expired ES446695A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446694A Expired ES446694A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446690A Expired ES446690A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446699A Expired ES446699A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446700A Expired ES446700A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446701A Expired ES446701A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446693A Expired ES446693A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446689A Expired ES446689A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446692A Expired ES446692A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Family Applications Before (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES76446691A Expired ES446691A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446698A Expired ES446698A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446695A Expired ES446695A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446694A Expired ES446694A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446690A Expired ES446690A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446699A Expired ES446699A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446700A Expired ES446700A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446701A Expired ES446701A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
| ES446693A Expired ES446693A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446692A Expired ES446692A1 (en) | 1973-08-16 | 1976-04-03 | Biphenyl derivatives and pharmaceutical compositions thereof |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5049262A (en) |
| AT (1) | AT331235B (en) |
| AU (1) | AU7243074A (en) |
| BE (1) | BE818952A (en) |
| DD (1) | DD114590A5 (en) |
| DE (1) | DE2341507A1 (en) |
| DK (1) | DK433674A (en) |
| ES (11) | ES446691A1 (en) |
| FI (1) | FI238974A (en) |
| FR (1) | FR2240722B1 (en) |
| GB (1) | GB1445283A (en) |
| HU (1) | HU168875B (en) |
| IL (1) | IL45464A0 (en) |
| NL (1) | NL7410292A (en) |
| NO (1) | NO742802L (en) |
| RO (1) | RO72842A (en) |
| SE (1) | SE7410436L (en) |
| ZA (1) | ZA745257B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63500241A (en) * | 1985-07-12 | 1988-01-28 | ジ・アップジョン・カンパニ− | flurbiprofen manufacturing method |
| ES2248894T3 (en) * | 1997-04-21 | 2006-03-16 | Dainippon Sumitomo Pharma Co., Ltd. | ISOXAZOL DERIVATIVES |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| CA2718723C (en) * | 2008-03-19 | 2018-05-08 | Aurimmed Pharma, Inc. | Novel compounds advantageous in the treatment of central nervous system diseases and disorders |
-
1973
- 1973-08-16 DE DE19732341507 patent/DE2341507A1/en active Pending
-
1974
- 1974-07-12 AT AT577674A patent/AT331235B/en not_active IP Right Cessation
- 1974-07-31 NL NL7410292A patent/NL7410292A/en unknown
- 1974-08-02 NO NO742802A patent/NO742802L/no unknown
- 1974-08-12 FI FI2389/74A patent/FI238974A/fi unknown
- 1974-08-14 IL IL45464A patent/IL45464A0/en unknown
- 1974-08-14 HU HUTO977A patent/HU168875B/hu unknown
- 1974-08-14 DK DK433674A patent/DK433674A/da unknown
- 1974-08-14 RO RO7479779A patent/RO72842A/en unknown
- 1974-08-14 FR FR7428295A patent/FR2240722B1/fr not_active Expired
- 1974-08-15 SE SE7410436A patent/SE7410436L/xx unknown
- 1974-08-15 ZA ZA00745257A patent/ZA745257B/en unknown
- 1974-08-15 GB GB3601374A patent/GB1445283A/en not_active Expired
- 1974-08-15 JP JP49093812A patent/JPS5049262A/ja active Pending
- 1974-08-16 BE BE147701A patent/BE818952A/en unknown
- 1974-08-16 AU AU72430/74A patent/AU7243074A/en not_active Expired
- 1974-08-16 DD DD180557A patent/DD114590A5/xx unknown
-
1976
- 1976-04-03 ES ES76446691A patent/ES446691A1/en not_active Expired
- 1976-04-03 ES ES446698A patent/ES446698A1/en not_active Expired
- 1976-04-03 ES ES446695A patent/ES446695A1/en not_active Expired
- 1976-04-03 ES ES446694A patent/ES446694A1/en not_active Expired
- 1976-04-03 ES ES446690A patent/ES446690A1/en not_active Expired
- 1976-04-03 ES ES446699A patent/ES446699A1/en not_active Expired
- 1976-04-03 ES ES446700A patent/ES446700A1/en not_active Expired
- 1976-04-03 ES ES446701A patent/ES446701A1/en not_active Expired
- 1976-04-03 ES ES446693A patent/ES446693A1/en not_active Expired
- 1976-04-03 ES ES446689A patent/ES446689A1/en not_active Expired
- 1976-04-03 ES ES446692A patent/ES446692A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DD114590A5 (en) | 1975-08-12 |
| SE7410436L (en) | 1975-02-17 |
| JPS5049262A (en) | 1975-05-01 |
| ES446694A1 (en) | 1977-06-16 |
| DK433674A (en) | 1975-04-28 |
| ES446700A1 (en) | 1977-06-01 |
| ES446690A1 (en) | 1977-07-01 |
| ES446701A1 (en) | 1977-06-01 |
| AU7243074A (en) | 1976-02-19 |
| HU168875B (en) | 1976-07-28 |
| NL7410292A (en) | 1975-02-18 |
| AT331235B (en) | 1976-08-10 |
| ES446691A1 (en) | 1977-06-16 |
| RO72842A (en) | 1981-11-04 |
| IL45464A0 (en) | 1974-11-29 |
| ES446695A1 (en) | 1977-07-01 |
| ATA577674A (en) | 1975-11-15 |
| DE2341507A1 (en) | 1975-02-27 |
| ES446699A1 (en) | 1977-06-16 |
| NO742802L (en) | 1975-03-17 |
| ES446698A1 (en) | 1977-06-16 |
| FI238974A (en) | 1975-02-17 |
| ZA745257B (en) | 1976-04-28 |
| FR2240722A1 (en) | 1975-03-14 |
| ES446693A1 (en) | 1977-06-16 |
| BE818952A (en) | 1975-02-17 |
| GB1445283A (en) | 1976-08-11 |
| FR2240722B1 (en) | 1978-07-28 |
| ES446692A1 (en) | 1977-06-16 |
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