GB1445283A - Biphenyl derivatives and pharmaceutical compositions thereof - Google Patents
Biphenyl derivatives and pharmaceutical compositions thereofInfo
- Publication number
- GB1445283A GB1445283A GB3601374A GB3601374A GB1445283A GB 1445283 A GB1445283 A GB 1445283A GB 3601374 A GB3601374 A GB 3601374A GB 3601374 A GB3601374 A GB 3601374A GB 1445283 A GB1445283 A GB 1445283A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- biphenylyl
- bromo
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Abstract
1445283 Diphenyl derivatives DR KARL THOMAE GmbH 15 Aug 1974 [16 Aug 1973] 36013/74 Headings C2C and C2P The invention comprises compounds of the general Formula I wherein R 1 represents a chlorine or fluorine atom and B represents a hydroxyl group, an alkoxy or aralkoxy group or an amino group and basic salts of those compounds of Formula I wherein B represents a hydroxyl group. The compounds of Formula I are used as pharmaceuticals. Many methods for the preparation of compounds of Formula I are described. Examples 16(a) and 17(a) describe respectively the preparation of 2 - (2 - fluoro [and 2 - chloro] - 4 - biphenyl) - 1 - ethoxycarbonyl - 1 - propylidene triphenyl - phosphorane by refluxing in absolute ethyl acetate ethoxycarbonyl-methylidene triphenyl phosphorane with bromo - 1- (2 - fluoro - 4 - biphenylyl)ethane and 1 - (2- chloro - 4 - biphenylyl) - 1 - bromo - ethane respectively.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732341507 DE2341507A1 (en) | 1973-08-16 | 1973-08-16 | NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1445283A true GB1445283A (en) | 1976-08-11 |
Family
ID=5889963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3601374A Expired GB1445283A (en) | 1973-08-16 | 1974-08-15 | Biphenyl derivatives and pharmaceutical compositions thereof |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5049262A (en) |
| AT (1) | AT331235B (en) |
| AU (1) | AU7243074A (en) |
| BE (1) | BE818952A (en) |
| DD (1) | DD114590A5 (en) |
| DE (1) | DE2341507A1 (en) |
| DK (1) | DK433674A (en) |
| ES (11) | ES446694A1 (en) |
| FI (1) | FI238974A (en) |
| FR (1) | FR2240722B1 (en) |
| GB (1) | GB1445283A (en) |
| HU (1) | HU168875B (en) |
| IL (1) | IL45464A0 (en) |
| NL (1) | NL7410292A (en) |
| NO (1) | NO742802L (en) |
| RO (1) | RO72842A (en) |
| SE (1) | SE7410436L (en) |
| ZA (1) | ZA745257B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
| US9206143B2 (en) | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| CN1138764C (en) * | 1997-04-21 | 2004-02-18 | 住友制药株式会社 | Isoxazole derivatives |
-
1973
- 1973-08-16 DE DE19732341507 patent/DE2341507A1/en active Pending
-
1974
- 1974-07-12 AT AT577674A patent/AT331235B/en not_active IP Right Cessation
- 1974-07-31 NL NL7410292A patent/NL7410292A/en unknown
- 1974-08-02 NO NO742802A patent/NO742802L/no unknown
- 1974-08-12 FI FI2389/74A patent/FI238974A/fi unknown
- 1974-08-14 FR FR7428295A patent/FR2240722B1/fr not_active Expired
- 1974-08-14 DK DK433674A patent/DK433674A/da unknown
- 1974-08-14 HU HUTO977A patent/HU168875B/hu unknown
- 1974-08-14 IL IL45464A patent/IL45464A0/en unknown
- 1974-08-14 RO RO7479779A patent/RO72842A/en unknown
- 1974-08-15 ZA ZA00745257A patent/ZA745257B/en unknown
- 1974-08-15 GB GB3601374A patent/GB1445283A/en not_active Expired
- 1974-08-15 JP JP49093812A patent/JPS5049262A/ja active Pending
- 1974-08-15 SE SE7410436A patent/SE7410436L/xx unknown
- 1974-08-16 AU AU72430/74A patent/AU7243074A/en not_active Expired
- 1974-08-16 DD DD180557A patent/DD114590A5/xx unknown
- 1974-08-16 BE BE147701A patent/BE818952A/en unknown
-
1976
- 1976-04-03 ES ES446694A patent/ES446694A1/en not_active Expired
- 1976-04-03 ES ES446689A patent/ES446689A1/en not_active Expired
- 1976-04-03 ES ES446701A patent/ES446701A1/en not_active Expired
- 1976-04-03 ES ES446693A patent/ES446693A1/en not_active Expired
- 1976-04-03 ES ES446690A patent/ES446690A1/en not_active Expired
- 1976-04-03 ES ES446698A patent/ES446698A1/en not_active Expired
- 1976-04-03 ES ES446692A patent/ES446692A1/en not_active Expired
- 1976-04-03 ES ES446700A patent/ES446700A1/en not_active Expired
- 1976-04-03 ES ES76446691A patent/ES446691A1/en not_active Expired
- 1976-04-03 ES ES446699A patent/ES446699A1/en not_active Expired
- 1976-04-03 ES ES446695A patent/ES446695A1/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885404A (en) * | 1985-07-12 | 1989-12-05 | The Upjohn Company | Flurbiprofen intermediate |
| US9206143B2 (en) | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| BE818952A (en) | 1975-02-17 |
| ES446693A1 (en) | 1977-06-16 |
| ES446701A1 (en) | 1977-06-01 |
| ES446695A1 (en) | 1977-07-01 |
| FR2240722A1 (en) | 1975-03-14 |
| ZA745257B (en) | 1976-04-28 |
| DK433674A (en) | 1975-04-28 |
| ES446700A1 (en) | 1977-06-01 |
| NL7410292A (en) | 1975-02-18 |
| ES446694A1 (en) | 1977-06-16 |
| RO72842A (en) | 1981-11-04 |
| JPS5049262A (en) | 1975-05-01 |
| ES446692A1 (en) | 1977-06-16 |
| ES446690A1 (en) | 1977-07-01 |
| FR2240722B1 (en) | 1978-07-28 |
| DE2341507A1 (en) | 1975-02-27 |
| ES446699A1 (en) | 1977-06-16 |
| SE7410436L (en) | 1975-02-17 |
| NO742802L (en) | 1975-03-17 |
| AT331235B (en) | 1976-08-10 |
| AU7243074A (en) | 1976-02-19 |
| FI238974A (en) | 1975-02-17 |
| DD114590A5 (en) | 1975-08-12 |
| ES446689A1 (en) | 1977-06-16 |
| ATA577674A (en) | 1975-11-15 |
| ES446691A1 (en) | 1977-06-16 |
| ES446698A1 (en) | 1977-06-16 |
| HU168875B (en) | 1976-07-28 |
| IL45464A0 (en) | 1974-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |