FR2394543A2 - (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine - Google Patents

(4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine

Info

Publication number
FR2394543A2
FR2394543A2 FR7718471A FR7718471A FR2394543A2 FR 2394543 A2 FR2394543 A2 FR 2394543A2 FR 7718471 A FR7718471 A FR 7718471A FR 7718471 A FR7718471 A FR 7718471A FR 2394543 A2 FR2394543 A2 FR 2394543A2
Authority
FR
France
Prior art keywords
vincamine
phenyl
pyrimidines
phenylamino
protection against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7718471A
Other languages
French (fr)
Inventor
Claude Fauran
Guy Bourgery
Guy Raynaud
Claude Gouret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7718471A priority Critical patent/FR2394543A2/en
Priority to GB25894/77A priority patent/GB1548858A/en
Priority to CH765677A priority patent/CH611283A5/en
Priority to GR53766A priority patent/GR60840B7/en
Priority to IT25031/77A priority patent/IT1114810B/en
Priority to DE19772729360 priority patent/DE2729360A1/en
Priority to LU77660A priority patent/LU77660A1/xx
Priority to ES460411A priority patent/ES460411A2/en
Priority to SU772499407A priority patent/SU679143A3/en
Priority to NL7707531A priority patent/NL7707531A/en
Priority to JP8090477A priority patent/JPS5312877A/en
Priority to SE7707880A priority patent/SE7707880L/en
Priority to AU26808/77A priority patent/AU2680877A/en
Publication of FR2394543A2 publication Critical patent/FR2394543A2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pyrimidine derivs. of formula (I) and their intermediates (I:R is p-CO2Et) (where R1 is CH3 in which case R is COM, and Ar is phenyl opt. substd. by one halo or by 3 1-3C alkoxy at 3,4 and 5 posns.; or R1 is H, in which case R is O p-COM and Ar is o-halophenyl; or R is o- or m-COM and Ar is p-halophenyl; M is morpholino) are new. (I) protect against anoxia with an effectiveness comparable to vincamine but cause no deaths in mice when given orally at 1g/kg (c.f. 50% for vincamine). they are administered e.g. as 50-500 mg capsules 2-6 times/day or parenterally as 50-500 mg ampoules 1-3 times/day. In an example, reaction of (I: R is -p-CO2Et) with 2-morpholinoethylamine gave 4-(p-(2-morpholinoethyl)amino -carbonylanilino)-6-methyl-2-phenylpyrimidine.
FR7718471A 1974-09-20 1977-06-16 (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine Pending FR2394543A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR7718471A FR2394543A2 (en) 1977-06-16 1977-06-16 (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine
GB25894/77A GB1548858A (en) 1976-07-07 1977-06-21 Arylaminopyrimidine derivatives their method of preparation and their application in therapeutics
CH765677A CH611283A5 (en) 1976-07-07 1977-06-22 Process for the preparation of arylaminopyrimidine derivatives
GR53766A GR60840B7 (en) 1974-09-20 1977-06-22 Preparation process of novel arylaminopyrimidin derivatives
IT25031/77A IT1114810B (en) 1976-07-07 1977-06-24 ARYLAMINOPYRIMIDINAL DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
DE19772729360 DE2729360A1 (en) 1976-07-07 1977-06-29 ARYLAMINOPYRIMIDE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
LU77660A LU77660A1 (en) 1976-07-07 1977-06-30
ES460411A ES460411A2 (en) 1976-07-07 1977-07-05 Arylaminopyrimidine derivatives their method of preparation and their application in therapeutics
SU772499407A SU679143A3 (en) 1976-07-07 1977-07-06 Method of producing arylaminopyrimidine derivatives
NL7707531A NL7707531A (en) 1976-07-07 1977-07-06 PROCEDURE FOR THE PREPARATION OF A MEDICINAL PRODUCT, AS WELL AS FOR THE PREPARATION OF NEW ARYLAMINOPYRIMIDINE COMPOUNDS.
JP8090477A JPS5312877A (en) 1976-07-07 1977-07-06 Production of aryaminopiridine derivatives
SE7707880A SE7707880L (en) 1976-07-07 1977-07-06 NEW ARYLAMINOPYRIMIDE INDIVIDUALS AND WAYS TO PREPARE THE SAME
AU26808/77A AU2680877A (en) 1976-07-07 1977-07-06 Arylaminopyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7718471A FR2394543A2 (en) 1977-06-16 1977-06-16 (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine

Publications (1)

Publication Number Publication Date
FR2394543A2 true FR2394543A2 (en) 1979-01-12

Family

ID=9192167

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7718471A Pending FR2394543A2 (en) 1974-09-20 1977-06-16 (4)-Phenylamino-(2)-phenyl-pyrimidines with morpholino substituents - for protection against anoxia and are less toxic than vincamine

Country Status (1)

Country Link
FR (1) FR2394543A2 (en)

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