GB1556877A - Imidazothiazoles and thiazolopyrimidines - Google Patents

Imidazothiazoles and thiazolopyrimidines

Info

Publication number
GB1556877A
GB1556877A GB1940/77A GB194077A GB1556877A GB 1556877 A GB1556877 A GB 1556877A GB 1940/77 A GB1940/77 A GB 1940/77A GB 194077 A GB194077 A GB 194077A GB 1556877 A GB1556877 A GB 1556877A
Authority
GB
United Kingdom
Prior art keywords
radical
formula
alkyl
thiazolopyrimidines
imidazothiazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1940/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diamond Shamrock Corp
Original Assignee
Diamond Shamrock Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/650,318 external-priority patent/US4041167A/en
Application filed by Diamond Shamrock Corp filed Critical Diamond Shamrock Corp
Publication of GB1556877A publication Critical patent/GB1556877A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds of formula I, in which B is an ethylene radical, R2 is hydrogen or an alkylsulphonyl or N-substituted carbamoyl radical, R3 is an alkyl or phenyl or 2-benzofuranyl radical and R5 and R6 are H or an alkyl radical, or B is a 1', 2'-cyclohexylene radical, R2, R5 and R6 are H and R3 is an alkyl radical, are therapeutically active as antiinflamatories. They are obtained by condensing a 2-mercaptoimidazoline of formula II with an alpha -haloketone of formula <IMAGE> in which X represents a halogen. <IMAGE>
GB1940/77A 1976-01-19 1977-01-18 Imidazothiazoles and thiazolopyrimidines Expired GB1556877A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/650,318 US4041167A (en) 1976-01-19 1976-01-19 Antiinflammatory imidazothiazoles
US05/753,350 US4103016A (en) 1976-01-19 1976-12-22 Antiinflammatory imidazothiazoles and thiazolopyrimidines

Publications (1)

Publication Number Publication Date
GB1556877A true GB1556877A (en) 1979-11-28

Family

ID=27095826

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1940/77A Expired GB1556877A (en) 1976-01-19 1977-01-18 Imidazothiazoles and thiazolopyrimidines
GB3315/78A Expired GB1556878A (en) 1976-01-19 1977-01-18 Imidazothiazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3315/78A Expired GB1556878A (en) 1976-01-19 1977-01-18 Imidazothiazoles

Country Status (9)

Country Link
JP (1) JPS52106893A (en)
AU (1) AU516452B2 (en)
CA (1) CA1095524A (en)
CH (2) CH625249A5 (en)
DE (1) DE2701853A1 (en)
FR (1) FR2338281A1 (en)
GB (2) GB1556877A (en)
IL (2) IL59625A0 (en)
NL (1) NL7700531A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006085118A2 (en) * 2005-02-08 2006-08-17 Prosidion Limited Dihydroimidazothiazole derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169490A (en) * 1981-04-10 1982-10-19 Kumiai Chem Ind Co Ltd 2,3-disubstituted-5,6-dihydro-imidazo(2,1-b)thiazole, its salt and their preparation
NO941135L (en) * 1993-04-01 1994-10-03 Daiichi Seiyaku Co Thiazole pyrimidine derivatives
DE10112197A1 (en) * 2001-03-14 2002-09-19 Gruenenthal Gmbh Medicaments for treating e.g. epilepsy, schizophrenia, neurodegenerative diseases or especially pain, comprising new or known pyrazolo-pyrimidine or thiazolo-pyrimidine compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH79A (en) * 1889-01-09 Adam Sautter Johann Movement for pocket watches with an open barrel, new gear pusher system and simplified movement fastening
CH51A (en) * 1888-12-31 Julius Maggi & Cie Perforated envelope for food and beverages
CH46A (en) * 1889-01-09 Milovanovitsch Koka Kosta R Rapid loading device for rear loading rifles
CH64A (en) * 1889-01-08 Skoda E Maschinenfabrikant Bolt for rapid-fire cannons
CH73A (en) * 1889-01-16 Weigert Dr Louis Consumption Healing Apparatus
CH74A (en) * 1889-01-09 Florian Tentschert Innovations to hoists
CH77A (en) * 1889-01-09 Christian Herren Root cutting machine
CH83A (en) * 1888-11-17 1889-01-10 Fontainemelon Horlogerie Improvements made to the construction of watches of all calibers

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006085118A2 (en) * 2005-02-08 2006-08-17 Prosidion Limited Dihydroimidazothiazole derivatives
WO2006085118A3 (en) * 2005-02-08 2006-10-19 Prosidion Ltd Dihydroimidazothiazole derivatives
EA012374B1 (en) * 2005-02-08 2009-10-30 Прозидион Лимитед Dihydroimidazothiazole derivatives

Also Published As

Publication number Publication date
FR2338281B1 (en) 1979-09-28
AU516452B2 (en) 1981-06-04
JPS52106893A (en) 1977-09-07
CA1095524A (en) 1981-02-10
CH634075A5 (en) 1983-01-14
CH625249A5 (en) 1981-09-15
IL59625A0 (en) 1980-06-30
AU2136277A (en) 1978-07-27
DE2701853A1 (en) 1977-07-21
IL59626A0 (en) 1980-06-30
FR2338281A1 (en) 1977-08-12
GB1556878A (en) 1979-11-28
NL7700531A (en) 1977-07-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee