FR2209552A1 - N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity - Google Patents

N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity

Info

Publication number
FR2209552A1
FR2209552A1 FR7243490A FR7243490A FR2209552A1 FR 2209552 A1 FR2209552 A1 FR 2209552A1 FR 7243490 A FR7243490 A FR 7243490A FR 7243490 A FR7243490 A FR 7243490A FR 2209552 A1 FR2209552 A1 FR 2209552A1
Authority
FR
France
Prior art keywords
reacting
substd
benzyl
alkylenediamine
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7243490A
Other languages
French (fr)
Other versions
FR2209552B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Original Assignee
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Produits Chimiques Ugine Kuhlmann, Ugine Kuhlmann SA filed Critical Produits Chimiques Ugine Kuhlmann
Priority to FR7243490A priority Critical patent/FR2209552A1/en
Priority to LU68943A priority patent/LU68943A1/xx
Priority to DE2360619A priority patent/DE2360619A1/en
Priority to NL7316635A priority patent/NL7316635A/xx
Priority to BE138611A priority patent/BE808328A/en
Priority to ES421297A priority patent/ES421297A1/en
Priority to ZA00739339A priority patent/ZA739339B/en
Publication of FR2209552A1 publication Critical patent/FR2209552A1/en
Application granted granted Critical
Publication of FR2209552B1 publication Critical patent/FR2209552B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel cpds. of formula (I): (where n = 2 or 3; R and R' are 1-4C alkyl or hydroxyalkyl or cycloalkyl or NR R' is a heterocycle opt. contg. another heteroatom and opt. substd. by OH, alkyl, phenyl or phenylalkyl) have spasmolytic, coronary dillatory, antiarrhythmic, local anaesthetic, CNS depressant (sedative), respiratory analeptic and uricosuric activity. They are pref. prepd. by (a) reacting isophorone with HO(CH2)nNH2 hydrogenating the prod., reacting with benzyl chloride, halogenating (e.g. with SOCl2), and reacting with HNRR'; or (b) condensing isophorone with H2N(CH2)nNRR', hydrogenating the prod., and reacting with benzyl chloride.
FR7243490A 1972-12-07 1972-12-07 N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity Granted FR2209552A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR7243490A FR2209552A1 (en) 1972-12-07 1972-12-07 N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity
LU68943A LU68943A1 (en) 1972-12-07 1973-12-05
DE2360619A DE2360619A1 (en) 1972-12-07 1973-12-05 ALKYLENE-DIAMINES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE
NL7316635A NL7316635A (en) 1972-12-07 1973-12-05
BE138611A BE808328A (en) 1972-12-07 1973-12-06 NEW ALKYLENE DIAMINES FOR USE AS MEDICINAL PRODUCTS
ES421297A ES421297A1 (en) 1972-12-07 1973-12-07 A procedure for the preparation of new alkillendiamins. (Machine-translation by Google Translate, not legally binding)
ZA00739339A ZA739339B (en) 1972-12-07 1973-12-07 New alkylene diamines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7243490A FR2209552A1 (en) 1972-12-07 1972-12-07 N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity

Publications (2)

Publication Number Publication Date
FR2209552A1 true FR2209552A1 (en) 1974-07-05
FR2209552B1 FR2209552B1 (en) 1975-11-28

Family

ID=9108319

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7243490A Granted FR2209552A1 (en) 1972-12-07 1972-12-07 N-(Substd cyclohexyl)-N-benzyl-alkylenediamine - with coronary dilatory and spasmolytic activity

Country Status (7)

Country Link
BE (1) BE808328A (en)
DE (1) DE2360619A1 (en)
ES (1) ES421297A1 (en)
FR (1) FR2209552A1 (en)
LU (1) LU68943A1 (en)
NL (1) NL7316635A (en)
ZA (1) ZA739339B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716946C2 (en) * 1977-04-16 1986-05-07 Bayer Ag, 5090 Leverkusen Process for the preparation of monohydroxyalkylated amines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130857A1 (en) * 1970-06-23 1972-02-03 Schmidt Kurt Dipl Chem 3,3,5-trimethylcyclohexylamine derivs - with hypertensive/hypotensive

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130857A1 (en) * 1970-06-23 1972-02-03 Schmidt Kurt Dipl Chem 3,3,5-trimethylcyclohexylamine derivs - with hypertensive/hypotensive

Also Published As

Publication number Publication date
ZA739339B (en) 1975-05-28
LU68943A1 (en) 1974-02-12
BE808328A (en) 1974-06-06
DE2360619A1 (en) 1974-06-12
ES421297A1 (en) 1976-04-16
FR2209552B1 (en) 1975-11-28
NL7316635A (en) 1974-06-11

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Legal Events

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CD Change of name or company name
TP Transmission of property
ST Notification of lapse