FR2253505A2 - Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants - Google Patents

Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants

Info

Publication number
FR2253505A2
FR2253505A2 FR7343940A FR7343940A FR2253505A2 FR 2253505 A2 FR2253505 A2 FR 2253505A2 FR 7343940 A FR7343940 A FR 7343940A FR 7343940 A FR7343940 A FR 7343940A FR 2253505 A2 FR2253505 A2 FR 2253505A2
Authority
FR
France
Prior art keywords
anticonvulsants
pinacoline
derivs
modifiers
ketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7343940A
Other languages
French (fr)
Other versions
FR2253505B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unicler
Original Assignee
Unicler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unicler filed Critical Unicler
Priority to FR7343940A priority Critical patent/FR2253505A2/en
Publication of FR2253505A2 publication Critical patent/FR2253505A2/en
Application granted granted Critical
Publication of FR2253505B2 publication Critical patent/FR2253505B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/233—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C49/235—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel cpds of formula (I) (where one of R1 and R2 is H and the other OH, or together the gps. represent O; R3 is either phenyl) substd. by halogen, hydroxy, methoxy, allyloxy, ethylene-dioxy and/or dialkylamino, or pyridyl, opt. in salt form). Modification of hexobarbital narcosis and as anticonvulsants LD50 values are >0.3 g/kg The cpds may also be used as e.g. hypnotic and tranquillising complements due to their CNS action.
FR7343940A 1973-12-10 1973-12-10 Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants Granted FR2253505A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7343940A FR2253505A2 (en) 1973-12-10 1973-12-10 Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7343940A FR2253505A2 (en) 1973-12-10 1973-12-10 Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants

Publications (2)

Publication Number Publication Date
FR2253505A2 true FR2253505A2 (en) 1975-07-04
FR2253505B2 FR2253505B2 (en) 1977-04-22

Family

ID=9128950

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7343940A Granted FR2253505A2 (en) 1973-12-10 1973-12-10 Alpha ethylenic alcohol and ketone derivs of pinacoline - modifiers of hexobarbital narcosis and anticonvulsants

Country Status (1)

Country Link
FR (1) FR2253505A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2518089A1 (en) * 1981-12-11 1983-06-17 Univablot PYRIDYL-1 PENTANONE-3 OXIMES ETHERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT
EP0144033A2 (en) * 1983-12-01 1985-06-12 Bayer Ag Substituted 5-cycloalkyl-2,2-dimethyl-pentan-3-one
EP0193813A1 (en) * 1985-02-26 1986-09-10 BASF Aktiengesellschaft Pyridine derivatives and fungicides containing them
EP0355350A1 (en) * 1988-07-20 1990-02-28 Bayer Ag Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)-pentan-3-one
US7119234B2 (en) 2004-11-19 2006-10-10 Bayer Cropscience Lp Process for the preparation of 1-(4-chlorophenyl)-4,4-dimethylpent-1-ene-3-one
JP2016537435A (en) * 2013-11-20 2016-12-01 ビオコデ Pharmacological treatment of obsessive-compulsive disorder
JP2016540815A (en) * 2013-12-18 2016-12-28 ビオコデ Benzodioxole derivatives for use in the treatment of attention deficit and / or hyperactivity

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2518089A1 (en) * 1981-12-11 1983-06-17 Univablot PYRIDYL-1 PENTANONE-3 OXIMES ETHERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT
EP0082058A1 (en) * 1981-12-11 1983-06-22 Univablot Ethers of oximes of 1-pyridyl-3-pentanone, process for their preparation and their use as a drug
US4477453A (en) * 1981-12-11 1984-10-16 Univablot Oxime ethers of 1-pyridyl-3-pentanone
EP0144033A2 (en) * 1983-12-01 1985-06-12 Bayer Ag Substituted 5-cycloalkyl-2,2-dimethyl-pentan-3-one
EP0144033A3 (en) * 1983-12-01 1986-02-19 Bayer Ag Substituted 5-cycloalkyl-2,2-dimethyl-pentan-3-one
EP0193813A1 (en) * 1985-02-26 1986-09-10 BASF Aktiengesellschaft Pyridine derivatives and fungicides containing them
EP0355350A1 (en) * 1988-07-20 1990-02-28 Bayer Ag Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)-pentan-3-one
US4956505A (en) * 1988-07-20 1990-09-11 Bayer Aktiengesellschaft Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one
US7119234B2 (en) 2004-11-19 2006-10-10 Bayer Cropscience Lp Process for the preparation of 1-(4-chlorophenyl)-4,4-dimethylpent-1-ene-3-one
JP2016537435A (en) * 2013-11-20 2016-12-01 ビオコデ Pharmacological treatment of obsessive-compulsive disorder
US10696647B2 (en) 2013-11-20 2020-06-30 Biocodex Pharmacological treatment of obsessive-compulsive disorder
JP2016540815A (en) * 2013-12-18 2016-12-28 ビオコデ Benzodioxole derivatives for use in the treatment of attention deficit and / or hyperactivity

Also Published As

Publication number Publication date
FR2253505B2 (en) 1977-04-22

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