ES420643A1 - 13-Sulfa-prostaglandins - Google Patents

13-Sulfa-prostaglandins

Info

Publication number
ES420643A1
ES420643A1 ES420643A ES420643A ES420643A1 ES 420643 A1 ES420643 A1 ES 420643A1 ES 420643 A ES420643 A ES 420643A ES 420643 A ES420643 A ES 420643A ES 420643 A1 ES420643 A1 ES 420643A1
Authority
ES
Spain
Prior art keywords
acyloxy
alkyl
sulfa
prostaglandins
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES420643A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2256537A external-priority patent/DE2256537A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES420643A1 publication Critical patent/ES420643A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

Sulfides of the general formula WHEREIN R1 is H or alkyl, R2 is =O, (H,OH), or (H,lower-acyloxy), R3 is H, OH or lower-acyloxy, R4 is alkyl or alkyl substituted by F, OH, lower-acyloxy, phenyl or p-tolyl, and A is alkylene which can be mono- or polysubstituted by F, and the physiologically acceptable salts thereof, possess, in addition to a blood-pressure-lowering activity, prostaglandin-type and antiprostaglandin-type effects.
ES420643A 1972-11-17 1973-11-17 13-Sulfa-prostaglandins Expired ES420643A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2256537A DE2256537A1 (en) 1972-11-17 1972-11-17 NEW SULPHIDES

Publications (1)

Publication Number Publication Date
ES420643A1 true ES420643A1 (en) 1976-09-01

Family

ID=5862067

Family Applications (1)

Application Number Title Priority Date Filing Date
ES420643A Expired ES420643A1 (en) 1972-11-17 1973-11-17 13-Sulfa-prostaglandins

Country Status (21)

Country Link
US (1) US3932487A (en)
JP (1) JPS5837311B2 (en)
AT (1) AT335418B (en)
AU (1) AU474893B2 (en)
BE (1) BE807385A (en)
BR (1) BR7308744D0 (en)
CA (1) CA1032937A (en)
CH (4) CH590220A5 (en)
CS (1) CS200463B2 (en)
DD (1) DD109216A5 (en)
DK (1) DK145878C (en)
ES (1) ES420643A1 (en)
FR (1) FR2206939B1 (en)
GB (1) GB1404113A (en)
HU (1) HU169233B (en)
IL (1) IL43633A (en)
NL (1) NL7315589A (en)
PL (1) PL90170B1 (en)
SE (2) SE423540B (en)
YU (1) YU296173A (en)
ZA (1) ZA738697B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2422924A1 (en) * 1974-05-11 1975-11-27 Merck Patent Gmbh THIAPROSTAGLANDINE
US4209639A (en) * 1975-09-22 1980-06-24 American Cyanamid Company 13-Thia-prostaglandins
US4131746A (en) * 1976-04-05 1978-12-26 Syntex (Usa) Inc. (DL)-13-Substituted sulfinyl-prostaglandin-like compounds and methods of making
DE2644972C2 (en) * 1976-10-06 1986-06-19 Merck Patent Gmbh, 6100 Darmstadt Thiaprostanoic acid derivatives, their preparation and compositions containing these compounds
US4092349A (en) * 1976-11-10 1978-05-30 Pfizer Inc. 11-Desoxy-15-thiaprostaglandins
US4085272A (en) * 1977-03-30 1978-04-18 American Cyanamid Company 11-(2-Hydroxyethylthio)prostenoic acid E2 series derivatives
US4189597A (en) * 1977-03-30 1980-02-19 American Cyanamid Company 11-(2-Hydroxyethylthio)prostenoic acid E series derivatives
US4218566A (en) * 1977-03-30 1980-08-19 American Cyanamid Company 11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives
DE3401542A1 (en) * 1984-01-18 1985-08-01 Merck Patent Gmbh, 6100 Darmstadt SULFURIZED 6-KETOPROSTAGLANDINE
JPS6244795U (en) * 1985-09-09 1987-03-18
FR2631028B1 (en) * 1988-05-09 1990-07-13 Cird ADAMANTYL-2 ISOTHIAZOLINE-4 ONES-3, THEIR PREPARATION PROCESS AND THEIR USE AS BACTERICIDAL AND FUNGICIDAL AGENTS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776940A (en) * 1966-08-09 1973-12-04 G Just Intermediates for producing prostaglandins
US3749741A (en) * 1968-02-01 1973-07-31 American Home Prod Tetrahydropyranyl-dihydro-pge1

Also Published As

Publication number Publication date
ATA964773A (en) 1976-07-15
CA1032937A (en) 1978-06-13
PL90170B1 (en) 1977-01-31
JPS4981350A (en) 1974-08-06
ZA738697B (en) 1974-09-25
BE807385A (en) 1974-05-16
DK145878C (en) 1983-09-12
IL43633A (en) 1977-01-31
NL7315589A (en) 1974-05-21
GB1404113A (en) 1975-08-28
JPS5837311B2 (en) 1983-08-15
SE423092B (en) 1982-04-13
SE423540B (en) 1982-05-10
DK145878B (en) 1983-03-28
CS200463B2 (en) 1980-09-15
DD109216A5 (en) 1974-10-20
CH613189A5 (en) 1979-09-14
FR2206939B1 (en) 1977-04-15
BR7308744D0 (en) 1974-08-22
IL43633A0 (en) 1974-03-14
FR2206939A1 (en) 1974-06-14
SE7612055L (en) 1976-10-29
HU169233B (en) 1976-10-28
AT335418B (en) 1977-03-10
CH590220A5 (en) 1977-07-29
CH618424A5 (en) 1980-07-31
AU474893B2 (en) 1976-08-05
US3932487A (en) 1976-01-13
CH612933A5 (en) 1979-08-31
YU296173A (en) 1982-06-18
AU6260773A (en) 1975-05-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19850214