FR2155856A1 - N-2 pyridylureas - with antiinflammatory and analgesic activity - Google Patents

N-2 pyridylureas - with antiinflammatory and analgesic activity

Info

Publication number
FR2155856A1
FR2155856A1 FR7136497A FR7136497A FR2155856A1 FR 2155856 A1 FR2155856 A1 FR 2155856A1 FR 7136497 A FR7136497 A FR 7136497A FR 7136497 A FR7136497 A FR 7136497A FR 2155856 A1 FR2155856 A1 FR 2155856A1
Authority
FR
France
Prior art keywords
antiinflammatory
analgesic activity
pyridylureas
cpds
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7136497A
Other languages
French (fr)
Other versions
FR2155856B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LEURQUIN LAB
Original Assignee
LEURQUIN LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEURQUIN LAB filed Critical LEURQUIN LAB
Priority to FR7136497A priority Critical patent/FR2155856A1/en
Publication of FR2155856A1 publication Critical patent/FR2155856A1/en
Application granted granted Critical
Publication of FR2155856B1 publication Critical patent/FR2155856B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Abstract

Cpds of formula: where R is 1-5C alkyl, 5-6C cycloalkyl; phenyl opt. substd. by >=1 halogen, NO2; naphthyl. The cpds. have antiinflammatory and analgesic activity with no ulcerogenic activity on the gastic mucosa. Prepd. from 2-aminopyridine and a suitable isocyanate.
FR7136497A 1971-10-11 1971-10-11 N-2 pyridylureas - with antiinflammatory and analgesic activity Granted FR2155856A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7136497A FR2155856A1 (en) 1971-10-11 1971-10-11 N-2 pyridylureas - with antiinflammatory and analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7136497A FR2155856A1 (en) 1971-10-11 1971-10-11 N-2 pyridylureas - with antiinflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
FR2155856A1 true FR2155856A1 (en) 1973-05-25
FR2155856B1 FR2155856B1 (en) 1974-11-15

Family

ID=9084188

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7136497A Granted FR2155856A1 (en) 1971-10-11 1971-10-11 N-2 pyridylureas - with antiinflammatory and analgesic activity

Country Status (1)

Country Link
FR (1) FR2155856A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135335A2 (en) * 1983-08-22 1985-03-27 Warner-Lambert Company N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas, processes for their production and pharmaceutical compositions comprising the same
US4629731A (en) * 1983-08-22 1986-12-16 Warner-Lambert Company Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas
US4962116A (en) * 1983-08-22 1990-10-09 Warner-Lambert Company N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas
DE19749979A1 (en) * 1997-11-05 1999-05-06 Schering Ag New bis-ureido-diphenylalkane derivative interleukin-4 antagonists
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
EP1619184A2 (en) * 2000-08-15 2006-01-25 Amgen, Inc. Urea compounds as kinase inhibitors
US7196104B2 (en) 2000-08-15 2007-03-27 Amgen, Inc. Thiazolyl urea compounds and methods of uses
WO2015039333A1 (en) * 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135335A2 (en) * 1983-08-22 1985-03-27 Warner-Lambert Company N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas, processes for their production and pharmaceutical compositions comprising the same
US4629731A (en) * 1983-08-22 1986-12-16 Warner-Lambert Company Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas
EP0135335A3 (en) * 1983-08-22 1987-03-11 Warner-Lambert Company N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas, processes for their production and pharmaceutical compositions comprising the same
US4962116A (en) * 1983-08-22 1990-10-09 Warner-Lambert Company N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
DE19749979A1 (en) * 1997-11-05 1999-05-06 Schering Ag New bis-ureido-diphenylalkane derivative interleukin-4 antagonists
DE19749979C2 (en) * 1997-11-05 2000-01-13 Schering Ag Medicaments containing N, N'-substituted ureas and their derivatives
EP1619184A2 (en) * 2000-08-15 2006-01-25 Amgen, Inc. Urea compounds as kinase inhibitors
EP1619184A3 (en) * 2000-08-15 2006-02-01 Amgen, Inc. Urea compounds as kinase inhibitors
US7196104B2 (en) 2000-08-15 2007-03-27 Amgen, Inc. Thiazolyl urea compounds and methods of uses
WO2015039333A1 (en) * 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
US9896447B2 (en) 2013-09-22 2018-02-20 Merck Sharp & Dohme Corp. TrkA kinase inhibitors, compositions and methods thereof

Also Published As

Publication number Publication date
FR2155856B1 (en) 1974-11-15

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