FR2152345A1 - Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity - Google Patents
Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activityInfo
- Publication number
- FR2152345A1 FR2152345A1 FR7132088A FR7132088A FR2152345A1 FR 2152345 A1 FR2152345 A1 FR 2152345A1 FR 7132088 A FR7132088 A FR 7132088A FR 7132088 A FR7132088 A FR 7132088A FR 2152345 A1 FR2152345 A1 FR 2152345A1
- Authority
- FR
- France
- Prior art keywords
- antiinflammatory
- analgesic
- alpha
- thiazolyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Abstract
Cpds. of formula: also their metallic and acid-addition salts and their esters with alkanols (1-4C) R1 = alkyl (1-3C); 2-thienyl opt. substd. by Cl; phenyl opt. substd. by one or two F, Cl, Br or by alkoxy (1-3C), alkylthio (1-3C); R2 = H, alkyl (1-3C), phenyl optionally substituted by F, Cl, Br, alkoxy (1-3C), alkylthio (1-3C), R3 = H, alkyl (1-3C). The cpds. have analgesic, antiinflammatory and antipyretic activity, and are prepd. by reacting the corresp. 2-chlorothiazoles with alpha-hydroxyalkanoic acids.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7132088A FR2152345A1 (en) | 1971-09-06 | 1971-09-06 | Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7132088A FR2152345A1 (en) | 1971-09-06 | 1971-09-06 | Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2152345A1 true FR2152345A1 (en) | 1973-04-27 |
FR2152345B1 FR2152345B1 (en) | 1975-06-06 |
Family
ID=9082542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7132088A Granted FR2152345A1 (en) | 1971-09-06 | 1971-09-06 | Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2152345A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648498A (en) * | 1991-10-30 | 1997-07-15 | Astra Aktiebolag | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof |
WO1999054314A1 (en) * | 1998-04-17 | 1999-10-28 | Boehringer Ingelheim Pharma Kg | Novel diphenyl-substituted 5-ring-heterocycles, method for producing them and their use as medicaments |
WO2013146754A1 (en) * | 2012-03-27 | 2013-10-03 | 塩野義製薬株式会社 | Aromatic heterocyclic five-membered ring derivative having trpv4 inhibitory activity |
-
1971
- 1971-09-06 FR FR7132088A patent/FR2152345A1/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648498A (en) * | 1991-10-30 | 1997-07-15 | Astra Aktiebolag | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof |
WO1999054314A1 (en) * | 1998-04-17 | 1999-10-28 | Boehringer Ingelheim Pharma Kg | Novel diphenyl-substituted 5-ring-heterocycles, method for producing them and their use as medicaments |
WO2013146754A1 (en) * | 2012-03-27 | 2013-10-03 | 塩野義製薬株式会社 | Aromatic heterocyclic five-membered ring derivative having trpv4 inhibitory activity |
JPWO2013146754A1 (en) * | 2012-03-27 | 2015-12-14 | 塩野義製薬株式会社 | Aromatic hetero 5-membered ring derivative having TRPV4 inhibitory activity |
US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
Also Published As
Publication number | Publication date |
---|---|
FR2152345B1 (en) | 1975-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |