FR2112111A2 - Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity - Google Patents

Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity

Info

Publication number
FR2112111A2
FR2112111A2 FR7039647A FR7039647A FR2112111A2 FR 2112111 A2 FR2112111 A2 FR 2112111A2 FR 7039647 A FR7039647 A FR 7039647A FR 7039647 A FR7039647 A FR 7039647A FR 2112111 A2 FR2112111 A2 FR 2112111A2
Authority
FR
France
Prior art keywords
alpha
benzoylthien
antiinflammatory
esters
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7039647A
Other languages
French (fr)
Other versions
FR2112111B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7039647A priority Critical patent/FR2112111A2/en
Publication of FR2112111A2 publication Critical patent/FR2112111A2/en
Application granted granted Critical
Publication of FR2112111B2 publication Critical patent/FR2112111B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Specif. claimed are 9 examples, are the cpds. of gen. formula (I): (where R1 is H or linear or branched 1-4C alkyl; R2 is H or linear or branched alkyl opt. substd. by >=1 OH, beta-dialkylaminoalkyl, N-heterocyclic alkyl gp. or an alkali(ne earth)metal, and Ar is phenyl opt. mono- or poly-substd. by hal, alkyl, CHal3, alkoxy, cyclohexyl or a heterocyclic gp.) described in the parent patent. Two of these examples are dl alpha-methyl 5-(21,41-dichlorobenzoyl)-thiophene 2-acetic acid and dl alpha-methyl 5-(41-methoxybenzoyl)thiophene 2-acetic acid.
FR7039647A 1970-11-04 1970-11-04 Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity Granted FR2112111A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7039647A FR2112111A2 (en) 1970-11-04 1970-11-04 Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7039647A FR2112111A2 (en) 1970-11-04 1970-11-04 Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
FR2112111A2 true FR2112111A2 (en) 1972-06-16
FR2112111B2 FR2112111B2 (en) 1974-08-30

Family

ID=9063723

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7039647A Granted FR2112111A2 (en) 1970-11-04 1970-11-04 Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity

Country Status (1)

Country Link
FR (1) FR2112111A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600065A1 (en) * 1986-06-13 1987-12-18 Roussel Uclaf New derivatives of 5-[(2-benzoyfuranyl)carbonyl]thiopheneacetic acid, their salts, processes for their preparation, their application as medicaments and the pharmaceutical compositions containing them
FR2689128A1 (en) * 1992-03-26 1993-10-01 Roussel Uclaf Prepn. of optically pure tiaprofenic acid - by salt formation with optically active ephedrine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600065A1 (en) * 1986-06-13 1987-12-18 Roussel Uclaf New derivatives of 5-[(2-benzoyfuranyl)carbonyl]thiopheneacetic acid, their salts, processes for their preparation, their application as medicaments and the pharmaceutical compositions containing them
FR2689128A1 (en) * 1992-03-26 1993-10-01 Roussel Uclaf Prepn. of optically pure tiaprofenic acid - by salt formation with optically active ephedrine

Also Published As

Publication number Publication date
FR2112111B2 (en) 1974-08-30

Similar Documents

Publication Publication Date Title
FR2112111A2 (en) Alpha-(5-benzoylthien-2-yl)alkanoic acids and esters - - with antiinflammatory and analgesic activity
ES8607960A1 (en) Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them.
GB1503649A (en) Process for the preparation of alpha-keto acids
IE38821L (en) Thiophene derivatives
ES415406A1 (en) Benzo{8 b{9 thienyl acetic acid esters
FR2220257A1 (en) 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
IE39576B1 (en) Derivatives of 3-(p-chlorobenzoyl)-2-methyl-phenylacetic acid
FR2167334A1 (en) 4-aroyl-5-alkylthiophene-2-acetic acids - with analgesic and antiinflammatory activity
FR2152345A1 (en) Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity
FR2113760A1 (en) 5-Arylcarbonyl-3(or 4)-methylthien-2-yl alkanoic acids and esters - with antiinflammatory and analgesic activity
IE36278L (en) Pyridyl benzofuryl ketones
IE37420B1 (en) Derivatives of penam-3-carboxylic acid and cephem-4-carboxylic acid and processes for their manufacture
ES396447A1 (en) Thiophene carboxylic acid derivatives
FR2241555A1 (en) (Beta aryl) 2-alkyl furan derivs - useful as inters., esp. for benzo(4,5) cyclohepta(1,2-b) furan derivs
ES377996A1 (en) A procedure for the obtaining of new derivatives of the 6-amino-penicilanico acid and its salts. (Machine-translation by Google Translate, not legally binding)
GB1328549A (en) Nitrofuran and nitrothiophene derivatives
BE756615R (en) Diythienl lakyl arylalkyl amines - dithienylalkyl DI THIENYL ALKYL PHARMACEUTICAL
GB1292662A (en) Bicycloheptaneheptanoic acids and esters thereof
FR2077681A1 (en) N-substd azetidin-3-sulphonates-sedatives - and inters for guanidino-azetidines
FR2092719A1 (en) Antiinflammatory pyridazines
ES381429A1 (en) Penicillins
FR2043478A1 (en) Phenethoxy and pyridyl ethoxy ethylamines - with cardioactive and anaesthetic proper-ties
FR2146978A1 (en) 5-phenyl thiazol-2-yl thioacetic acids and derivs - with antiinflammatory, analgesic and antipyretic activity
ES461037A1 (en) Anti-inflammatory thiophene derivatives
FR2081526A1 (en) 4-lower alkyl-cyclohexylamine salts analgesic