FR2158108A1 - 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity - Google Patents

1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity

Info

Publication number
FR2158108A1
FR2158108A1 FR7139376A FR7139376A FR2158108A1 FR 2158108 A1 FR2158108 A1 FR 2158108A1 FR 7139376 A FR7139376 A FR 7139376A FR 7139376 A FR7139376 A FR 7139376A FR 2158108 A1 FR2158108 A1 FR 2158108A1
Authority
FR
France
Prior art keywords
diphenylpropyl
cyano
piperidinols
antitussive
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7139376A
Other languages
French (fr)
Other versions
FR2158108B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7139376A priority Critical patent/FR2158108A1/en
Publication of FR2158108A1 publication Critical patent/FR2158108A1/en
Application granted granted Critical
Publication of FR2158108B1 publication Critical patent/FR2158108B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Cpds. of formula:- and their acid-addn. salts (where R is H, 1-4C alkoxy, Cf3; R1 is H, OH opt. substd. by 2-4C alkanoyl or alkoxycarbonyl) are prepd. by reaction of 3-cyano-3,3-diphenylpropyl halides with the corresp. 4-phenylpiperidine.
FR7139376A 1971-11-03 1971-11-03 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity Granted FR2158108A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7139376A FR2158108A1 (en) 1971-11-03 1971-11-03 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7139376A FR2158108A1 (en) 1971-11-03 1971-11-03 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity

Publications (2)

Publication Number Publication Date
FR2158108A1 true FR2158108A1 (en) 1973-06-15
FR2158108B1 FR2158108B1 (en) 1975-02-07

Family

ID=9085224

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7139376A Granted FR2158108A1 (en) 1971-11-03 1971-11-03 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinols - with analgesic antitussive and spasmolytic activity

Country Status (1)

Country Link
FR (1) FR2158108A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380278A1 (en) * 1977-02-14 1978-09-08 Janssen Pharmaceutica Nv NEWS 1 - ((DIARYLMETHYL) AMINOALKYL) PIPERIDINES
EP0501774A1 (en) * 1991-02-26 1992-09-02 Eli Lilly And Company Preparation of substituted tetrahydropyridines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB895049A (en) * 1959-11-13 1962-04-26 Ernst Boehringer N-substituted-4-aryl-4-acyloxy piperidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB895049A (en) * 1959-11-13 1962-04-26 Ernst Boehringer N-substituted-4-aryl-4-acyloxy piperidines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380278A1 (en) * 1977-02-14 1978-09-08 Janssen Pharmaceutica Nv NEWS 1 - ((DIARYLMETHYL) AMINOALKYL) PIPERIDINES
EP0501774A1 (en) * 1991-02-26 1992-09-02 Eli Lilly And Company Preparation of substituted tetrahydropyridines

Also Published As

Publication number Publication date
FR2158108B1 (en) 1975-02-07

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