FR2276824A1 - Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine - Google Patents
Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeineInfo
- Publication number
- FR2276824A1 FR2276824A1 FR7423262A FR7423262A FR2276824A1 FR 2276824 A1 FR2276824 A1 FR 2276824A1 FR 7423262 A FR7423262 A FR 7423262A FR 7423262 A FR7423262 A FR 7423262A FR 2276824 A1 FR2276824 A1 FR 2276824A1
- Authority
- FR
- France
- Prior art keywords
- propionyl
- codeine
- benzhydryloxymethyl
- piperazines
- good
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1-Propionyl-4-(2-benzhydryloxyethyl)piperazine and its acid-addn. salts, are hew have antitussive activity, without the sedative and respiratory depressant activity of codeine, They are effective against coughs of varied aetiology. They are prepd. by reaction of 1-(2-benzhydryloxyethyl)piperazine with propionyl chloride in chloro-hydrocarbons.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7423262A FR2276824A1 (en) | 1974-07-04 | 1974-07-04 | Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7423262A FR2276824A1 (en) | 1974-07-04 | 1974-07-04 | Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2276824A1 true FR2276824A1 (en) | 1976-01-30 |
FR2276824B1 FR2276824B1 (en) | 1978-07-21 |
Family
ID=9140880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7423262A Granted FR2276824A1 (en) | 1974-07-04 | 1974-07-04 | Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2276824A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601366A1 (en) * | 1986-07-10 | 1988-01-15 | Andre Buzas | BENZHYDRYLOXYETHYL-PIPERAZINE DERIVATIVES, METHODS OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
US4874765A (en) * | 1986-04-22 | 1989-10-17 | Richter Gedeon Vegyeszeti Gyar | 1,4-Disubstituted piperazines having dopaminergic activity |
EP0259227B1 (en) * | 1986-09-05 | 1991-12-27 | Société anonyme: LES LABORATOIRES MERAM | Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions containing them |
WO1992001679A1 (en) * | 1990-07-26 | 1992-02-06 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
-
1974
- 1974-07-04 FR FR7423262A patent/FR2276824A1/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4874765A (en) * | 1986-04-22 | 1989-10-17 | Richter Gedeon Vegyeszeti Gyar | 1,4-Disubstituted piperazines having dopaminergic activity |
AU599100B2 (en) * | 1986-04-28 | 1990-07-12 | Richter Gedeon Vegyeszeti Gyar Rt. | 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same |
FR2601366A1 (en) * | 1986-07-10 | 1988-01-15 | Andre Buzas | BENZHYDRYLOXYETHYL-PIPERAZINE DERIVATIVES, METHODS OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
EP0254627A1 (en) * | 1986-07-10 | 1988-01-27 | Société anonyme: LES LABORATOIRES MERAM | Derivatives of benzhydryloxyethylpiperazine, processes for their preparation and pharmaceutical compositions containing them |
US4908365A (en) * | 1986-07-10 | 1990-03-13 | Andre Buzas | Benzhydryloxyethylpiperazine derivatives, processes for their preparation and pharmaceutical compositions in which they are present |
EP0259227B1 (en) * | 1986-09-05 | 1991-12-27 | Société anonyme: LES LABORATOIRES MERAM | Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions containing them |
WO1992001679A1 (en) * | 1990-07-26 | 1992-02-06 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
AU665172B2 (en) * | 1990-07-26 | 1995-12-21 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
Also Published As
Publication number | Publication date |
---|---|
FR2276824B1 (en) | 1978-07-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |