FR2276824A1 - Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine - Google Patents

Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine

Info

Publication number
FR2276824A1
FR2276824A1 FR7423262A FR7423262A FR2276824A1 FR 2276824 A1 FR2276824 A1 FR 2276824A1 FR 7423262 A FR7423262 A FR 7423262A FR 7423262 A FR7423262 A FR 7423262A FR 2276824 A1 FR2276824 A1 FR 2276824A1
Authority
FR
France
Prior art keywords
propionyl
codeine
benzhydryloxymethyl
piperazines
good
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7423262A
Other languages
French (fr)
Other versions
FR2276824B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7423262A priority Critical patent/FR2276824A1/en
Publication of FR2276824A1 publication Critical patent/FR2276824A1/en
Application granted granted Critical
Publication of FR2276824B1 publication Critical patent/FR2276824B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-Propionyl-4-(2-benzhydryloxyethyl)piperazine and its acid-addn. salts, are hew have antitussive activity, without the sedative and respiratory depressant activity of codeine, They are effective against coughs of varied aetiology. They are prepd. by reaction of 1-(2-benzhydryloxyethyl)piperazine with propionyl chloride in chloro-hydrocarbons.
FR7423262A 1974-07-04 1974-07-04 Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine Granted FR2276824A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7423262A FR2276824A1 (en) 1974-07-04 1974-07-04 Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7423262A FR2276824A1 (en) 1974-07-04 1974-07-04 Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine

Publications (2)

Publication Number Publication Date
FR2276824A1 true FR2276824A1 (en) 1976-01-30
FR2276824B1 FR2276824B1 (en) 1978-07-21

Family

ID=9140880

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7423262A Granted FR2276824A1 (en) 1974-07-04 1974-07-04 Propionyl-benzhydryloxymethyl-piperazines - with antitussive activity as good as that of codeine

Country Status (1)

Country Link
FR (1) FR2276824A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601366A1 (en) * 1986-07-10 1988-01-15 Andre Buzas BENZHYDRYLOXYETHYL-PIPERAZINE DERIVATIVES, METHODS OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
US4874765A (en) * 1986-04-22 1989-10-17 Richter Gedeon Vegyeszeti Gyar 1,4-Disubstituted piperazines having dopaminergic activity
EP0259227B1 (en) * 1986-09-05 1991-12-27 Société anonyme: LES LABORATOIRES MERAM Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions containing them
WO1992001679A1 (en) * 1990-07-26 1992-02-06 Novo Nordisk A/S 1,4-disubstituted piperazines
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874765A (en) * 1986-04-22 1989-10-17 Richter Gedeon Vegyeszeti Gyar 1,4-Disubstituted piperazines having dopaminergic activity
AU599100B2 (en) * 1986-04-28 1990-07-12 Richter Gedeon Vegyeszeti Gyar Rt. 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same
FR2601366A1 (en) * 1986-07-10 1988-01-15 Andre Buzas BENZHYDRYLOXYETHYL-PIPERAZINE DERIVATIVES, METHODS OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
EP0254627A1 (en) * 1986-07-10 1988-01-27 Société anonyme: LES LABORATOIRES MERAM Derivatives of benzhydryloxyethylpiperazine, processes for their preparation and pharmaceutical compositions containing them
US4908365A (en) * 1986-07-10 1990-03-13 Andre Buzas Benzhydryloxyethylpiperazine derivatives, processes for their preparation and pharmaceutical compositions in which they are present
EP0259227B1 (en) * 1986-09-05 1991-12-27 Société anonyme: LES LABORATOIRES MERAM Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions containing them
WO1992001679A1 (en) * 1990-07-26 1992-02-06 Novo Nordisk A/S 1,4-disubstituted piperazines
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
AU665172B2 (en) * 1990-07-26 1995-12-21 Novo Nordisk A/S 1,4-disubstituted piperazines

Also Published As

Publication number Publication date
FR2276824B1 (en) 1978-07-21

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse