PE20091309A1 - Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa - Google Patents

Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa

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Publication number
PE20091309A1
PE20091309A1 PE2008002068A PE2008002068A PE20091309A1 PE 20091309 A1 PE20091309 A1 PE 20091309A1 PE 2008002068 A PE2008002068 A PE 2008002068A PE 2008002068 A PE2008002068 A PE 2008002068A PE 20091309 A1 PE20091309 A1 PE 20091309A1
Authority
PE
Peru
Prior art keywords
methyl
cyclohexyl
alkyl
terc
alcoxy
Prior art date
Application number
PE2008002068A
Other languages
English (en)
Inventor
David Blomberg
Petra Johannesson
Pernilla Sorme
Kay Brickmann
Volker Schnecke
Eric Wellner
Anders Holmen
Ragnar Hovland
Asa Mansson
Alleyn Plowright
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091309A1 publication Critical patent/PE20091309A1/es

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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE CICLOHEXILO DE FORMULA (I), DONDE R1 ES -OR6 O -NR7aR7b; R6 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, CICLOALQUENILO C3-C8, ENTRE OTROS; R7a Y R7b SON H, HETEROCICLILO O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, HALO, ALCOXI C1-C4, ENTRE OTROS; R2 Y R3 SON H, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ENTRE OTROS; R5 ES H O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALO, OH, ALCOXI C1-C6, ENTRE OTROS; E ES ALQUILENO C1; L ES C(O) O SO2; Z ES ARILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS; n ES 0 O 1. SON COMPUESTOS PREFERIDOS: [(TRANS-4-{[({2-[6-(4-METILPIPERAZIN-1-IL)PIRIDIN-3-IL]QUINOLIN-4-IL}CARBONIL)AMINO]METIL}CICLOHEXIL)METIL]CARBAMATO DE TERC-BUTILO, ({TRANS-4-[({[2-(2-METIL-6-OXO-1,6-DIHIDROPIRIDIN-3-IL)QUINOLIN-4-IL]CARBONIL}AMINO)METIL]CICLOHEXIL}METIL)CARBAMATO DE TERC-BUTILO, {[TRANS-4-({[2-PIRAZIN-2-ILQUINOLIN-4-IL)CARBONIL]AMINO}METIL)CICLOHEXIL]METIL}CARBAMATO DE TERC-BUTILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACETIL COENZIMA A CARBOXILASA (ACC) Y SON UTILES EN EL TRATAMIENTO DE LA OBESIDAD Y DIABETES MELLITUS
PE2008002068A 2007-12-21 2008-12-12 Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa PE20091309A1 (es)

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US1578707P 2007-12-21 2007-12-21
US8505908P 2008-07-31 2008-07-31

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US (1) US20090306133A1 (es)
AR (1) AR069920A1 (es)
PE (1) PE20091309A1 (es)
TW (1) TW200932727A (es)
UY (1) UY31554A1 (es)
WO (1) WO2009082346A1 (es)

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