PE20090243A1 - Compuestos de imidazol sustituido como inhibidores de renina - Google Patents
Compuestos de imidazol sustituido como inhibidores de reninaInfo
- Publication number
- PE20090243A1 PE20090243A1 PE2008000701A PE2008000701A PE20090243A1 PE 20090243 A1 PE20090243 A1 PE 20090243A1 PE 2008000701 A PE2008000701 A PE 2008000701A PE 2008000701 A PE2008000701 A PE 2008000701A PE 20090243 A1 PE20090243 A1 PE 20090243A1
- Authority
- PE
- Peru
- Prior art keywords
- piperazin
- imidazol
- carbonyl
- phenyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOL SUSTITUIDOS DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6) SUSTITUIDO CON HIDROXI O FENILAMINO, ARALQUILO(C7-C13), ENTRE OTROS; R2 ES ARILO(C6-C14), CICLOALQUILO(C3-C10), ALQUILO(C1-C10), ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO(C1-C6) O ALCOXI(C1-C6); X ES UN ENLACE O ALQUILENO(C1-C6); A ES CICLOALCANO(C5-C7); B ES PIPERAZINA. SON COMPUESTOS PREFERIDOS: (1S,2R)-1-(METOXIMETIL)-2-{4-[((2R)-2-{2-[(2-METIL-1,3-BENZOTIAZOL-5-IL)OXI]ETIL}PIPERAZIN-1-IL)CARBONIL]-5-FENIL-1H-IMIDAZOL-1-IL}CICLOHEXANOL, [(1S,2S)-2-(4-{[(2R)-2-(3,5-DIFLUOROBENCIL)PIPERAZIN-1-IL]CARBONIL}-5-FENIL-1H-IMIDAZOL-1-IL)CICLOHEXIL]CARBAMATO DE METILO, (1S,2R)-1-(METOXIMETIL)-2-[4-({(2R)-2-[2-(2-METOXI-4-METILFENOXI)ETIL]PIPERAZIN-1-IL}CARBONIL)-5-FENIL-1H-IMIDAZOL-1-IL]CICLOHEXANOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE RENINA SIENDO UTILES EN EL TRATAMIENTO DE HIPERTENSION
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007120292 | 2007-04-27 | ||
JP2007207271 | 2007-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090243A1 true PE20090243A1 (es) | 2009-04-03 |
Family
ID=39657370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000701A PE20090243A1 (es) | 2007-04-27 | 2008-04-23 | Compuestos de imidazol sustituido como inhibidores de renina |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090156612A1 (es) |
AR (1) | AR066268A1 (es) |
CL (1) | CL2008001163A1 (es) |
PE (1) | PE20090243A1 (es) |
TW (1) | TW200904433A (es) |
WO (1) | WO2008139941A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
EA201301040A1 (ru) | 2008-06-19 | 2014-01-30 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение и его применение |
TWI532725B (zh) | 2010-01-26 | 2016-05-11 | 賽諾菲阿凡提斯公司 | 經氧取代之3-雜芳醯基胺基-丙酸衍生物及其作為藥物之用途 |
US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
US9505709B2 (en) | 2014-05-05 | 2016-11-29 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
MX2016016830A (es) | 2014-06-18 | 2017-07-07 | Thetis Pharmaceuticals Llc | Complejos de aminoacidos minerales de agentes activos. |
KR102437682B1 (ko) | 2016-06-03 | 2022-08-29 | 테티스 파마수티컬스 엘엘씨 | 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법 |
US11884662B2 (en) | 2018-05-24 | 2024-01-30 | 3M Innovative Properties Company | N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
US20040214832A1 (en) * | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
JP2009526747A (ja) * | 2006-02-16 | 2009-07-23 | 武田薬品工業株式会社 | 環状アミン化合物および高血圧の予防・治療のための用途 |
-
2008
- 2008-04-23 CL CL2008001163A patent/CL2008001163A1/es unknown
- 2008-04-23 TW TW097114786A patent/TW200904433A/zh unknown
- 2008-04-23 PE PE2008000701A patent/PE20090243A1/es not_active Application Discontinuation
- 2008-04-23 AR ARP080101712A patent/AR066268A1/es unknown
- 2008-04-23 US US12/081,917 patent/US20090156612A1/en not_active Abandoned
- 2008-04-23 WO PCT/JP2008/058310 patent/WO2008139941A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008139941A1 (en) | 2008-11-20 |
CL2008001163A1 (es) | 2008-12-19 |
AR066268A1 (es) | 2009-08-05 |
US20090156612A1 (en) | 2009-06-18 |
TW200904433A (en) | 2009-02-01 |
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Legal Events
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