EA032526B1 - Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы - Google Patents

Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы Download PDF

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EA032526B1
EA032526B1 EA201790406A EA201790406A EA032526B1 EA 032526 B1 EA032526 B1 EA 032526B1 EA 201790406 A EA201790406 A EA 201790406A EA 201790406 A EA201790406 A EA 201790406A EA 032526 B1 EA032526 B1 EA 032526B1
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disease
chemical compound
activity
brain
compound
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EA201790406A
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English (en)
Russian (ru)
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EA201790406A1 (ru
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Стефен Мартин Кортни
Майкл Прайм
Уильям Митчелл
Кристофер Джон Браун
Паула С. Де Агуиар Пена
Питер Джонсон
Селия Домингез
Летиция М. Толедо-Шерман
Игнасио Мунос
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Схди Фаундейшн, Инк.
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Publication of EA201790406A1 publication Critical patent/EA201790406A1/ru
Publication of EA032526B1 publication Critical patent/EA032526B1/ru

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110092266A (ko) 2008-08-04 2011-08-17 씨에이치디아이 파운데이션, 인코포레이티드 소정 키누레닌-3-모노옥시게나아제 억제제, 약학적 조성물, 및 그의 사용 방법
MY166890A (en) * 2011-08-30 2018-07-24 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2972419T3 (es) 2012-04-05 2024-06-12 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas y métodos de uso de los mismos
WO2015047982A2 (en) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
GB201322512D0 (en) * 2013-12-19 2014-02-05 Glaxosmithkline Ip Dev Ltd Novel compounds
CN106061944A (zh) * 2014-01-24 2016-10-26 普渡制药公司 吡啶类和嘧啶类物质及其用途
JP2017520610A (ja) * 2014-07-17 2017-07-27 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ｈｉｖ関連障害を治療するための方法及び組成物
AU2016215432B2 (en) 2015-02-02 2020-07-30 Valo Early Discovery, Inc. 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
KR20180002730A (ko) * 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
AU2016258188B2 (en) * 2015-05-07 2021-08-26 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
CN110381963A (zh) 2016-10-13 2019-10-25 朱诺治疗学股份有限公司 涉及色氨酸代谢途径调节剂的免疫治疗方法和组合物
US11173156B2 (en) * 2019-06-11 2021-11-16 Chdi Foundation, Inc. Solid forms of a kynurenine-3-monooxygenase inhibitor
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
KR20230054685A (ko) 2020-08-06 2023-04-25 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질 이미징을 위한 헤테로바이아릴 화합물 및 이미징제

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080070937A1 (en) * 2006-08-16 2008-03-20 J. David Gladstone Institutes Small molecule inhibitors of kynurenine-3-monooxygenase
US20110183957A1 (en) * 2008-08-04 2011-07-28 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707560A (en) 1970-10-05 1972-12-26 Pfizer Certain 4-amino-6-aryl-pyrimidines
US3908012A (en) 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
FR2204406A1 (en) 1972-10-26 1974-05-24 Delalande Sa 1-Phenyl-3-aminocarbonylpropan-1-one oxime carbamates - with analgesic, antiinflammatory, hypotensive and sedative activities etc.
US3950525A (en) 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
US3935202A (en) 1974-03-18 1976-01-27 American Home Products Corporation 3-(4-biphenylylcarbonyl)propionamido cephalosporin derivatives
US4634689A (en) 1985-10-31 1987-01-06 Schering Corporation Phosphinylalkanoyl imino acids
DE3609596A1 (de) 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
WO1988003136A1 (fr) 1986-10-27 1988-05-05 Yoshitomi Pharmaceutical Industries, Ltd. Composes de piperazine et leur utilisation medicinale
ZW21687A1 (en) 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
GB8629711D0 (en) * 1986-12-12 1987-01-21 Hoffmann La Roche Triazine derivatives
JPH01113377A (ja) 1987-10-23 1989-05-02 Yoshitomi Pharmaceut Ind Ltd ピペラジン化合物
MX16687A (es) 1988-07-07 1994-01-31 Ciba Geigy Ag Compuestos de biarilo y procedimiento para su preparacion.
US5102904A (en) 1989-12-08 1992-04-07 American Cyanamid Company N-oxygenated arylpyrrole insecticidal, acaricidal and nematicidal agents and use thereas
AU644159B2 (en) 1990-05-17 1993-12-02 Novartis Ag 2-anilino-4-cyanopyrimidine derivatives
DE4103695A1 (de) 1991-02-07 1992-08-13 Basf Ag Oximether und diese enthaltende fungizide
US5334720A (en) 1991-03-07 1994-08-02 Fisons Corporation Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
WO1995023135A1 (en) 1991-03-07 1995-08-31 Fisons Corporation Diphenyl-2-piperidinone and -2-pyrrolidinone derivatives having anti-convulsant and neuroprotective activity
JPH0741459A (ja) 1993-07-29 1995-02-10 Sumitomo Pharmaceut Co Ltd 新規エラスターゼ阻害剤
EP0656348B1 (de) 1993-12-03 2000-05-03 F. Hoffmann-La Roche Ag Essigsäurederivate als Arzneimittel
US5338739A (en) 1994-03-10 1994-08-16 Hoechst-Roussel Pharmaceuticals Inc. (Pyrrolidinyl)phenyl carbamates, compositions and use
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
EP0861239B1 (de) 1995-11-17 2003-02-12 Bayer CropScience AG Biphenylether-oxazoline und ihre verwendung als schädlingsbekämpfungsmittel
PL327494A1 (en) 1995-12-22 1998-12-21 Warner Lambert Co Aromatic keto-carboxylic acids and their derivatives as inhibitors of matrix metalloproteinases
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
US5877193A (en) * 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
WO1998009940A1 (en) 1996-09-04 1998-03-12 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
MXPA99001974A (es) 1996-12-09 2002-03-27 Warner Lambert Co Metodo para tratar y prevenir fallas cardiacas y dilatacion ventricular.
DE69727695T2 (de) 1996-12-17 2005-02-10 Warner-Lambert Co. Llc Verwendung von matrix-metalloproteinase inhibitoren zur förderung der wundheilung
WO1998035967A2 (en) 1997-02-18 1998-08-20 Neurocrine Biosciences, Inc. Biazacyclic crf antagonists
PL335235A1 (en) 1997-02-19 2000-04-10 Berlex Lab N-heterocyclic derivatives as nos inhibitors
US5925639A (en) 1997-06-17 1999-07-20 Schering Corporation Keto amide derivatives useful as farnesyl protein transferase inhibitors
AU9663798A (en) 1997-10-06 1999-04-27 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
AU1110799A (en) 1997-10-29 1999-05-17 Warner-Lambert Company Method of inhibiting metastases of cancer cells
HUP0100427A3 (en) 1997-12-23 2002-11-28 Warner Lambert Co Ace inhibitor-mmp inhibitor combinations
US6169103B1 (en) 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
HUP0103714A3 (en) 1998-05-11 2003-05-28 Takeda Pharmaceutical Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity, medicaments containing them and their use
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
DE69912823T2 (de) 1998-09-25 2004-09-23 Astrazeneca Ab Benzamid-derivate und ihre verwendung als cytokine inhibitoren
JP4183350B2 (ja) 1998-10-28 2008-11-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 フェニルピロリジノン誘導体
US6541521B1 (en) 1999-07-12 2003-04-01 Warner-Lambert Company Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
CA2389208A1 (en) 1999-10-29 2001-05-10 Takeda Chemical Industries, Ltd. Process for the preparation of oxyiminoalkanoic acid derivatives
AU1303201A (en) 1999-11-10 2001-06-06 Takeda Chemical Industries Ltd. Alkoxyiminoalkanoic acid derivatives
CA2390932A1 (en) 1999-11-10 2001-05-17 Takeda Chemical Industries, Ltd. Body weight gain inhibitors
GB0003671D0 (en) 2000-02-17 2000-04-05 Univ Cardiff Diphenyl-substituted lower alkanes
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2002040458A1 (en) 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Isoxazole derivatives
US20040077557A1 (en) 2000-12-21 2004-04-22 Sulejman Ali Macrolide antibiotics
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
JP2002241358A (ja) 2001-02-15 2002-08-28 Nippon Soda Co Ltd オキシム基を有する化合物及び殺虫・殺ダニ剤
AR035858A1 (es) * 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
WO2002098840A1 (en) 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
WO2002100332A2 (en) 2001-06-08 2002-12-19 Cytokine Pharmasciences, Inc. Isoxazoline compounds having mif antagonist activity
US6552188B2 (en) 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
ATE396186T1 (de) 2001-10-04 2008-06-15 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
AU2002359714B2 (en) 2001-12-18 2006-12-21 Merck Sharp & Dohme Corp. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
US6949542B2 (en) 2002-02-06 2005-09-27 Hoffman-La Roche Inc. Dihydro-benzo[b][1,4]diazepin-2-one derivatives
JP2005535710A (ja) 2002-08-09 2005-11-24 トランス　テック　ファーマ，インコーポレイテッド アリールおよびヘテロアリール化合物ならびに凝固を調節する方法
WO2004026833A1 (ja) 2002-09-20 2004-04-01 Takeda Pharmaceutical Company Limited 環状アミン化合物、その製造法および用途
AU2003280558A1 (en) 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
CL2003002353A1 (es) 2002-11-15 2005-02-04 Vertex Pharma Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
AU2003293129B2 (en) 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
CA2510298A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
EP1581493A1 (en) 2002-12-30 2005-10-05 Eli Lilly And Company Factor xa inhibitors
US20060293339A1 (en) 2003-03-24 2006-12-28 Chakravarty Prasun K Biaryl substituted 6-membered heterocycles as sodium channel blockers
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
CN1566065A (zh) 2003-06-27 2005-01-19 中国医学科学院药物研究所 α位杂原子取代的γ芳基丁本酮酸衍生物及其制法和其药物组合物与用途
SE0301963D0 (sv) 2003-07-02 2003-07-02 Astrazeneca Ab New compounds
JP2007500128A (ja) 2003-07-25 2007-01-11 アムジエン・インコーポレーテツド 置換複素環式化合物及び使用方法
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
GB0323581D0 (en) 2003-10-08 2003-11-12 Glaxo Group Ltd Novel compounds
US20070099938A1 (en) 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
WO2005042498A2 (en) 2003-10-31 2005-05-12 Neurogen Corporation 4-amino (aza) quinoline derivatives as capsaicin receptor agonists
EP1715867A4 (en) 2004-02-12 2009-04-15 Merck & Co Inc BIPYRIDYLAMIDE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
GB0403155D0 (en) 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
EP1727542A4 (en) 2004-03-26 2009-08-05 Cytokine Pharmasciences Inc COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE FOR INHIBITING MACROPHAGE MIGRATION INHIBITION FACTOR
EP2332940B1 (en) 2004-03-30 2012-10-31 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
WO2006000371A2 (en) 2004-06-28 2006-01-05 F.Hoffmann-La Roche Ag Pyrimidine derivatives as 11beta-hsd1 inhibitors
EP1783116B1 (en) 2004-08-27 2009-08-26 Astellas Pharma Inc. 2-phenylpyridine derivative
WO2006021458A2 (en) 2004-08-27 2006-03-02 Gpc Biotech Ag Pyrimidine derivatives
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
CA2588633A1 (en) 2004-12-07 2006-06-15 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
US20060178388A1 (en) 2005-02-04 2006-08-10 Wrobleski Stephen T Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
BRPI0608581A2 (pt) 2005-03-14 2010-01-19 Transtech Pharma Inc derivados de benzazol, composiÇÕes e mÉtodos de uso como inibidores de b-secretase
CN103173402A (zh) 2005-06-07 2013-06-26 洛克菲勒大学 胰腺β细胞增殖的刺激
EP2388263A1 (en) 2005-08-04 2011-11-23 Sirtris Pharmaceuticals, Inc. Imidazo[2,1-b]thiazole derivatives as sirtuin modulators
WO2007017289A2 (en) 2005-08-10 2007-02-15 Bayer Schering Pharma Aktiengesellschaft Acyltryptophanols for fertility control
US20070060573A1 (en) 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
US20090221547A1 (en) 2005-08-23 2009-09-03 Irm Llc Immunosuppressant Compounds and Compositions
TW200745055A (en) 2005-09-23 2007-12-16 Organon Nv 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
CN102775396B (zh) 2005-11-08 2014-10-08 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的杂环调控剂
EP1960367A2 (en) 2005-12-05 2008-08-27 Boehringer Ingelheim International GmbH Substituted pyrazole compounds useful as soluble epoxide hydrolase inhibitors
JP2009519966A (ja) 2005-12-14 2009-05-21 ブリストル−マイヤーズ スクイブ カンパニー セリンプロテアーゼ阻害剤として有用な６員ヘテロ環
WO2007087637A2 (en) 2006-01-26 2007-08-02 Washington State University Research Foundation Compositions and methods using matrix metalloproteinase (mmp) inhibitors for treating cognitive impairment characterized by persistent or sustained mmp expression and/or activity
US7951824B2 (en) 2006-02-17 2011-05-31 Hoffman-La Roche Inc. 4-aryl-pyridine-2-carboxyamide derivatives
ES2303758B1 (es) * 2006-02-20 2009-08-13 Laboratorios Almirall S.A. Nuevos derivados de piridin-3-amina.
MX2008010646A (es) * 2006-02-24 2008-10-14 Astellas Pharma Inc Agente para tratar o prevenir ulcera digestiva.
JP2007230963A (ja) 2006-03-03 2007-09-13 Daiso Co Ltd ２，４−ジ置換ピリジンの製造法
BRPI0713350B1 (pt) 2006-06-26 2022-04-12 Akebia Therapeutics Inc Composto, e, composição
GB0614579D0 (en) 2006-07-21 2006-08-30 Black James Foundation Pyrimidine derivatives
CL2007002315A1 (es) 2006-08-10 2008-02-22 Glaxo Group Ltd Compuestos derivados de piridina;composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades o trastornos que comprenden el dolor y/o sindrome del intestino irritable.
EP2054397B1 (en) 2006-08-16 2015-10-07 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Small molecule inhibitors of kynurenine-3-monooxygenase
EP2065369A4 (en) 2006-08-23 2011-12-28 Astellas Pharma Inc UREA CONNECTION OR SALT THEREOF
ATE532770T1 (de) 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd Imidazolderivat
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20080077419A1 (en) 2006-09-27 2008-03-27 Santiago Pamela M System And Method For Training Employees Of An Organization To Align Their Job Activities To Achieving The Organization's Strategic Objectives
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US8044209B2 (en) 2006-10-12 2011-10-25 Novartis Ag Pyrrolydine derivatives as IAP inhibitors
WO2008095852A1 (en) 2007-02-08 2008-08-14 Respiratorius Ab Bronchorelaxing arylamides
JP2008266634A (ja) * 2007-03-29 2008-11-06 Sumitomo Chemical Co Ltd 化合物、光電変換素子及び光電気化学電池
US20100101643A1 (en) * 2007-03-29 2010-04-29 Sumitomo Chemical Company, Limited Compound, photoelectric converter and photoelectrochemical cell
JP2010523579A (ja) 2007-04-02 2010-07-15 インスティテュート フォア ワンワールド ヘルス Ｃｆｔｒ阻害剤化合物およびそれらの使用
EP2002834A1 (de) 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors
TWI444379B (zh) 2007-06-29 2014-07-11 Sunesis Pharmaceuticals Inc 有用於作為Ｒａｆ激酶抑制劑之化合物
PE20091309A1 (es) 2007-12-21 2009-09-30 Astrazeneca Ab Derivados de ciclohexilo como inhibidores de acetil coenzima a carboxilasa
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
JP2009280521A (ja) 2008-05-22 2009-12-03 Daiso Co Ltd ２，４−ジ置換ピリジンの製造法
JP2011184298A (ja) 2008-06-02 2011-09-22 Sanwa Kagaku Kenkyusho Co Ltd 新規化合物及びその医薬用途
US20110118262A1 (en) 2008-07-08 2011-05-19 Boehringer Ingelheim International Gmbh Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors
US20110230428A1 (en) 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MX2010014337A (es) 2008-07-25 2011-02-15 Lundbeck & Co As H Derivados de adamantil diamida y usos de los mismos.
WO2010017132A1 (en) 2008-08-04 2010-02-11 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
GB0815369D0 (en) * 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
JP5587784B2 (ja) 2008-10-15 2014-09-10 キッセイ薬品工業株式会社 縮合複素環誘導体及びその医薬用途
EP2340243B1 (en) * 2008-10-17 2014-10-08 Boehringer Ingelheim International GmbH Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
KR20110091537A (ko) * 2008-11-13 2011-08-11 바이엘 크롭사이언스 아게 살진균제로서의 치환 (피리딜)-아지닐아민 유도체
NZ593473A (en) * 2009-01-12 2013-02-22 Pfizer Ltd Sulfonamide derivatives
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
TW201040166A (en) * 2009-04-07 2010-11-16 Astrazeneca Ab Isoxazol-3(2H)-one analogs as therapeutic agents
EA020017B1 (ru) * 2009-04-30 2014-08-29 Новартис Аг Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ
US20120041009A1 (en) 2009-05-18 2012-02-16 Sumitomo Chemical Company, Limited Pyrimidine compound and its use in pest control
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
TWI423962B (zh) * 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
PH12012500713A1 (en) 2009-10-14 2012-11-26 Merck Sharp & Dohme Substituted piperidines that increase p53 activity and the uses thereof
EP2490530A4 (en) 2009-10-22 2014-01-22 Univ Washington COMPOUNDS AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS
US8946197B2 (en) 2009-11-16 2015-02-03 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
US8883785B2 (en) 2010-01-25 2014-11-11 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP5826773B2 (ja) 2010-02-27 2015-12-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ ビスアリール−結合アリールトリアゾロン及びその用途
CN102985418B (zh) 2010-07-02 2015-09-09 吉利德科学股份有限公司 凋亡信号调节激酶抑制剂
KR20130056345A (ko) 2010-09-17 2013-05-29 퍼듀 퍼머 엘피 피리딘 화합물 및 그의 용도
EP2796456A1 (en) 2010-12-09 2014-10-29 Amgen Inc. Bicyclic compounds as Pim inhibitors
HK1198619A1 (en) 2011-07-28 2015-05-22 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MY166890A (en) * 2011-08-30 2018-07-24 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
ES2972419T3 (es) 2012-04-05 2024-06-12 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas y métodos de uso de los mismos
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2015047982A2 (en) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2017520610A (ja) 2014-07-17 2017-07-27 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ｈｉｖ関連障害を治療するための方法及び組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080070937A1 (en) * 2006-08-16 2008-03-20 J. David Gladstone Institutes Small molecule inhibitors of kynurenine-3-monooxygenase
US20110183957A1 (en) * 2008-08-04 2011-07-28 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof

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