BR9714142A - Uso de inibidores de metaloproteìnases matriciais para tratamento de distúrbios neurológicos e promoção de cicatrização de feridas - Google Patents

Uso de inibidores de metaloproteìnases matriciais para tratamento de distúrbios neurológicos e promoção de cicatrização de feridas

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Publication number
BR9714142A
BR9714142A BR9714142-9A BR9714142A BR9714142A BR 9714142 A BR9714142 A BR 9714142A BR 9714142 A BR9714142 A BR 9714142A BR 9714142 A BR9714142 A BR 9714142A
Authority
BR
Brazil
Prior art keywords
wound healing
matrix metalloproteinase
neurological disorders
metalloproteinase inhibitors
promote wound
Prior art date
Application number
BR9714142-9A
Other languages
English (en)
Inventor
Thomas Michael Andrew Bocan
Peter Alan Boxer
Joseph Thomas Peterson Jr
Denis Schrier
Andrew David White
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9714142A publication Critical patent/BR9714142A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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Abstract

Patente de Invenção: <B>''USO DE INIBIDORES DE METALOPROTEINASES MATRICIAIS PARA TRATAMENTO DE DISTúRBIOS NEUROLóGICOS E PROMOçãO DE CICATRIZAçãO DE FERIDAS''<D>. Esta invenção refere-se a inibidores de metaloproteinases matriciais os quais são úteis para prevenção e tratamento de distúrbios neurológicos e promoção de cicatrização de feridas.
BR9714142-9A 1996-12-17 1997-11-21 Uso de inibidores de metaloproteìnases matriciais para tratamento de distúrbios neurológicos e promoção de cicatrização de feridas BR9714142A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3275396P 1996-12-17 1996-12-17
PCT/US1997/021532 WO1998026773A1 (en) 1996-12-17 1997-11-21 Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing

Publications (1)

Publication Number Publication Date
BR9714142A true BR9714142A (pt) 2000-02-29

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US (1) US6340709B1 (pt)
EP (1) EP0946166B1 (pt)
JP (1) JP2001507342A (pt)
AT (1) ATE259640T1 (pt)
AU (1) AU737117B2 (pt)
BR (1) BR9714142A (pt)
CA (1) CA2264692A1 (pt)
DE (1) DE69727695T2 (pt)
DK (1) DK0946166T3 (pt)
ES (1) ES2212142T3 (pt)
NZ (1) NZ334925A (pt)
PT (1) PT946166E (pt)
WO (1) WO1998026773A1 (pt)
ZA (1) ZA9711279B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL326700A1 (en) * 1995-11-17 1998-10-26 Warner Lambert Co Sulphonamide-based inhibitors of intercellular substance metaloproteinases
DE69619865T2 (de) * 1995-12-22 2002-11-07 Warner Lambert Co Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
CN1195735C (zh) * 1998-02-04 2005-04-06 诺瓦提斯公司 抑制使基质退化的金属蛋白酶的磺酰氨基衍生物
WO2000024392A1 (fr) * 1998-10-26 2000-05-04 Sumitomo Pharmaceuticals Company, Limited Inhibiteur de la formation de beta-amyloide
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) * 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
JP4074043B2 (ja) 2000-03-27 2008-04-09 株式会社資生堂 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法
US6376524B1 (en) 2000-06-21 2002-04-23 Sunesis Pharmaceuticals, Inc. Triphenyl compounds as interleukin-4 antagonists
AU2001271068A1 (en) * 2000-07-18 2002-01-30 Chugai Seiyaku Kabushiki Kaisha Matrix metalloprotease inhibitors
JP2004509941A (ja) 2000-09-29 2004-04-02 プロリフィクス　リミテッド Ｈｄａｃインヒビターとしてのアミド結合を含むカルバミン酸化合物
US7173053B2 (en) * 2000-11-23 2007-02-06 British Biotech Pharmaceuticals Limited N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
WO2003006006A1 (en) * 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
GB0204159D0 (en) * 2002-02-22 2002-04-10 British Biotech Pharm Metalloproteinase inhibitors
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1796681A2 (en) * 2004-08-02 2007-06-20 Genmedica Therapeutics SL Compounds for inhibiting copper-containing amine oxidases and uses thereof
GB0708507D0 (en) 2007-05-02 2007-06-13 Queen Mary & Westfield College Substituted phosphonates and their use
US20090136718A1 (en) * 2007-11-28 2009-05-28 Paul Dacey Reinforced Bonded Constructs
US20110230428A1 (en) * 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
PL2750677T4 (pl) 2011-08-30 2017-12-29 Chdi Foundation, Inc. Inhibitory 3-monooksygenazy kinureninowej, kompozycje farmaceutyczne i sposoby ich stosowania
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EP3169684B1 (en) 2014-07-17 2019-06-26 CHDI Foundation, Inc. Combination of kmo inhibitor 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid with antiviral agent for treating hiv related neurological disorders
CN111249281B (zh) * 2020-03-26 2020-11-24 徐州医科大学 Trpml1特异性小分子抑制剂ml-si3的新用途
BR112023005344A2 (pt) * 2020-09-23 2023-05-09 St Jude Childrens Res Hospital Inc Análogos de n-(2-(2,6-dioxopiperidin-3-il)-1,3-dioxoisoindolin- 5-il)arilsulfonamida substituídos como moduladores da proteína cereblon
KR102612229B1 (ko) * 2021-05-21 2023-12-08 가천대학교 산학협력단 N-[(4'-브로모[1,1'-바이페닐]-4-일)설포닐]-l-발린 또는 이의 약제학적으로 허용 가능한 염을 포함하는 아밀로이드 베타의 올리고머화 및 피브릴화 억제용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784701A (en) 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5602156A (en) 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
WO1996011209A1 (en) 1994-10-05 1996-04-18 Chiroscience Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
PT828726E (pt) * 1995-06-02 2002-03-28 Warner Lambert Co Inibidores triciclicos de metaloproteinases de matriz
PL326700A1 (en) * 1995-11-17 1998-10-26 Warner Lambert Co Sulphonamide-based inhibitors of intercellular substance metaloproteinases
DE69619865T2 (de) * 1995-12-22 2002-11-07 Warner Lambert Co Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase
CA2253342A1 (en) * 1996-05-17 1997-11-27 Warner-Lambert Company Biphenylsulfonamide matrix metalloproteinase inhibitors

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ES2212142T3 (es) 2004-07-16
WO1998026773A1 (en) 1998-06-25
AU737117B2 (en) 2001-08-09
ATE259640T1 (de) 2004-03-15
US6340709B1 (en) 2002-01-22
DK0946166T3 (da) 2004-05-03
EP0946166A1 (en) 1999-10-06
ZA9711279B (en) 1998-06-23
PT946166E (pt) 2004-06-30
DE69727695D1 (de) 2004-03-25
DE69727695T2 (de) 2005-02-10
JP2001507342A (ja) 2001-06-05
NZ334925A (en) 2001-06-29
AU7735398A (en) 1998-07-15
EP0946166B1 (en) 2004-02-18
CA2264692A1 (en) 1998-06-25

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