MX364378B - Inhibidores de la quinurenina-3-monooxigenasa, sus composiciones farmaceuticas y metodos para uso. - Google Patents
Inhibidores de la quinurenina-3-monooxigenasa, sus composiciones farmaceuticas y metodos para uso.Info
- Publication number
- MX364378B MX364378B MX2014002460A MX2014002460A MX364378B MX 364378 B MX364378 B MX 364378B MX 2014002460 A MX2014002460 A MX 2014002460A MX 2014002460 A MX2014002460 A MX 2014002460A MX 364378 B MX364378 B MX 364378B
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- chemical entity
- pharmaceutical compositions
- administering
- kynurenine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Se proporcionan en la presente ciertas entidades químicas. Se proporcionan también composiciones farmacéuticas que comrpenden por lo menos una entidad química y uno o más vehículos farmacéuticamente aceptables. Se describen métodos para tratar a pacientes que sufren de ciertas enfermedades y padecimientos que responden a la inhibición de la actividad de KMO, los cuales comprenden administrara esos pacientes una cantidad de por lo menos una entidad química efectiva para reducir los signos o síntomas de la enfermedad o padecimiento. Estas enfermedades incluyen padecimientos neurodegenerativos tales como la enfermedad de Huntington. Se describen también métodos de tratamiento que incluyen administrar por lo menos una entidad química en combinación con uno o más agentes terapéuticos. De igual manera, se proporcionan métodos para probar compuestos capaces de inhibir la actividad de KMO.
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