CN111108083A - 氨基亚甲基环己烷1,3-二酮化合物的用途 - Google Patents

氨基亚甲基环己烷1,3-二酮化合物的用途 Download PDF

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CN111108083A
CN111108083A CN201880033796.7A CN201880033796A CN111108083A CN 111108083 A CN111108083 A CN 111108083A CN 201880033796 A CN201880033796 A CN 201880033796A CN 111108083 A CN111108083 A CN 111108083A
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cancer
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autophagy
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diseases
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CN111108083B (zh
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罗成
乐立艳
万伟
张元元
蒋华良
陈凯先
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Wigen Biomedicine Technology Shanghai Co Ltd
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Abstract

本发明涉及氨基亚甲基环己烷1,3‑二酮化合物的用途，具体涉及下式(I)所示化合物或其药学上可接受的盐单独或者与其他药物联合在制备调节细胞自噬及治疗细胞自噬，特别是哺乳动物ATG8同源蛋白，相关的疾病的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880033796.7A 2017-05-22 2018-05-18 氨基亚甲基环己烷1,3-二酮化合物的用途 Active CN111108083B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017103649099 2017-05-22
CN201710364909.9A CN108938612A (zh) 2017-05-22 2017-05-22 氨基亚甲基环己烷1,3-二酮化合物的用途
PCT/CN2018/087452 WO2018214814A1 (zh) 2017-05-22 2018-05-18 氨基亚甲基环己烷1,3-二酮化合物的用途

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CN111108083A true CN111108083A (zh) 2020-05-05
CN111108083B CN111108083B (zh) 2022-07-15

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2011033389A2 (en) * 2009-09-17 2011-03-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives Plant additives and uses thereof to modulate the synthesis of membrane glycerolipids in planta
CN103977002A (zh) * 2014-05-30 2014-08-13 中国药科大学 诱发自噬的2-氨基烟腈类化合物及其用途
US20150166492A1 (en) * 2013-12-12 2015-06-18 Albert Einstein College Of Medicine Of Yeshiva University Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090163545A1 (en) * 2007-12-21 2009-06-25 University Of Rochester Method For Altering The Lifespan Of Eukaryotic Organisms
WO2011033389A2 (en) * 2009-09-17 2011-03-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives Plant additives and uses thereof to modulate the synthesis of membrane glycerolipids in planta
US20150166492A1 (en) * 2013-12-12 2015-06-18 Albert Einstein College Of Medicine Of Yeshiva University Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
CN103977002A (zh) * 2014-05-30 2014-08-13 中国药科大学 诱发自噬的2-氨基烟腈类化合物及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARÍA-DOLORES CANELA 等: "Novel Colchicine-Site Binders with a Cyclohexanedione Scaffold Identified through a Ligand-Based Virtual Screening Approach", 《J. MED. CHEM.》 *
MARÍA-DOLORES CANELA 等: "Targeting the colchicine site in tubulin through cyclohexanedione derivatives", 《RSC ADV》 *

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