JP2016104026A5 - - Google Patents
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- JP2016104026A5 JP2016104026A5 JP2016004910A JP2016004910A JP2016104026A5 JP 2016104026 A5 JP2016104026 A5 JP 2016104026A5 JP 2016004910 A JP2016004910 A JP 2016004910A JP 2016004910 A JP2016004910 A JP 2016004910A JP 2016104026 A5 JP2016104026 A5 JP 2016104026A5
- Authority
- JP
- Japan
- Prior art keywords
- amyloid
- antibody
- disease
- fragment
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 35
- 239000012634 fragment Substances 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 24
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 21
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 21
- 201000010099 disease Diseases 0.000 claims 18
- 208000035475 disorder Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 12
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims 8
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 8
- 206010002022 amyloidosis Diseases 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 201000008319 inclusion body myositis Diseases 0.000 claims 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001149 cognitive effect Effects 0.000 claims 3
- 230000007087 memory ability Effects 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- LZXHHNKULPHARO-UHFFFAOYSA-M (3,4-dichlorophenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].C1=C(Cl)C(Cl)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LZXHHNKULPHARO-UHFFFAOYSA-M 0.000 claims 2
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Amino-1-propanesulfonic acid Natural products NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims 2
- 208000023769 AA amyloidosis Diseases 0.000 claims 2
- 208000018282 ACys amyloidosis Diseases 0.000 claims 2
- 206010065040 AIDS dementia complex Diseases 0.000 claims 2
- 206010007509 Cardiac amyloidosis Diseases 0.000 claims 2
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 2
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 2
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 2
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims 2
- 208000032849 Hereditary cerebral hemorrhage with amyloidosis Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 201000002832 Lewy body dementia Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000007660 Residual Neoplasm Diseases 0.000 claims 2
- 206010039811 Secondary amyloidosis Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000000975 bioactive effect Effects 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000011523 endocrine gland cancer Diseases 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 1
- 229940125373 Gamma-Secretase Inhibitor Drugs 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000003942 amyloidogenic effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000002439 beta secretase inhibitor Substances 0.000 claims 1
- 229940088623 biologically active substance Drugs 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 208000037765 diseases and disorders Diseases 0.000 claims 1
- 229960003530 donepezil Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- 239000003540 gamma secretase inhibitor Substances 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000011835 investigation Methods 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000001050 pharmacotherapy Methods 0.000 claims 1
- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 claims 1
- 229960004633 pirenzepine Drugs 0.000 claims 1
- MGNVWUDMMXZUDI-UHFFFAOYSA-N propane-1,3-disulfonic acid Chemical compound OS(=O)(=O)CCCS(O)(=O)=O MGNVWUDMMXZUDI-UHFFFAOYSA-N 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical group C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05027092.5 | 2005-12-12 | ||
| EP05027092 | 2005-12-12 | ||
| EP06014729.5 | 2006-07-14 | ||
| EP06014729 | 2006-07-14 | ||
| EP06020766.9 | 2006-10-02 | ||
| EP06020766 | 2006-10-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013216451A Division JP2014039561A (ja) | 2005-12-12 | 2013-10-17 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017069675A Division JP2017153480A (ja) | 2005-12-12 | 2017-03-31 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016104026A JP2016104026A (ja) | 2016-06-09 |
| JP2016104026A5 true JP2016104026A5 (enExample) | 2016-08-18 |
| JP6174727B2 JP6174727B2 (ja) | 2017-08-02 |
Family
ID=37896141
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544834A Active JP5419131B2 (ja) | 2005-12-12 | 2006-12-08 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2010039568A Withdrawn JP2010187674A (ja) | 2005-12-12 | 2010-02-25 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2013216451A Withdrawn JP2014039561A (ja) | 2005-12-12 | 2013-10-17 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2016004910A Active JP6174727B2 (ja) | 2005-12-12 | 2016-01-14 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2017069675A Ceased JP2017153480A (ja) | 2005-12-12 | 2017-03-31 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544834A Active JP5419131B2 (ja) | 2005-12-12 | 2006-12-08 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2010039568A Withdrawn JP2010187674A (ja) | 2005-12-12 | 2010-02-25 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| JP2013216451A Withdrawn JP2014039561A (ja) | 2005-12-12 | 2013-10-17 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017069675A Ceased JP2017153480A (ja) | 2005-12-12 | 2017-03-31 | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US7772375B2 (enExample) |
| EP (3) | EP1959996A2 (enExample) |
| JP (5) | JP5419131B2 (enExample) |
| KR (4) | KR101505201B1 (enExample) |
| AR (1) | AR058326A1 (enExample) |
| AU (1) | AU2006326284B2 (enExample) |
| BR (1) | BRPI0619748B8 (enExample) |
| CA (1) | CA2632822C (enExample) |
| CL (1) | CL2011000010A1 (enExample) |
| CR (3) | CR9995A (enExample) |
| CY (1) | CY1115014T1 (enExample) |
| DK (1) | DK2361638T3 (enExample) |
| EC (1) | ECSP088530A (enExample) |
| ES (1) | ES2454253T3 (enExample) |
| HR (2) | HRP20140251T1 (enExample) |
| IL (6) | IL191230A (enExample) |
| MA (1) | MA30163B1 (enExample) |
| MX (2) | MX2008007477A (enExample) |
| MY (1) | MY167887A (enExample) |
| NO (1) | NO345996B1 (enExample) |
| NZ (1) | NZ568012A (enExample) |
| PH (1) | PH12011502389A1 (enExample) |
| PL (1) | PL2361638T3 (enExample) |
| PT (1) | PT2361638E (enExample) |
| RS (1) | RS53291B (enExample) |
| RU (2) | RU2551782C2 (enExample) |
| SG (1) | SG10201404801YA (enExample) |
| SI (1) | SI2361638T1 (enExample) |
| TW (2) | TWI508975B (enExample) |
| WO (1) | WO2007068412A2 (enExample) |
| ZA (1) | ZA200804916B (enExample) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US10533998B2 (en) * | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| WO2004092197A2 (en) * | 2003-04-07 | 2004-10-28 | The Regents Of The University Of California | Amyloid-specific peptides and uses thereof |
| KR101667623B1 (ko) | 2005-11-30 | 2016-10-19 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| KR101152557B1 (ko) | 2005-12-12 | 2012-09-07 | 에이씨 이뮨 에스.에이. | 치료 백신 |
| MY167887A (en) * | 2005-12-12 | 2018-09-26 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| US7959949B2 (en) | 2006-04-27 | 2011-06-14 | University Of Central Florida Research Foundation, Inc. | Functionalized nanoceria composition for ophthalmic treatment |
| WO2008011348A2 (en) * | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Humanized antibody against amyloid beta |
| KR20160049045A (ko) * | 2006-07-14 | 2016-05-04 | 에이씨 이뮨 에스.에이. | 아밀로이드 베타에 대해 인간화된 항체 |
| EP3988566A1 (en) * | 2006-07-14 | 2022-04-27 | AC Immune SA | Humanized antibody against amyloid beta |
| DK2074145T5 (en) * | 2006-10-02 | 2017-10-16 | Ac Immune Sa | HUMANIZED ANTIBODY AGAINST AMYLOID BETA |
| EP2102165A2 (en) | 2006-11-24 | 2009-09-23 | AC Immune S.A. | N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| PL2426143T3 (pl) | 2007-01-05 | 2017-12-29 | University Of Zurich | Sposób zapewniania specyficznych wobec choroby cząsteczek wiążących i celów |
| EP2104682B1 (en) | 2007-01-11 | 2016-09-21 | Michael Bacher | Diagnosis and treatment of alzheimer's and other neurodementing diseases |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| US20090022728A1 (en) * | 2007-03-09 | 2009-01-22 | Rinat Neuroscience Corporation | Methods of treating ophthalmic diseases |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| WO2008141321A1 (en) | 2007-05-14 | 2008-11-20 | Medtronic, Inc. | Methods and device to neutralize soluble toxic agents in the brain |
| US8323654B2 (en) * | 2007-05-14 | 2012-12-04 | Medtronic, Inc. | Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules |
| US20090232801A1 (en) * | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
| ES2529174T3 (es) * | 2007-06-12 | 2015-02-17 | Ac Immune S.A. | Anticuerpos humanizados para amiloide beta |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US9119391B1 (en) | 2007-07-16 | 2015-09-01 | University Of Central Florida Research Foundation, Inc. | Polymer coated ceria nanoparticles for selective cytoprotection |
| RU2542967C2 (ru) * | 2007-10-05 | 2015-02-27 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| AU2015200604B2 (en) * | 2007-10-05 | 2016-10-27 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| US9403902B2 (en) * | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
| BRPI0818621A8 (pt) * | 2007-10-05 | 2018-01-30 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa e a quantidade de placas na camada de célula de gânglio retinal de um indivíduo, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular, para diagnosticar uma doença ocular e uma predisposição a uma doença ocular, para monitorar doença ocular, para predizer responsividade de um paciente, e para reter ou diminuir pressão ocular nos olhos de um indivíduo |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009104736A1 (ja) * | 2008-02-22 | 2009-08-27 | 財団法人ヒューマンサイエンス振興財団 | 組織アミロイドプラーク親和性抗体及びそれを用いた医薬組成物 |
| US8916199B1 (en) | 2008-04-25 | 2014-12-23 | University of Central Florida Research Foundation, Ind. | Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide |
| WO2009132277A1 (en) * | 2008-04-25 | 2009-10-29 | The Board Of Regents Of The University Of Oklahoma | Inhibition of neovascularization by cerium oxide nanoparticles |
| AT506820B1 (de) * | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| CA2730073A1 (en) * | 2008-07-09 | 2010-01-14 | University Of Zurich | Method of promoting neurogenesis |
| US9127202B1 (en) | 2008-07-18 | 2015-09-08 | University Of Central Florida Research Foundation, Inc. | Biocompatible nano rare earth oxide upconverters for imaging and therapeutics |
| CN105481980A (zh) | 2008-07-21 | 2016-04-13 | 前体生物药物股份公司 | 诊断抗体测定 |
| EP2149380A1 (en) * | 2008-07-29 | 2010-02-03 | Medivet Pharma, S.L. | Veterinary immunotherapy compositions for the Aged Related Cognitive Dysfunction. |
| DK2370466T3 (en) | 2008-12-19 | 2015-08-03 | Univ Zuerich | Humane anti-alpha-synuclein-autoantistoffer |
| US8883519B1 (en) | 2009-03-17 | 2014-11-11 | University Of Central Florida Research Foundation, Inc. | Oxidase activity of polymeric coated cerium oxide nanoparticles |
| US9585840B1 (en) | 2009-07-10 | 2017-03-07 | University Of Central Florida Research Foundation, Inc. | Redox active cerium oxide nanoparticles and associated methods |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| US8795731B1 (en) | 2009-10-12 | 2014-08-05 | University Of Central Florida Research Foundation, Inc. | Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation |
| EP2311823A1 (en) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
| CN102051407B (zh) * | 2009-11-09 | 2012-12-12 | 中国医学科学院医药生物技术研究所 | Hiv-1前体蛋白早成熟化诱导剂的筛选方法 |
| CA2788275A1 (en) | 2010-03-03 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Biparatopic abeta binding polypeptides |
| US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2545047B9 (en) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| CN102933601B (zh) | 2010-04-15 | 2016-06-08 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| NZ602777A (en) | 2010-04-16 | 2014-07-25 | Ac Immune Sa | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| US20110256064A1 (en) | 2010-04-16 | 2011-10-20 | Ac Immune, S.A. | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
| WO2012020124A1 (en) | 2010-08-12 | 2012-02-16 | Ac Immune S.A. | Vaccine engineering |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
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