JP2010505415A5 - - Google Patents
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- JP2010505415A5 JP2010505415A5 JP2009531414A JP2009531414A JP2010505415A5 JP 2010505415 A5 JP2010505415 A5 JP 2010505415A5 JP 2009531414 A JP2009531414 A JP 2009531414A JP 2009531414 A JP2009531414 A JP 2009531414A JP 2010505415 A5 JP2010505415 A5 JP 2010505415A5
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- Prior art keywords
- seq
- fragment
- antibody
- amino acid
- xaa
- Prior art date
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 31
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 31
- 230000001149 cognitive effect Effects 0.000 claims description 30
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 29
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- 206010002022 amyloidosis Diseases 0.000 claims description 19
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims description 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
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- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims description 13
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- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims description 6
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- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 6
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 6
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- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 6
- 201000010374 Down Syndrome Diseases 0.000 claims description 6
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims description 6
- 208000032849 Hereditary cerebral hemorrhage with amyloidosis Diseases 0.000 claims description 6
- 201000002832 Lewy body dementia Diseases 0.000 claims description 6
- 208000012902 Nervous system disease Diseases 0.000 claims description 6
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- 108010073025 phenylalanylphenylalanine Proteins 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
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- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 4
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- LZXHHNKULPHARO-UHFFFAOYSA-M (3,4-dichlorophenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].C1=C(Cl)C(Cl)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LZXHHNKULPHARO-UHFFFAOYSA-M 0.000 description 2
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Amino-1-propanesulfonic acid Natural products NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 description 2
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- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 2
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- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 2
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- NPWMTBZSRRLQNJ-VKHMYHEASA-N (3s)-3-aminopiperidine-2,6-dione Chemical compound N[C@H]1CCC(=O)NC1=O NPWMTBZSRRLQNJ-VKHMYHEASA-N 0.000 description 1
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- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
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- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 description 1
- 229960004633 pirenzepine Drugs 0.000 description 1
- MGNVWUDMMXZUDI-UHFFFAOYSA-N propane-1,3-disulfonic acid Chemical compound OS(=O)(=O)CCCS(O)(=O)=O MGNVWUDMMXZUDI-UHFFFAOYSA-N 0.000 description 1
- 238000012552 review Methods 0.000 description 1
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Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014730 | 2006-07-14 | ||
| EP06020766 | 2006-10-02 | ||
| EP06020765.1 | 2006-10-02 | ||
| EP06020765 | 2006-10-02 | ||
| EP06020766.9 | 2006-10-02 | ||
| US94328907P | 2007-06-11 | 2007-06-11 | |
| US60/943,289 | 2007-06-11 | ||
| US94349907P | 2007-06-12 | 2007-06-12 | |
| US60/943,499 | 2007-06-12 | ||
| USPCT/US2007/073504 | 2007-07-13 | ||
| PCT/US2007/073504 WO2008011348A2 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
| PCT/US2007/021134 WO2008060364A2 (en) | 2006-10-02 | 2007-10-02 | Humani zed antibody against amyloid beta |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014136443A Division JP2014223075A (ja) | 2006-10-02 | 2014-07-02 | アミロイドβに対するヒト化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010505415A JP2010505415A (ja) | 2010-02-25 |
| JP2010505415A5 true JP2010505415A5 (enExample) | 2010-11-18 |
| JP5641737B2 JP5641737B2 (ja) | 2014-12-17 |
Family
ID=43063574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531414A Active JP5641737B2 (ja) | 2006-07-14 | 2007-10-02 | アミロイドβに対するヒト化抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US7892544B2 (enExample) |
| EP (2) | EP2046833B9 (enExample) |
| JP (1) | JP5641737B2 (enExample) |
| KR (2) | KR101605207B1 (enExample) |
| AR (1) | AR062065A1 (enExample) |
| AU (1) | AU2007275467B2 (enExample) |
| CA (1) | CA2657681C (enExample) |
| CL (1) | CL2007002070A1 (enExample) |
| CO (1) | CO6150201A2 (enExample) |
| CR (1) | CR10556A (enExample) |
| HR (1) | HRP20090221B1 (enExample) |
| IL (1) | IL196478B (enExample) |
| MA (1) | MA30632B1 (enExample) |
| MX (2) | MX2009000476A (enExample) |
| NO (2) | NO344963B1 (enExample) |
| NZ (1) | NZ574188A (enExample) |
| PL (2) | PL2046833T3 (enExample) |
| RU (1) | RU2498999C2 (enExample) |
| SG (1) | SG173385A1 (enExample) |
| TW (1) | TWI551607B (enExample) |
| WO (1) | WO2008011348A2 (enExample) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| JP5419131B2 (ja) * | 2005-12-12 | 2014-02-19 | エーシー イミューン ソシエテ アノニム | 治療的特性を有するβ１〜４２特異的モノクローナル抗体 |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| TWI551607B (zh) * | 2006-07-14 | 2016-10-01 | Ａｃ免疫公司 | 人類化抗體 |
| CN101611054B (zh) * | 2006-10-02 | 2013-12-25 | Ac免疫有限公司 | 针对淀粉状蛋白β的人源化抗体 |
| BRPI0719379A2 (pt) | 2006-11-24 | 2014-02-11 | Ac Immune Sa | Composto, composição farmacêutica, uso de composto, mistura, métodos para coletar dados para o diagnóstico de uma doença ou condição associada com amilóide em uma amostra ou um paciente, para determinar a extensão da carga de placa amiloidogênica em um tecido e/ou um fluido corporal, para coletar dados para determinar a predisposição a uma doença ou condição associada com amilóide em um paciente, para coletar dados para monitorar a doença residual mínima em um paciente seguindo o tratamento com um anticorpo ou uma composição de vacina e para coletar dados para predizer a responsividade de um paciente sendo tratado com um anticorpo ou uma composição de vacina, e, kit de teste |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US20090022728A1 (en) * | 2007-03-09 | 2009-01-22 | Rinat Neuroscience Corporation | Methods of treating ophthalmic diseases |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US20090232801A1 (en) * | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| SG182192A1 (en) * | 2007-06-12 | 2012-07-30 | Ac Immune Sa | Humanized antibodies to amyloid beta |
| JP5889529B2 (ja) | 2007-07-27 | 2016-03-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | アミロイド原性疾患の処置 |
| GB0718737D0 (en) * | 2007-09-25 | 2007-11-07 | Glaxo Group Ltd | Antibodies |
| CA2701793C (en) * | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
| AU2008311365B2 (en) * | 2007-10-05 | 2015-03-12 | Ac Immune S.A. | Humanized antibody |
| RU2542967C2 (ru) * | 2007-10-05 | 2015-02-27 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| JPWO2009104736A1 (ja) * | 2008-02-22 | 2011-06-23 | 田平 武 | 組織アミロイドプラーク親和性抗体及びそれを用いた医薬組成物 |
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| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| SG182192A1 (en) * | 2007-06-12 | 2012-07-30 | Ac Immune Sa | Humanized antibodies to amyloid beta |
| AR066987A1 (es) | 2007-06-12 | 2009-09-23 | Ac Immune Sa | Anticuerpo monoclonal contra proteina beta-amiloide |
| AU2008311365B2 (en) | 2007-10-05 | 2015-03-12 | Ac Immune S.A. | Humanized antibody |
| RU2542967C2 (ru) | 2007-10-05 | 2015-02-27 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
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2007
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- 2007-07-13 CL CL200702070A patent/CL2007002070A1/es unknown
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