CO6150201A2 - Anticuerpo humanizado contra beta amiloide - Google Patents

Anticuerpo humanizado contra beta amiloide

Info

Publication number
CO6150201A2
CO6150201A2 CO09007328A CO09007328A CO6150201A2 CO 6150201 A2 CO6150201 A2 CO 6150201A2 CO 09007328 A CO09007328 A CO 09007328A CO 09007328 A CO09007328 A CO 09007328A CO 6150201 A2 CO6150201 A2 CO 6150201A2
Authority
CO
Colombia
Prior art keywords
phe
leu
xaa3
fragment
humanized antibody
Prior art date
Application number
CO09007328A
Other languages
English (en)
Inventor
Andrea Pfeifer
Maria Pihlgren
Andreas Muhs
Ryan J Watts
Original Assignee
Ac Immune Sa
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43063574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6150201(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Immune Sa, Genentech Inc filed Critical Ac Immune Sa
Publication of CO6150201A2 publication Critical patent/CO6150201A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1.- Un anticuerpo quimérico o un fragmento del mismo, o un anticuerpo humanizado o un fragmento del mismo, que se une específicamente a al menos un epítope en la proteína amiloide-ß en donde el epítope comprende al menos dos residuos de aminoácido consecutivos - Lys - Leu - predominantemente involucrados en la unión al anticuerpo dentro de la siguiente secuencia nuclear Xaa1 - Xaa2 - Lys - Leu - Xaa3 (SEC ID No.: 10) en donde Xaa1 es His, Asn, GIn Lys o Arg; Xaa2 es Asn o GIn; y Xaa3 es Ala, Val, Leu, norleucina, Met, Phe e Ile. 2.- Un anticuerpo quimérico o un fragmento del mismo, o un anticuerpo humanizado o un fragmento del mismo, que se une específicamente a al menos un epitope en la proteína amiloide-ß en donde dicho epítope comprende al menos dos residuos de aminoácido consecutivos - Phe - Phe - predominantemente involucrados en la unión al anticuerpo dentro de la siguiente secuencia nuclear (SEC ID No.: 9): Xaa3 - Phe - Phe - Xaa4 - Xaa5 - Xaa6, en donde Xaa3 es Ala, Val, Leu, norleucina, Met, Phe o Ile; Xaa4 es Ala, Val, Leu, Ser o Ile; Xaa5 es Glu o Asp, y Xaa6 es Glu o Asp.
CO09007328A 2006-07-14 2009-01-27 Anticuerpo humanizado contra beta amiloide CO6150201A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP06014730 2006-07-14
EP06020766 2006-10-02
EP06020765 2006-10-02
US94328907P 2007-06-11 2007-06-11
US94349907P 2007-06-12 2007-06-12
EP07840408.4A EP2046833B9 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta

Publications (1)

Publication Number Publication Date
CO6150201A2 true CO6150201A2 (es) 2010-04-20

Family

ID=43063574

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09007328A CO6150201A2 (es) 2006-07-14 2009-01-27 Anticuerpo humanizado contra beta amiloide

Country Status (21)

Country Link
US (5) US7892544B2 (es)
EP (2) EP2468770B1 (es)
JP (1) JP5641737B2 (es)
KR (2) KR101605207B1 (es)
AR (1) AR062065A1 (es)
AU (1) AU2007275467B2 (es)
CA (1) CA2657681C (es)
CL (1) CL2007002070A1 (es)
CO (1) CO6150201A2 (es)
CR (1) CR10556A (es)
HR (1) HRP20090221B1 (es)
IL (1) IL196478B (es)
MA (1) MA30632B1 (es)
MX (2) MX2009000476A (es)
NO (2) NO344963B1 (es)
NZ (1) NZ574188A (es)
PL (2) PL2046833T3 (es)
RU (1) RU2498999C2 (es)
SG (1) SG173385A1 (es)
TW (1) TWI551607B (es)
WO (1) WO2008011348A2 (es)

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