MX388197B - Método para la reducción de proteínas de células hospederas en cromatografía de afinidad. - Google Patents

Método para la reducción de proteínas de células hospederas en cromatografía de afinidad.

Info

Publication number
MX388197B
MX388197B MX2018001536A MX2018001536A MX388197B MX 388197 B MX388197 B MX 388197B MX 2018001536 A MX2018001536 A MX 2018001536A MX 2018001536 A MX2018001536 A MX 2018001536A MX 388197 B MX388197 B MX 388197B
Authority
MX
Mexico
Prior art keywords
host cell
affinity chromatography
reduction
cell proteins
purifying
Prior art date
Application number
MX2018001536A
Other languages
English (en)
Other versions
MX2018001536A (es
Inventor
Annika Kleinjans
Benjamin Tran
Bernhard Spensberger
Carina Kopp
Frank Zettl
Klaus Schwendner
Marc Wong
Michael Wiedmann
Paul Mcdonald
John Richard St
Roberto Falkenstein
Ryan Erickson
Wolfgang Koehnlein
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56802471&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX388197(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of MX2018001536A publication Critical patent/MX2018001536A/es
Publication of MX388197B publication Critical patent/MX388197B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

La presente invención se refiere a un método para purificar un anticuerpo reduciendo el contenido de una proteína de la célula hospedera. El método emplea una etapa de lavado con una solución acuosa de baja conductividad en una cromatografía de afinidad.
MX2018001536A 2015-08-21 2016-08-18 Método para la reducción de proteínas de células hospederas en cromatografía de afinidad. MX388197B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562208523P 2015-08-21 2015-08-21
PCT/EP2016/069604 WO2017032686A1 (en) 2015-08-21 2016-08-18 Method for the reduction of host cell proteins in affinity chromatography

Publications (2)

Publication Number Publication Date
MX2018001536A MX2018001536A (es) 2018-04-24
MX388197B true MX388197B (es) 2025-03-19

Family

ID=56802471

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001536A MX388197B (es) 2015-08-21 2016-08-18 Método para la reducción de proteínas de células hospederas en cromatografía de afinidad.

Country Status (14)

Country Link
US (2) US20180186832A1 (es)
EP (1) EP3337812B1 (es)
JP (4) JP6968055B2 (es)
KR (2) KR20240121902A (es)
CN (2) CN116063375A (es)
AU (1) AU2016312909B2 (es)
CA (1) CA2992420A1 (es)
ES (1) ES2877532T3 (es)
HR (1) HRP20211026T1 (es)
IL (1) IL257146B2 (es)
MX (1) MX388197B (es)
PL (1) PL3337812T3 (es)
SI (1) SI3337812T1 (es)
WO (1) WO2017032686A1 (es)

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Also Published As

Publication number Publication date
JP2018531895A (ja) 2018-11-01
HK1251584A1 (zh) 2019-02-01
CN116063375A (zh) 2023-05-05
WO2017032686A1 (en) 2017-03-02
CA2992420A1 (en) 2017-03-02
US20180186832A1 (en) 2018-07-05
IL257146B1 (en) 2024-09-01
KR20240121902A (ko) 2024-08-09
EP3337812A1 (en) 2018-06-27
MX2018001536A (es) 2018-04-24
JP6968055B2 (ja) 2021-11-17
HRP20211026T1 (hr) 2021-10-01
IL257146B2 (en) 2025-01-01
EP3337812B1 (en) 2021-04-28
SI3337812T1 (sl) 2021-08-31
ES2877532T3 (es) 2021-11-17
JP2025031829A (ja) 2025-03-07
KR102691585B1 (ko) 2024-08-05
JP7610638B2 (ja) 2025-01-08
AU2016312909B2 (en) 2022-12-08
BR112018001511A2 (pt) 2018-09-18
JP2023076617A (ja) 2023-06-01
JP2021176900A (ja) 2021-11-11
CN107849087A (zh) 2018-03-27
CN107849087B (zh) 2022-09-06
JP7258964B2 (ja) 2023-04-17
IL257146A (en) 2018-03-29
AU2016312909A1 (en) 2018-02-22
US12503487B2 (en) 2025-12-23
PL3337812T3 (pl) 2021-10-11
KR20180034500A (ko) 2018-04-04
US20220169675A1 (en) 2022-06-02

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