JP2014533928A - 癌を処置するためのｒｎａ操作ｔ細胞 - Google Patents

癌を処置するためのｒｎａ操作ｔ細胞 Download PDF

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JP2014533928A
JP2014533928A JP2014530925A JP2014530925A JP2014533928A JP 2014533928 A JP2014533928 A JP 2014533928A JP 2014530925 A JP2014530925 A JP 2014530925A JP 2014530925 A JP2014530925 A JP 2014530925A JP 2014533928 A JP2014533928 A JP 2014533928A
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seq
rna
cells
cancer
car
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JP2014533928A5 (cg-RX-API-DMAC7.html
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カール エイチ． ジューン
カール エイチ． ジューン
ヤンビン チャオ
ヤンビン チャオ
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4256—Tumor associated carbohydrates
    • A61K40/4258—Gangliosides, e.g. GM2, GD2 or GD3
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014530925A 2011-09-16 2012-09-17 癌を処置するためのｒｎａ操作ｔ細胞 Withdrawn JP2014533928A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535608P 2011-09-16 2011-09-16
US61/535,608 2011-09-16
PCT/US2012/055760 WO2013040557A2 (en) 2011-09-16 2012-09-17 Rna engineered t cells for the treatment of cancer

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JP2014533928A true JP2014533928A (ja) 2014-12-18
JP2014533928A5 JP2014533928A5 (cg-RX-API-DMAC7.html) 2015-11-05

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US (4) US10421960B2 (cg-RX-API-DMAC7.html)
EP (1) EP2756521A4 (cg-RX-API-DMAC7.html)
JP (1) JP2014533928A (cg-RX-API-DMAC7.html)
KR (1) KR20140060541A (cg-RX-API-DMAC7.html)
CN (1) CN103946952A (cg-RX-API-DMAC7.html)
AU (1) AU2012308205A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014006176A8 (cg-RX-API-DMAC7.html)
CA (1) CA2848410A1 (cg-RX-API-DMAC7.html)
EA (1) EA201490636A1 (cg-RX-API-DMAC7.html)
IL (1) IL231171A0 (cg-RX-API-DMAC7.html)
MX (1) MX2014003176A (cg-RX-API-DMAC7.html)
SG (1) SG11201400527XA (cg-RX-API-DMAC7.html)
WO (1) WO2013040557A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018519842A (ja) * 2015-07-21 2018-07-26 ノバルティス アーゲー 免疫細胞の有効性および増大を改善する方法
JP2022537154A (ja) * 2019-06-14 2022-08-24 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 細胞治療のための環状ｒｎａ

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