|
US4769320A
(en)
|
1982-07-27 |
1988-09-06 |
New England Medical Center Hospitals, Inc. |
Immunoassay means and methods useful in human native prothrombin and human abnormal prothorombin determinations
|
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
|
US4801687A
(en)
|
1986-10-27 |
1989-01-31 |
Bioprobe International, Inc. |
Monoclonal antibody purification process using protein A
|
|
US4851341A
(en)
|
1986-12-19 |
1989-07-25 |
Immunex Corporation |
Immunoaffinity purification system
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US4803247A
(en)
|
1987-10-27 |
1989-02-07 |
Allied-Signal Inc. |
Polyamide compositions having nitrile rubber and copolymer of ethylene and alpha-olefin therein
|
|
JPH01144991A
(ja)
|
1987-12-02 |
1989-06-07 |
Kagaku Oyobi Ketsusei Riyouhou Kenkyusho |
血液凝固第8因子の精製方法
|
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
AU665190B2
(en)
|
1990-07-10 |
1995-12-21 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
WO1992003918A1
(en)
|
1990-08-29 |
1992-03-19 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
HU218140B
(hu)
|
1991-04-25 |
2000-06-28 |
Chugai Seiyaku Kabushiki Kaisha |
Humán interleukin-6-receptorral szembeni átalakított humán antitest
|
|
ATE181571T1
(de)
|
1991-09-23 |
1999-07-15 |
Medical Res Council |
Methoden zur herstellung humanisierter antikörper
|
|
DE69233745D1
(de)
|
1991-12-02 |
2008-10-23 |
Cambridge Antibody Tech |
Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken
|
|
WO1993019172A1
(en)
|
1992-03-24 |
1993-09-30 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
NZ255101A
(en)
|
1992-07-24 |
1997-08-22 |
Cell Genesys Inc |
A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
CA2162497A1
(en)
|
1993-06-10 |
1994-12-22 |
Sheila Connelly |
Adenoviral vectors for treatment of hemophilia
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
GB9314271D0
(en)
|
1993-07-09 |
1993-08-18 |
Inst Of Cancer The Research |
Cell growth factor receptors
|
|
FR2707189B1
(fr)
|
1993-07-09 |
1995-10-13 |
Gradient Ass |
Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
|
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
|
EP0732404A4
(en)
|
1993-12-03 |
1997-07-30 |
Asahi Chemical Ind |
NEW EXPRESSION DETECTION VECTOR
|
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
EP0770628B9
(en)
|
1994-07-13 |
2007-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin-8
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
ES2384222T3
(es)
|
1994-10-07 |
2012-07-02 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibición del crecimiento anómalo de células sinoviales utilizando un antagonista de IL-6 como principio activo
|
|
PL182089B1
(en)
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
ATE390933T1
(de)
|
1995-04-27 |
2008-04-15 |
Amgen Fremont Inc |
Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
|
CZ399A3
(cs)
|
1996-07-19 |
1999-06-16 |
Amgen Inc. |
Polypeptidová analoga kationaktivních polypeptidů
|
|
CZ106299A3
(cs)
|
1996-09-26 |
1999-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
|
US5897781A
(en)
|
1997-06-06 |
1999-04-27 |
Waters Investments Limited |
Active pump phasing to enhance chromatographic reproducibility
|
|
AU750453B2
(en)
|
1997-10-03 |
2002-07-18 |
Chugai Seiyaku Kabushiki Kaisha |
Natural human antibody
|
|
SK14812000A3
(sk)
|
1998-04-03 |
2001-08-06 |
Chugai Seiyaku Kabushiki Kaisha |
Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
WO2000009560A2
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6475718B2
(en)
|
1998-09-08 |
2002-11-05 |
Schering Aktiengesellschaft |
Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
|
|
AU764211C
(en)
|
1998-12-01 |
2006-03-30 |
Abbvie Biotherapeutics Inc. |
Humanized antibodies to gamma-interferon
|
|
PL209786B1
(pl)
*
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
|
US7183387B1
(en)
*
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
PT1176195E
(pt)
|
1999-04-09 |
2013-07-18 |
Kyowa Hakko Kirin Co Ltd |
Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
|
MXPA02010801A
(es)
|
2000-05-03 |
2004-09-06 |
Munich Biotech Ag |
Agentes diagnosticos, de representacion y terapeuticos cationicos asociados con sitios vasculares activados.
|
|
NZ522700A
(en)
|
2000-06-16 |
2006-02-24 |
Human Genome Sciences Inc |
Antibodies that immunospecifically bind to blys
|
|
ES2335861T3
(es)
|
2000-09-08 |
2010-04-06 |
Universitat Zurich |
Grupos de proteinas repetitivas que comprenden modulos repetitivos.
|
|
EP3263702A1
(en)
|
2000-10-06 |
2018-01-03 |
Kyowa Hakko Kirin Co., Ltd. |
Cells producing antibody compositions
|
|
EP1356075A4
(en)
|
2000-10-16 |
2005-04-13 |
Compound Therapeutics Inc |
PROTEIN EQUIPMENT FOR ANTIBODY MIMETICS AND OTHER TIE PROTEINS
|
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
EP1383800A4
(en)
|
2001-04-02 |
2004-09-22 |
Idec Pharma Corp |
RECOMBINANT ANTIBODIES CO-EXPRESSED WITH GNTIII
|
|
US7358054B2
(en)
|
2001-04-13 |
2008-04-15 |
Biogen Idec Ma Inc. |
Antibodies to VLA-1
|
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
DK2208784T3
(da)
|
2001-06-22 |
2013-03-18 |
Chugai Pharmaceutical Co Ltd |
Celleproliferationsinhibitorer indeholdende anti-glypican-3-antistof
|
|
CA2447851C
(en)
|
2001-06-28 |
2012-08-28 |
Domantis Limited |
Dual-specific ligand and its use
|
|
US20040161741A1
(en)
|
2001-06-30 |
2004-08-19 |
Elazar Rabani |
Novel compositions and processes for analyte detection, quantification and amplification
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
RU2318829C2
(ru)
|
2001-11-14 |
2008-03-10 |
Сентокор, Инк. |
Антитела против il-6, композиции, способы и применение
|
|
EP1464702A4
(en)
|
2001-12-28 |
2005-09-21 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR PROTEIN STABILIZATION
|
|
US20030224397A1
(en)
|
2002-02-11 |
2003-12-04 |
Genentech, Inc. |
Antibody variants with faster antigen association rates
|
|
AR038568A1
(es)
|
2002-02-20 |
2005-01-19 |
Hoffmann La Roche |
Anticuerpos anti-a beta y su uso
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US8093357B2
(en)
|
2002-03-01 |
2012-01-10 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US20080199471A1
(en)
|
2002-03-01 |
2008-08-21 |
Bernett Matthew J |
Optimized cd40 antibodies and methods of using the same
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
EP1511861A4
(en)
|
2002-06-12 |
2007-12-05 |
Genencor Int |
METHODS AND BINDING COMPOSITIONS DEPENDENT FROM THE MEDIUM OF A TARGET AGENT TO A TARGET
|
|
WO2003107009A2
(en)
|
2002-06-12 |
2003-12-24 |
Genencor International, Inc. |
Methods for improving a binding characteristic of a molecule
|
|
US8193318B2
(en)
|
2002-08-14 |
2012-06-05 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
EP1539947A4
(en)
|
2002-08-15 |
2006-09-06 |
Epitomics Inc |
HUMANIZED RABBIT ANTIBODIES
|
|
RU2390527C2
(ru)
|
2002-09-27 |
2010-05-27 |
Ксенкор, Инк. |
АНТИТЕЛО, СОДЕРЖАЩЕЕ Fc-ВАРИАНТНУЮ ЧАСТЬ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТИТЕЛО, И СПОСОБ ЛЕЧЕНИЯ МЛЕКОПИТАЮЩЕГО
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
EP1562972B1
(en)
|
2002-10-15 |
2010-09-08 |
Facet Biotech Corporation |
ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
|
|
US7217798B2
(en)
|
2003-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of Fc-fusion protein serum half-lives by mutagenesis
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
AU2003290330A1
(en)
|
2002-12-27 |
2004-07-22 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
CA2515081A1
(en)
|
2003-02-07 |
2004-08-19 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
|
EP1601697B1
(en)
|
2003-02-28 |
2007-05-30 |
Lonza Biologics plc |
Antibody purification by Protein A and ion exchange chromatography
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
CA2766627C
(en)
|
2003-05-02 |
2019-12-03 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
BRPI0411276A
(pt)
|
2003-06-05 |
2006-08-01 |
Genentech Inc |
métodos de esgotamento de células b, método de tratamento de neoplasma de células b ou malignidade, método de alìvio de disfunção autoimunológica regulada por células b, composição e artigo industrializado
|
|
EP2239271A1
(en)
|
2003-06-13 |
2010-10-13 |
Biogen Idec MA Inc. |
Aglycosyl anti-CD154 (CD40 ligand) antibodies and uses thereof
|
|
AU2004273791A1
(en)
|
2003-09-05 |
2005-03-31 |
Genentech, Inc. |
Antibodies with altered effector functions
|
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
WO2005035753A1
(ja)
|
2003-10-10 |
2005-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
機能蛋白質を代替する二重特異性抗体
|
|
EP1675878A2
(en)
|
2003-10-24 |
2006-07-05 |
Avidia, Inc. |
Ldl receptor class a and egf domain monomers and multimers
|
|
ES2285543T3
(es)
|
2003-11-05 |
2007-11-16 |
Ares Trading S.A. |
Procedimiento para la purificacion de la proteina de union a il-18.
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
AU2004299833B2
(en)
|
2003-12-10 |
2009-05-07 |
E. R. Squibb & Sons, L.L.C. |
Interferon alpha antibodies and their uses
|
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
PL2177537T3
(pl)
|
2004-01-09 |
2012-06-29 |
Pfizer |
Przeciwciała przeciw MadCAM
|
|
PL1706424T3
(pl)
|
2004-01-12 |
2010-04-30 |
Mentrik Biotech Llc |
Warianty regionu Fc
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
US20050260711A1
(en)
|
2004-03-30 |
2005-11-24 |
Deepshikha Datta |
Modulating pH-sensitive binding using non-natural amino acids
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
WO2005115452A2
(en)
|
2004-04-16 |
2005-12-08 |
Macrogenics, Inc. |
Fcϝriib-specific antibodies and methods of use thereof
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
CA2568952C
(en)
|
2004-06-18 |
2019-05-21 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
|
WO2006004663A2
(en)
|
2004-06-25 |
2006-01-12 |
Medimmune, Inc. |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
|
DE102004032634A1
(de)
|
2004-07-06 |
2006-02-16 |
Sms Demag Ag |
Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
|
|
CA2565961A1
(en)
|
2004-07-15 |
2006-02-23 |
Xencor, Inc. |
Optimized fc variants
|
|
AU2005274905B2
(en)
|
2004-08-04 |
2010-12-23 |
Mentrik Biotech, Llc |
Variant Fc regions
|
|
EP1787998A4
(en)
|
2004-08-11 |
2008-08-27 |
Mitsubishi Chem Corp |
ANTIBODIES AND THEIR USE
|
|
EP1784424A4
(en)
|
2004-08-16 |
2009-03-18 |
Medimmune Inc |
EPH RECEPTOR BINDING FC VARIANTS HAVING CELLULAR CELLULAR ACTIVITY DEPENDENT ANTIBODIES
|
|
WO2006031370A2
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
CA2580319A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
EP1812068A4
(en)
|
2004-10-29 |
2010-06-09 |
Medimmune Inc |
METHODS FOR PREVENTING AND TREATING RSV INFECTIONS AND ASSOCIATED DISEASES
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
RU2412200C2
(ru)
|
2004-11-12 |
2011-02-20 |
Ксенкор, Инк. |
Fc-ВАРИАНТЫ С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ С FcRn
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
CA2587617C
(en)
|
2004-11-12 |
2011-02-01 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
|
WO2006067847A1
(ja)
|
2004-12-22 |
2006-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
|
|
KR20070115871A
(ko)
|
2004-12-23 |
2007-12-06 |
노보 노르디스크 에이/에스 |
항체 결합 친화 리간드
|
|
EP1871808A2
(en)
|
2005-03-31 |
2008-01-02 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
|
JP5620626B2
(ja)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
|
DK1876236T3
(da)
|
2005-04-08 |
2014-10-20 |
Chugai Pharmaceutical Co Ltd |
Antistof som funktionel erstatning for blodkoagulationsfaktor VIII
|
|
WO2006116260A2
(en)
|
2005-04-26 |
2006-11-02 |
Medimmune, Inc. |
Modulation of antibody effector function by hinge domain engineering
|
|
EP1885755A4
(en)
|
2005-05-05 |
2009-07-29 |
Univ Duke |
CD19 ANTIBODY THERAPY FOR AUTOIMMUNE DISEASES
|
|
ES2523666T3
(es)
|
2005-05-31 |
2014-11-28 |
Board Of Regents, The University Of Texas System |
Anticuerpos IgG1 con la parte Fc mutada para el aumento de unión al receptor FcRn y usos de los mismos
|
|
ES2526811T3
(es)
|
2005-08-10 |
2015-01-15 |
Macrogenics, Inc. |
Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de uso de estos
|
|
MX2008002367A
(es)
|
2005-08-19 |
2008-03-18 |
Wyeth Corp |
Anticuerpos antagonistas contra el factor 8 de crecimiento y diferenciacion y usos en el tratamiento de esclerosis lateral amiotrofica y otros trastornos relacionados con el factor 8 de crecimiento y diferenciacion.
|
|
DK1931709T3
(en)
|
2005-10-03 |
2017-03-13 |
Xencor Inc |
FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
|
|
ES2577292T3
(es)
|
2005-11-07 |
2016-07-14 |
Genentech, Inc. |
Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
JP2009519236A
(ja)
|
2005-11-30 |
2009-05-14 |
キャン−ファイト・バイオファーマ・リミテッド |
A3アデノシンレセプター抗体の治療的使用
|
|
DK2548577T3
(en)
|
2005-12-29 |
2017-03-13 |
Janssen Biotech Inc |
HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, PROCEDURES AND APPLICATIONS
|
|
US20080071063A1
(en)
|
2006-02-03 |
2008-03-20 |
Medimmune, Inc. |
Protein Formulations
|
|
EP4218801A3
(en)
|
2006-03-31 |
2023-08-23 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
|
CA2647846C
(en)
|
2006-03-31 |
2016-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
|
EP2021029B1
(en)
|
2006-05-26 |
2014-06-11 |
MacroGenics, Inc. |
Humanized fc gamma riib-specific antibodies and methods of use thereof
|
|
CA2654623C
(en)
|
2006-06-08 |
2016-07-26 |
Chugai Seiyaku Kabushiki Kaisha |
An anti-nr10/il-31ra antibody for use in preventing or treating an inflammatory disease
|
|
EP2032159B1
(en)
|
2006-06-26 |
2015-01-07 |
MacroGenics, Inc. |
Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
|
|
AU2007285976B2
(en)
|
2006-08-14 |
2011-08-18 |
Xencor, Inc |
Optimized antibodies that target CD19
|
|
US8236313B2
(en)
|
2006-10-06 |
2012-08-07 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Prevention of tissue ischemia, related methods and compositions
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
US8652466B2
(en)
|
2006-12-08 |
2014-02-18 |
Macrogenics, Inc. |
Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
|
|
SI2436696T1
(sl)
|
2007-01-05 |
2017-10-30 |
University Of Zurich |
Anti-beta-amiloidno protitelo in načini njegove uporabe
|
|
JP5357778B2
(ja)
|
2007-01-23 |
2013-12-04 |
ゼンコー・インコーポレイテッド |
最適化cd40抗体および前記を使用する方法
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
EP2087111A2
(en)
|
2007-03-19 |
2009-08-12 |
Medimmune Limited |
Polypeptide variants
|
|
EP2144931A2
(en)
|
2007-04-04 |
2010-01-20 |
The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services |
Monoclonal antibodies against dengue and other viruses with deletion in fc region
|
|
MX2009012343A
(es)
|
2007-05-14 |
2010-02-10 |
Biogen Idec Inc |
Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello.
|
|
DK2176298T3
(en)
|
2007-05-30 |
2018-02-12 |
Xencor Inc |
Methods and compositions for inhibiting CD32B-expressing cells
|
|
JP5517931B2
(ja)
|
2007-06-29 |
2014-06-11 |
クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド |
液体クロマトグラフィー質量分析による体液中のアミノ酸分析
|
|
EP2189526B1
(en)
|
2007-07-06 |
2013-09-04 |
Tokyo Metropolitan Institute of Medical Science |
Antibody binding specifically to tdp-43 aggregate
|
|
PL2202245T3
(pl)
|
2007-09-26 |
2017-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr
|
|
BRPI0817250A2
(pt)
|
2007-09-26 |
2014-06-17 |
Chugai Pharmaceutical Co Ltd |
Anticorpo anti-receptor da il-6.
|
|
WO2009041613A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗体定常領域改変体
|
|
MY148637A
(en)
|
2007-09-28 |
2013-05-15 |
Chugai Pharmaceutical Co Ltd |
Anti-glypican-3 antibody having improved kinetics in plasma
|
|
JP2011500756A
(ja)
|
2007-10-22 |
2011-01-06 |
メルク セローノ ソシエテ アノニム |
Fc融合タンパク質を精製する方法
|
|
WO2009062051A2
(en)
|
2007-11-08 |
2009-05-14 |
Pikamab, Inc. |
Methods and compositions for antibody therapy
|
|
EP2261254A3
(en)
|
2007-12-21 |
2011-04-13 |
Amgen, Inc |
Anti-amyloid antibodies and uses thereof
|
|
DK2808343T3
(da)
|
2007-12-26 |
2019-08-19 |
Xencor Inc |
Fc-varianter med ændret binding til FcRn
|
|
JP5373823B2
(ja)
|
2008-01-29 |
2013-12-18 |
アブリンクス エン.ヴェー. |
タンパク質及びポリペプチドを安定化する方法
|
|
KR102269708B1
(ko)
|
2008-04-11 |
2021-06-25 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
JP2011519279A
(ja)
|
2008-05-01 |
2011-07-07 |
アムジエン・インコーポレーテツド |
抗ヘプシジン抗体及び使用の方法
|
|
CN102625813A
(zh)
|
2008-06-20 |
2012-08-01 |
诺华公司 |
具有降低的聚集的免疫球蛋白
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
JP5028372B2
(ja)
|
2008-09-26 |
2012-09-19 |
京セラドキュメントソリューションズ株式会社 |
画像処理装置、画像処理方法及び画像処理プログラム
|
|
PL2352521T3
(pl)
|
2008-10-14 |
2021-03-08 |
Genentech, Inc. |
Warianty immunoglobuliny i ich zastosowania
|
|
JP5807300B2
(ja)
|
2008-11-18 |
2015-11-10 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
|
BRPI1006141B8
(pt)
|
2009-01-12 |
2021-05-25 |
Cytomx Therapeutics Llc |
composições de anticorpo modificado, métodos para preparar e usar as mesmas
|
|
JP2012515556A
(ja)
|
2009-01-23 |
2012-07-12 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
低下したエフェクタ機能を有する安定化Fcポリペプチドおよび使用方法
|
|
EP2400981A4
(en)
|
2009-02-26 |
2013-02-27 |
Lpath Inc |
DESGIN FOR HUMANIZED THROMBOZYTE ACTIVATION FACTOR ANTIBODIES BY ANTI-LIPID ANTIBODY TEMPLATES
|
|
US20120071634A1
(en)
|
2009-03-19 |
2012-03-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody Constant Region Variant
|
|
EP2233500A1
(en)
*
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
AU2010201495B2
(en)
|
2009-04-16 |
2012-04-12 |
Accenture Global Services Limited |
Touchpoint customization system
|
|
US8568726B2
(en)
*
|
2009-10-06 |
2013-10-29 |
Medimmune Limited |
RSV specific binding molecule
|
|
NZ599148A
(en)
|
2009-10-06 |
2014-08-29 |
Medimmune Ltd |
Rsv-specific binding molecule
|
|
BR112012007760A2
(pt)
*
|
2009-10-07 |
2015-08-25 |
Macrogenics Inc |
Método de atenuar fucosilação pós translacional de uma região fc de igc humana, anticorpo que se liga especificamente a um antigeno de câncer caracteristico de um cancêr polipeptideo
|
|
WO2011094593A2
(en)
|
2010-01-28 |
2011-08-04 |
Ab Biosciences, Inc. |
Novel lowered affinity antibodies and methods of marking the same
|
|
PT3053932T
(pt)
|
2010-02-19 |
2020-10-21 |
Xencor Inc |
Novas imunoadesinas ctla4-ig
|
|
AU2011225716A1
(en)
|
2010-03-11 |
2012-09-27 |
Pfizer Inc. |
Antibodies with pH dependent antigen binding
|
|
JP2011184418A
(ja)
|
2010-03-11 |
2011-09-22 |
Tokyo Institute Of Technology |
親和性可変抗体
|
|
TWI667346B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
JP6121904B2
(ja)
|
2010-09-08 |
2017-04-26 |
ハロザイム インコーポレイテッド |
条件的活性治療用タンパク質を評価および同定する、または発展させる方法
|
|
EP4231014A3
(en)
|
2010-11-30 |
2024-08-14 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
WO2012133782A1
(ja)
*
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
|
KR20230005405A
(ko)
|
2011-02-25 |
2023-01-09 |
추가이 세이야쿠 가부시키가이샤 |
FcγRIIb 특이적 Fc 항체
|
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
|
JP2014517846A
(ja)
|
2011-05-25 |
2014-07-24 |
メルク・シャープ・アンド・ドーム・コーポレーション |
改善された特性を有するFc含有ポリペプチドの製造方法
|
|
UA117901C2
(uk)
*
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP3778889A1
(en)
*
|
2011-09-30 |
2021-02-17 |
Chugai Seiyaku Kabushiki Kaisha |
Ion concentration-dependent binding molecule library
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
TWI580693B
(zh)
|
2011-09-30 |
2017-05-01 |
中外製藥股份有限公司 |
促進抗原消失的抗原結合分子
|
|
TW201326209A
(zh)
*
|
2011-09-30 |
2013-07-01 |
Chugai Pharmaceutical Co Ltd |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
TWI681970B
(zh)
|
2011-09-30 |
2020-01-11 |
日商中外製藥股份有限公司 |
包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子
|
|
US20150299313A1
(en)
|
2011-10-05 |
2015-10-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain
|
|
RU2739792C1
(ru)
|
2011-11-30 |
2020-12-28 |
Чугаи Сейяку Кабусики Кайся |
Содержащий лекарственное средство переносчик в клетку для формирования иммунного комплекса
|
|
CN113480639A
(zh)
|
2012-02-09 |
2021-10-08 |
中外制药株式会社 |
抗体的Fc区变异体
|
|
BR112014020821B1
(pt)
|
2012-02-24 |
2022-11-16 |
Chugai Seiyaku Kabushiki Kaisha |
Composição farmacêutica e método de produção de uma molécula de ligação a antígeno
|
|
US20150353630A1
(en)
|
2012-05-30 |
2015-12-10 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for eliminating aggregated antigens
|
|
CN107964042B
(zh)
|
2012-05-30 |
2022-04-19 |
中外制药株式会社 |
靶组织特异性抗原结合分子
|
|
KR20150041662A
(ko)
|
2012-08-13 |
2015-04-16 |
리제너론 파아마슈티컬스, 인크. |
Ph-의존적 결합 특성을 갖는 항-pcsk9 항체
|
|
SG10201709559PA
(en)
|
2012-08-24 |
2017-12-28 |
Chugai Pharmaceutical Co Ltd |
Fcγriib-specific fc region variant
|
|
EP2889376A4
(en)
|
2012-08-24 |
2016-11-02 |
Chugai Pharmaceutical Co Ltd |
ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE
|
|
TW201418707A
(zh)
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分c5拮抗劑之篩選分析
|
|
BR112015018438A2
(pt)
|
2013-01-31 |
2017-07-18 |
Seoul Nat Univ R&Db Foundation |
anticorpo contra c5 e método para prevenir e tratar doenças relacionadas a complemento
|
|
US9321686B2
(en)
|
2013-03-15 |
2016-04-26 |
Forta Corporation |
Reinforcement fiber coating compositions, methods of making and treating, and uses for improved adhesion to asphalt and portland cement concrete
|
|
EP2968985A2
(en)
|
2013-03-15 |
2016-01-20 |
Amgen, Inc. |
Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
|
|
CN105246914B
(zh)
|
2013-04-02 |
2021-08-27 |
中外制药株式会社 |
Fc区变体
|
|
NZ711451A
(en)
|
2014-03-07 |
2016-05-27 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
|
US10183994B2
(en)
|
2014-06-30 |
2019-01-22 |
Merck Patent Gmbh |
Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearence
|
|
JP6174782B2
(ja)
*
|
2014-12-19 |
2017-08-02 |
中外製薬株式会社 |
抗c5抗体および使用方法
|
|
CN107108729A
(zh)
*
|
2015-02-05 |
2017-08-29 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il‑8‑结合抗体,及其应用
|