JP2014506601A5 - - Google Patents
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- JP2014506601A5 JP2014506601A5 JP2013555580A JP2013555580A JP2014506601A5 JP 2014506601 A5 JP2014506601 A5 JP 2014506601A5 JP 2013555580 A JP2013555580 A JP 2013555580A JP 2013555580 A JP2013555580 A JP 2013555580A JP 2014506601 A5 JP2014506601 A5 JP 2014506601A5
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- JP
- Japan
- Prior art keywords
- item
- alkyl
- halo
- heterocycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 53
- 150000003839 salts Chemical class 0.000 claims description 11
- 206010012601 diabetes mellitus Diseases 0.000 claims description 8
- 201000004681 Psoriasis Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 201000004624 Dermatitis Diseases 0.000 claims description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 3
- 206010014561 Emphysema Diseases 0.000 claims description 3
- 208000032612 Glial tumor Diseases 0.000 claims description 3
- 206010018338 Glioma Diseases 0.000 claims description 3
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 3
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 3
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010033645 Pancreatitis Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 3
- 206010039710 Scleroderma Diseases 0.000 claims description 3
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 3
- 208000026935 allergic disease Diseases 0.000 claims description 3
- 230000007815 allergy Effects 0.000 claims description 3
- 230000036783 anaphylactic response Effects 0.000 claims description 3
- 208000003455 anaphylaxis Diseases 0.000 claims description 3
- 208000010668 atopic eczema Diseases 0.000 claims description 3
- 206010006451 bronchitis Diseases 0.000 claims description 3
- 201000000493 colon squamous cell carcinoma Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 208000024908 graft versus host disease Diseases 0.000 claims description 3
- 201000011066 hemangioma Diseases 0.000 claims description 3
- 208000017169 kidney disease Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 206010025135 lupus erythematosus Diseases 0.000 claims description 3
- 208000002780 macular degeneration Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 208000037803 restenosis Diseases 0.000 claims description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
- 208000012972 squamous cell carcinoma of colon Diseases 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 description 81
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 76
- -1 heterocycloalkyloxy Chemical class 0.000 description 66
- 125000000217 alkyl group Chemical group 0.000 description 44
- 125000005843 halogen group Chemical group 0.000 description 40
- 125000003118 aryl group Chemical group 0.000 description 38
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 38
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 38
- 125000001072 heteroaryl group Chemical group 0.000 description 37
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 36
- 229910019142 PO4 Inorganic materials 0.000 description 36
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 36
- 125000002252 acyl group Chemical group 0.000 description 36
- 125000004423 acyloxy group Chemical group 0.000 description 36
- 125000003342 alkenyl group Chemical group 0.000 description 36
- 125000003545 alkoxy group Chemical group 0.000 description 36
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 36
- 125000000304 alkynyl group Chemical group 0.000 description 36
- 150000001408 amides Chemical class 0.000 description 36
- 125000003710 aryl alkyl group Chemical group 0.000 description 36
- 239000004202 carbamide Substances 0.000 description 36
- 125000004122 cyclic group Chemical group 0.000 description 36
- 125000000753 cycloalkyl group Chemical group 0.000 description 36
- 125000004404 heteroalkyl group Chemical group 0.000 description 36
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 36
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 36
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 36
- 239000010452 phosphate Substances 0.000 description 36
- 229940124530 sulfonamide Drugs 0.000 description 36
- 150000003456 sulfonamides Chemical class 0.000 description 36
- 229910052739 hydrogen Inorganic materials 0.000 description 30
- 239000001257 hydrogen Substances 0.000 description 30
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 30
- 0 *c1c2nc(N)[o]c2c(*)c(*)c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O Chemical compound *c1c2nc(N)[o]c2c(*)c(*)c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 10
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 9
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 229910052717 sulfur Inorganic materials 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 201000008171 proliferative glomerulonephritis Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QQESVQNMQDZQHT-UHFFFAOYSA-N CN(C1)CC(C2)C1CN2C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CN(C1)CC(C2)C1CN2C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O QQESVQNMQDZQHT-UHFFFAOYSA-N 0.000 description 1
- MXAVXHBXUHXKAM-UHFFFAOYSA-N CN(CC1)CCN1c1nnc(cc2)[n]1cc2-c(cc1)cc2c1nc(N)[o]2 Chemical compound CN(CC1)CCN1c1nnc(cc2)[n]1cc2-c(cc1)cc2c1nc(N)[o]2 MXAVXHBXUHXKAM-UHFFFAOYSA-N 0.000 description 1
- JFQKQWJUCNSORA-UHFFFAOYSA-N CN1CCN(CCc2nnc(cc3)[n]2cc3-c(cc2)cc3c2nc(N)[o]3)CC1 Chemical compound CN1CCN(CCc2nnc(cc3)[n]2cc3-c(cc2)cc3c2nc(N)[o]3)CC1 JFQKQWJUCNSORA-UHFFFAOYSA-N 0.000 description 1
- IPGGRBSJXVRDMH-UHFFFAOYSA-N CN1CCN(Cc2nnc(cc3)[n]2cc3-c(cc2)cc3c2nc(N)[o]3)CC1 Chemical compound CN1CCN(Cc2nnc(cc3)[n]2cc3-c(cc2)cc3c2nc(N)[o]3)CC1 IPGGRBSJXVRDMH-UHFFFAOYSA-N 0.000 description 1
- FROLFXUNNJXSCM-UHFFFAOYSA-N C[n]1ncc2c1cncc2-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O Chemical compound C[n]1ncc2c1cncc2-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O FROLFXUNNJXSCM-UHFFFAOYSA-N 0.000 description 1
- SSUJNFTULPBNSD-UHFFFAOYSA-N Cc(nc1)c2[nH]ccc2c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O Chemical compound Cc(nc1)c2[nH]ccc2c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O SSUJNFTULPBNSD-UHFFFAOYSA-N 0.000 description 1
- NOFBWFALVUWQFU-UHFFFAOYSA-N Cc(nc1)c2[nH]ncc2c1-c(cc1)c[n]2c1ncc2C(N1C2COCC1CC2)=O Chemical compound Cc(nc1)c2[nH]ncc2c1-c(cc1)c[n]2c1ncc2C(N1C2COCC1CC2)=O NOFBWFALVUWQFU-UHFFFAOYSA-N 0.000 description 1
- GCQBQPXYJIEDOP-UHFFFAOYSA-N Cc(nc1)c2[nH]ncc2c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O Chemical compound Cc(nc1)c2[nH]ncc2c1-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O GCQBQPXYJIEDOP-UHFFFAOYSA-N 0.000 description 1
- MSXFZTVVGNYKDM-UHFFFAOYSA-N Cc1cc(-c(cc2)cc3c2nc(N)[o]3)c[n]2c(-c3ccncc3)nnc12 Chemical compound Cc1cc(-c(cc2)cc3c2nc(N)[o]3)c[n]2c(-c3ccncc3)nnc12 MSXFZTVVGNYKDM-UHFFFAOYSA-N 0.000 description 1
- JZDCENLTEHAJLS-UHFFFAOYSA-N Nc1nc(cc(cc2)-c3cnc(cc4)[n]3cc4C(N3CCOCC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c3cnc(cc4)[n]3cc4C(N3CCOCC3)=O)c2[o]1 JZDCENLTEHAJLS-UHFFFAOYSA-N 0.000 description 1
- BSPHZKKRWHTGAQ-UHFFFAOYSA-N Nc1nc(ccc(-c(cc2)c[n]3c2ncc3C(N2CCOCC2)=O)c2)c2[nH]1 Chemical compound Nc1nc(ccc(-c(cc2)c[n]3c2ncc3C(N2CCOCC2)=O)c2)c2[nH]1 BSPHZKKRWHTGAQ-UHFFFAOYSA-N 0.000 description 1
- WVSALGROVPJFFB-UHFFFAOYSA-N Nc1nc2cc(-c3cnc(cc4)[n]3cc4C(N3C4COCC3CC4)=O)ccc2[o]1 Chemical compound Nc1nc2cc(-c3cnc(cc4)[n]3cc4C(N3C4COCC3CC4)=O)ccc2[o]1 WVSALGROVPJFFB-UHFFFAOYSA-N 0.000 description 1
- OMMRCYUMEZEGJN-UHFFFAOYSA-N O=C(c1cnc(cc2)[n]1cc2-c1cc([nH]cc2)c2nc1)N1CCOCC1 Chemical compound O=C(c1cnc(cc2)[n]1cc2-c1cc([nH]cc2)c2nc1)N1CCOCC1 OMMRCYUMEZEGJN-UHFFFAOYSA-N 0.000 description 1
- OEFNXIPQCPFMDJ-UHFFFAOYSA-N O=C(c1cnc(cc2)[n]1cc2-c1ccnc2c1cn[nH]2)N1CCOCC1 Chemical compound O=C(c1cnc(cc2)[n]1cc2-c1ccnc2c1cn[nH]2)N1CCOCC1 OEFNXIPQCPFMDJ-UHFFFAOYSA-N 0.000 description 1
- HGTBLURUMIBMAP-UHFFFAOYSA-N O=C(c1cnc(cc2)[n]1cc2-c1cnc(cn[nH]2)c2c1)N1CCOCC1 Chemical compound O=C(c1cnc(cc2)[n]1cc2-c1cnc(cn[nH]2)c2c1)N1CCOCC1 HGTBLURUMIBMAP-UHFFFAOYSA-N 0.000 description 1
- VXMPYADDRAZEHW-UHFFFAOYSA-N OCC[n]1ncc2c1cncc2-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O Chemical compound OCC[n]1ncc2c1cncc2-c(cc1)c[n]2c1ncc2C(N1CCOCC1)=O VXMPYADDRAZEHW-UHFFFAOYSA-N 0.000 description 1
- 108091007960 PI3Ks Proteins 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 201000004240 prostatic hypertrophy Diseases 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161445999P | 2011-02-23 | 2011-02-23 | |
| US61/445,999 | 2011-02-23 | ||
| PCT/US2012/026406 WO2012116237A2 (en) | 2011-02-23 | 2012-02-23 | Heterocyclic compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506601A JP2014506601A (ja) | 2014-03-17 |
| JP2014506601A5 true JP2014506601A5 (enExample) | 2015-07-02 |
| JP5808826B2 JP5808826B2 (ja) | 2015-11-10 |
Family
ID=46721464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555580A Expired - Fee Related JP5808826B2 (ja) | 2011-02-23 | 2012-02-23 | 複素環化合物およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9127000B2 (enExample) |
| EP (1) | EP2678016B1 (enExample) |
| JP (1) | JP5808826B2 (enExample) |
| WO (1) | WO2012116237A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| ES2689429T3 (es) | 2012-07-13 | 2018-11-14 | Ucb Biopharma Sprl | Derivados de imidazopiridina como moduladores de actividad de TNF |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| JP6434416B2 (ja) | 2012-11-08 | 2018-12-05 | ライゼン・ファーマシューティカルズ・エスアー | ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR102469849B1 (ko) | 2013-04-19 | 2022-11-23 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| WO2015123408A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| TWI664164B (zh) | 2014-02-13 | 2019-07-01 | 美商英塞特控股公司 | 作為ｌｓｄ１抑制劑之環丙胺 |
| PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
| US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| CN105503877A (zh) * | 2014-09-24 | 2016-04-20 | 和记黄埔医药（上海）有限公司 | 咪唑并哒嗪类化合物及其用途 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| WO2016073891A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| KR102662215B1 (ko) | 2014-11-06 | 2024-05-02 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도 |
| JP6568588B2 (ja) | 2014-12-19 | 2019-08-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ＰＩ３Ｋβ阻害剤としてのイミダゾピリダジン誘導体 |
| SI3233839T1 (sl) | 2014-12-19 | 2019-12-31 | Janssen Pharmaceutica Nv | Heterociklil vezani derivati imidazopiridazina kot inhibitorji PI3Kbeta |
| JP6385584B2 (ja) | 2014-12-24 | 2018-09-05 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖの処置のための縮合ピリミジン化合物 |
| TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| PT3237397T (pt) | 2014-12-24 | 2019-02-08 | Gilead Sciences Inc | Compostos de isoquinolina para o tratamento de hiv |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MY191796A (en) | 2015-04-03 | 2022-07-15 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
| HK1255074A1 (zh) | 2015-07-01 | 2019-08-02 | Crinetics Pharmaceuticals, Inc. | 生长抑素调节剂及其用途 |
| KR102710120B1 (ko) | 2015-08-12 | 2024-09-27 | 인사이트 홀딩스 코포레이션 | Lsd1 저해제의 염 |
| CN105130984B (zh) * | 2015-09-23 | 2017-03-29 | 前湾医药科技（深圳）有限公司 | 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用 |
| JP6912460B2 (ja) | 2015-10-09 | 2021-08-04 | ヤンセン ファーマシューティカ エヌ．ベー． | ＰＩ３Ｋβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体 |
| PT3436461T (pt) | 2016-03-28 | 2024-01-23 | Incyte Corp | Compostos de pirrolotriazina como inibidores de tam |
| US11192892B2 (en) | 2016-04-06 | 2021-12-07 | Bial—R&D Investments, S.A. | Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders |
| JP7034935B2 (ja) | 2016-04-06 | 2022-03-14 | リソソーマル・セラピューティクス・インコーポレイテッド | ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| PE20190377A1 (es) | 2016-04-22 | 2019-03-08 | Incyte Corp | Formulaciones de un inhibidor de lsd 1 |
| WO2017192930A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| JP7149854B2 (ja) | 2016-06-16 | 2022-10-07 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｐｉ３ｋ ｂｅｔａ阻害薬としての二環式ピリジン、ピラジンおよびピリミジン誘導体 |
| ES2818620T3 (es) | 2016-06-16 | 2021-04-13 | Janssen Pharmaceutica Nv | Derivados de azabencimidazol como inhibidores de pi3k beta |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| AU2017296289A1 (en) | 2016-07-12 | 2019-01-31 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| CN110431134A (zh) | 2017-01-23 | 2019-11-08 | 锐新医药公司 | 作为变构shp2抑制剂的吡啶化合物 |
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2012
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- 2012-02-23 JP JP2013555580A patent/JP5808826B2/ja not_active Expired - Fee Related
- 2012-02-23 WO PCT/US2012/026406 patent/WO2012116237A2/en not_active Ceased
- 2012-02-23 US US14/001,143 patent/US9127000B2/en not_active Expired - Fee Related
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