JP2014505735A5 - - Google Patents
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- JP2014505735A5 JP2014505735A5 JP2013554626A JP2013554626A JP2014505735A5 JP 2014505735 A5 JP2014505735 A5 JP 2014505735A5 JP 2013554626 A JP2013554626 A JP 2013554626A JP 2013554626 A JP2013554626 A JP 2013554626A JP 2014505735 A5 JP2014505735 A5 JP 2014505735A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- formula
- compound
- mtor inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 229940124302 mTOR inhibitor Drugs 0.000 claims 15
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 206010028537 myelofibrosis Diseases 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 6
- 239000002552 dosage form Substances 0.000 claims 6
- 208000003476 primary myelofibrosis Diseases 0.000 claims 6
- 230000002062 proliferating effect Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- MFAQYJIYDMLAIM-UHFFFAOYSA-N torkinib Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC2=CC(O)=CC=C2N1 MFAQYJIYDMLAIM-UHFFFAOYSA-N 0.000 claims 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 4
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 4
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical group C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- -1 7H-pyrrolo [2,3-d] pyrimidin-4-yl Chemical group 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims 2
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 2
- 208000033755 Neutrophilic Chronic Leukemia Diseases 0.000 claims 2
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims 2
- 208000021668 chronic eosinophilic leukemia Diseases 0.000 claims 2
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 2
- 201000010903 chronic neutrophilic leukemia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 101100480622 Caenorhabditis elegans tat-5 gene Proteins 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000027405 negative regulation of phosphorylation Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444581P | 2011-02-18 | 2011-02-18 | |
| US61/444,581 | 2011-02-18 | ||
| US201161503789P | 2011-07-01 | 2011-07-01 | |
| US201161503785P | 2011-07-01 | 2011-07-01 | |
| US61/503,789 | 2011-07-01 | ||
| US61/503,785 | 2011-07-01 | ||
| PCT/US2012/025581 WO2012112847A1 (en) | 2011-02-18 | 2012-02-17 | mTOR/JAK INHIBITOR COMBINATION THERAPY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505735A JP2014505735A (ja) | 2014-03-06 |
| JP2014505735A5 true JP2014505735A5 (enExample) | 2015-03-12 |
| JP5936628B2 JP5936628B2 (ja) | 2016-06-22 |
Family
ID=45755586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554626A Active JP5936628B2 (ja) | 2011-02-18 | 2012-02-17 | ｍＴＯＲ／ＪＡＫ阻害剤併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9993480B2 (enExample) |
| EP (1) | EP2675451B9 (enExample) |
| JP (1) | JP5936628B2 (enExample) |
| KR (1) | KR102024948B1 (enExample) |
| CN (1) | CN103732226B (enExample) |
| AU (1) | AU2012219395B2 (enExample) |
| BR (1) | BR112013020798B1 (enExample) |
| CA (1) | CA2827673C (enExample) |
| EA (1) | EA026317B1 (enExample) |
| ES (1) | ES2547916T3 (enExample) |
| MX (1) | MX357939B (enExample) |
| PL (1) | PL2675451T3 (enExample) |
| PT (1) | PT2675451E (enExample) |
| WO (1) | WO2012112847A1 (enExample) |
Families Citing this family (49)
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| KR101391900B1 (ko) * | 2005-12-13 | 2014-05-02 | 인사이트 코포레이션 | 야누스 키나아제 억제제로서의 헤테로아릴 치환된 피롤로［2,3-ｂ］피리딘 및 피롤로［2,3-ｂ］피리미딘 |
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| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| TW201100429A (en) | 2009-05-22 | 2011-01-01 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PH12015502575A1 (en) * | 2010-03-10 | 2017-04-24 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| EP3087972A1 (en) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
| CA2818545C (en) | 2010-11-19 | 2019-04-16 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
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| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
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| EP3949953A1 (en) | 2012-11-15 | 2022-02-09 | Incyte Holdings Corporation | Sustained-release dosage forms of ruxolitinib |
| BR112015021458B1 (pt) | 2013-03-06 | 2022-06-07 | Incyte Holdings Corporation | "processos e intermediários para preparar {1-{1-[3-flúor2-(trifluormetil)isonicotinoil] piperidin-4-il}-3-[4-(7hpirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrila, útil no tratamento de doenças relacionadas com a atividade de janus quinases |
| EP2994119A1 (en) * | 2013-05-10 | 2016-03-16 | CNIC Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III | Compounds suitable for the treatment of myeloproliferative neoplasms |
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| CR20160553A (es) | 2014-04-30 | 2017-04-25 | Incyte Corp | Procesos para preparar un inhibidor de jak1 y nuevas formas de este |
| KR20160145833A (ko) * | 2014-05-02 | 2016-12-20 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 사용한 급성 골수성 백혈병 및/또는 급성 림프아구성 백혈병의 치료 방법 |
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| EP3775284A1 (en) | 2018-03-30 | 2021-02-17 | Incyte Corporation | Biomarkers for inflammatory skin disease |
| CN112423759A (zh) | 2018-03-30 | 2021-02-26 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
| MX2020010815A (es) | 2018-04-13 | 2020-12-11 | Incyte Corp | Biomarcadores para enfermedad de injerto contra hospedero. |
| EA202191170A1 (ru) | 2018-10-31 | 2021-07-27 | Инсайт Корпорейшн | Комбинированная терапия для лечения гематологических заболеваний |
| WO2021013942A1 (en) * | 2019-07-24 | 2021-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of myeloperoxidase inhibitors for the treatment of cardiovascular diseases in patients suffering from myeloproliferative neoplasms |
| KR20220088699A (ko) | 2019-09-27 | 2022-06-28 | 디스크 메디슨, 인크. | 골수섬유증 및 관련 상태의 치료 방법 |
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| WO2022125670A1 (en) | 2020-12-08 | 2022-06-16 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of vitiligo |
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- 2012-02-17 CA CA2827673A patent/CA2827673C/en active Active
- 2012-02-17 CN CN201280009417.3A patent/CN103732226B/zh active Active
- 2012-02-17 EA EA201391208A patent/EA026317B1/ru unknown
- 2012-02-17 KR KR1020137024424A patent/KR102024948B1/ko active Active
- 2012-02-17 MX MX2013009351A patent/MX357939B/es active IP Right Grant
- 2012-02-17 BR BR112013020798-1A patent/BR112013020798B1/pt active IP Right Grant
- 2012-02-17 AU AU2012219395A patent/AU2012219395B2/en active Active
- 2012-02-17 WO PCT/US2012/025581 patent/WO2012112847A1/en not_active Ceased
- 2012-02-17 US US13/399,274 patent/US9993480B2/en active Active
- 2012-02-17 EP EP12705608.3A patent/EP2675451B9/en active Active
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- 2012-02-17 JP JP2013554626A patent/JP5936628B2/ja active Active
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