JP2017530984A5 - - Google Patents
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- JP2017530984A5 JP2017530984A5 JP2017518802A JP2017518802A JP2017530984A5 JP 2017530984 A5 JP2017530984 A5 JP 2017530984A5 JP 2017518802 A JP2017518802 A JP 2017518802A JP 2017518802 A JP2017518802 A JP 2017518802A JP 2017530984 A5 JP2017530984 A5 JP 2017530984A5
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- 0 C*(C)NC(C1CC1)=O Chemical compound C*(C)NC(C1CC1)=O 0.000 description 9
- SMNAXTKCDCNAQG-YCHJVJMSSA-N CC(C)C(/C=C(/C(N(CC1)CC1c1nc(C)cc(C(C)C)c1)=O)\N)=N Chemical compound CC(C)C(/C=C(/C(N(CC1)CC1c1nc(C)cc(C(C)C)c1)=O)\N)=N SMNAXTKCDCNAQG-YCHJVJMSSA-N 0.000 description 1
- IDHXNQZUWRNLSI-OAJVMADHSA-N CC(C)C(/C=C(/C(N(CC1)CC1c1nc(C)cc(C2CCCC2)c1)=O)\N)=N Chemical compound CC(C)C(/C=C(/C(N(CC1)CC1c1nc(C)cc(C2CCCC2)c1)=O)\N)=N IDHXNQZUWRNLSI-OAJVMADHSA-N 0.000 description 1
- WWKQLKZHPMHBSM-UHFFFAOYSA-N CC(C)[n]1nc(cccc2)c2c1 Chemical compound CC(C)[n]1nc(cccc2)c2c1 WWKQLKZHPMHBSM-UHFFFAOYSA-N 0.000 description 1
- MPBYIDFVBMROTH-UHFFFAOYSA-N CC(C)[n]1ncc(c(F)c2)c1cc2Br Chemical compound CC(C)[n]1ncc(c(F)c2)c1cc2Br MPBYIDFVBMROTH-UHFFFAOYSA-N 0.000 description 1
- QYWHLIHVMLNPCM-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2cc(C)cc(C)n2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2cc(C)cc(C)n2)=O)c1 QYWHLIHVMLNPCM-UHFFFAOYSA-N 0.000 description 1
- ISYYMZGUNVIDIJ-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3C#N)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3C#N)c2)=O)c1 ISYYMZGUNVIDIJ-UHFFFAOYSA-N 0.000 description 1
- PSJNUJQXRJBICQ-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3Cl)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3Cl)c2)=O)c1 PSJNUJQXRJBICQ-UHFFFAOYSA-N 0.000 description 1
- JLUCSGYYDOSGIT-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cccc3)c3Cl)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cccc3)c3Cl)c2)=O)c1 JLUCSGYYDOSGIT-UHFFFAOYSA-N 0.000 description 1
- ADOPLAZEYVDBNR-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cccc3)c3OC)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c(cccc3)c3OC)c2)=O)c1 ADOPLAZEYVDBNR-UHFFFAOYSA-N 0.000 description 1
- NYBLIBCAYAWPIF-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](C(F)F)nc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](C(F)F)nc3)c2)=O)c1 NYBLIBCAYAWPIF-UHFFFAOYSA-N 0.000 description 1
- UWUKMXRNRWPXRV-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](C)cc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](C)cc3)c2)=O)c1 UWUKMXRNRWPXRV-UHFFFAOYSA-N 0.000 description 1
- ZMMWAYLSGNDHBJ-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](Cc4ccccc4)nc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[n](Cc4ccccc4)nc3)c2)=O)c1 ZMMWAYLSGNDHBJ-UHFFFAOYSA-N 0.000 description 1
- DKUQJFPELDXTEG-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[o]cc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[o]cc3)c2)=O)c1 DKUQJFPELDXTEG-UHFFFAOYSA-N 0.000 description 1
- AMLCZZBEFOGSRO-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[s]cc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3c[s]cc3)c2)=O)c1 AMLCZZBEFOGSRO-UHFFFAOYSA-N 0.000 description 1
- FHHZGVYBDCHFED-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cccc(C#N)c3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cccc(C#N)c3)c2)=O)c1 FHHZGVYBDCHFED-UHFFFAOYSA-N 0.000 description 1
- ZDEOCJBDKFWTIB-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cccc(Cl)c3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cccc(Cl)c3)c2)=O)c1 ZDEOCJBDKFWTIB-UHFFFAOYSA-N 0.000 description 1
- GYTIXMGHYWYHPM-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3ccccc3C)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3ccccc3C)c2)=O)c1 GYTIXMGHYWYHPM-UHFFFAOYSA-N 0.000 description 1
- JUGFUMWWAFDCJZ-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cnc(C)[s]3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cnc(C)[s]3)c2)=O)c1 JUGFUMWWAFDCJZ-UHFFFAOYSA-N 0.000 description 1
- CKMKMCGQKLICGJ-UHFFFAOYSA-N CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cnccc3)c2)=O)c1 Chemical compound CC(C)c1n[nH]c(C(N(CC2)CC2c2nc(C)cc(-c3cnccc3)c2)=O)c1 CKMKMCGQKLICGJ-UHFFFAOYSA-N 0.000 description 1
- JDIJRRHONXUUMY-BIAFCPFJSA-N CC(C)c1n[nH]c([C@@H](N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3OC)c2)[O]=C)c1 Chemical compound CC(C)c1n[nH]c([C@@H](N(CC2)CC2c2nc(C)cc(-c(cc3)ccc3OC)c2)[O]=C)c1 JDIJRRHONXUUMY-BIAFCPFJSA-N 0.000 description 1
- CJNWKQKFHSMHHI-UHFFFAOYSA-N CC(C1CNC1)=O Chemical compound CC(C1CNC1)=O CJNWKQKFHSMHHI-UHFFFAOYSA-N 0.000 description 1
- NGGWJGZAKJHKSZ-UHFFFAOYSA-N CC1C=CC(C(NC)=O)=CC1 Chemical compound CC1C=CC(C(NC)=O)=CC1 NGGWJGZAKJHKSZ-UHFFFAOYSA-N 0.000 description 1
- ZHJJLMNCPIHBRM-UHFFFAOYSA-N CC1C=Cc2n[n](C)cc2C1F Chemical compound CC1C=Cc2n[n](C)cc2C1F ZHJJLMNCPIHBRM-UHFFFAOYSA-N 0.000 description 1
- FJXRIACJPBCMCU-JOAIZHEFSA-O CCN/C=C(\C=[NH2+])/c1cc(C(CC2)CN2C(c2cc(C(C)C)n[nH]2)=O)nc(C)c1 Chemical compound CCN/C=C(\C=[NH2+])/c1cc(C(CC2)CN2C(c2cc(C(C)C)n[nH]2)=O)nc(C)c1 FJXRIACJPBCMCU-JOAIZHEFSA-O 0.000 description 1
- GQJXSYYQPWIJOU-ZNDRMEFZSA-N CCc1cc(C(CC2)CN2C(/C(/N)=C/C(C(C)C)=N)=O)nc(C)c1 Chemical compound CCc1cc(C(CC2)CN2C(/C(/N)=C/C(C(C)C)=N)=O)nc(C)c1 GQJXSYYQPWIJOU-ZNDRMEFZSA-N 0.000 description 1
- YCDDKKGCWDMJKY-SSDOTTSWSA-N CNC(C(C1)=CC=C[C@H]1I)=O Chemical compound CNC(C(C1)=CC=C[C@H]1I)=O YCDDKKGCWDMJKY-SSDOTTSWSA-N 0.000 description 1
- TZAYNGPUOOUEAP-UHFFFAOYSA-N C[n]1nc(C(F)(F)F)c(Br)c1 Chemical compound C[n]1nc(C(F)(F)F)c(Br)c1 TZAYNGPUOOUEAP-UHFFFAOYSA-N 0.000 description 1
- WQYAKZVLTOWKQB-UHFFFAOYSA-N C[n]1ncc(cc2)c1nc2Cl Chemical compound C[n]1ncc(cc2)c1nc2Cl WQYAKZVLTOWKQB-UHFFFAOYSA-N 0.000 description 1
- CSUGQXMRKOKBFI-UHFFFAOYSA-N C[n]1ncc2ccccc12 Chemical compound C[n]1ncc2ccccc12 CSUGQXMRKOKBFI-UHFFFAOYSA-N 0.000 description 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N O=Cc1ccccc1 Chemical compound O=Cc1ccccc1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014088309 | 2014-10-10 | ||
| CNPCT/CN2014/088309 | 2014-10-10 | ||
| PCT/US2015/054949 WO2016057924A1 (en) | 2014-10-10 | 2015-10-09 | Pyrrolidine amide compounds as histone demethylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530984A JP2017530984A (ja) | 2017-10-19 |
| JP2017530984A5 true JP2017530984A5 (enExample) | 2018-11-22 |
| JP6783230B2 JP6783230B2 (ja) | 2020-11-11 |
Family
ID=54337935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518802A Expired - Fee Related JP6783230B2 (ja) | 2014-10-10 | 2015-10-09 | ヒストンデメチラーゼのインヒビターとしてのピロリドンアミド化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10022354B2 (enExample) |
| EP (1) | EP3204379B1 (enExample) |
| JP (1) | JP6783230B2 (enExample) |
| CN (1) | CN107912040B (enExample) |
| WO (1) | WO2016057924A1 (enExample) |
Families Citing this family (62)
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| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
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Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| EP0491007B1 (en) | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| EP0659439B1 (en) | 1993-12-24 | 2001-10-24 | MERCK PATENT GmbH | Immunoconjugates |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| EP0772609B1 (en) | 1994-07-21 | 1999-02-24 | Akzo Nobel N.V. | Cyclic ketone peroxide formulations |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| DE122005000053I2 (de) | 1995-03-30 | 2008-01-17 | Pfizer Prod Inc | Chinazolinderivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| PT836605E (pt) | 1995-07-06 | 2002-07-31 | Novartis Ag | Pirrolopirimidinas e processos para a sua preparacao |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| US6344459B1 (en) | 1996-04-12 | 2002-02-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| ES2186908T3 (es) | 1996-07-13 | 2003-05-16 | Glaxo Group Ltd | Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas. |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU7165698A (en) | 1997-05-06 | 1998-11-27 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| HUP0004286A3 (en) | 1997-11-06 | 2002-01-28 | American Cyanamid Co Madison | Use of quinazoline derivatives for producing pharmaceutical compositions for treating colonic polyps |
| HUP0104211A3 (en) | 1998-11-19 | 2003-01-28 | Warner Lambert Co | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases and pharmaceutical composition containing it |
| JP5312466B2 (ja) * | 2008-10-02 | 2013-10-09 | 旭化成ファーマ株式会社 | ８位置換イソキノリン誘導体及びその用途 |
| EP2714662B1 (en) * | 2011-05-31 | 2017-10-11 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| MX2014013407A (es) * | 2012-05-22 | 2014-11-26 | Hoffmann La Roche | Dipiridilaminas sustituidas y uso de las mismas. |
| BR112015011148A8 (pt) * | 2012-11-16 | 2019-10-01 | Merck Sharp & Dohme | composto, composição farmacêutica, e combinação |
| US9738637B2 (en) * | 2013-03-12 | 2017-08-22 | Celgene Quantical Research, Inc. | Histone demethylase inhibitors |
| RU2015143517A (ru) * | 2013-03-13 | 2017-04-19 | Дженентек, Инк. | Пиразолсодержащие соединения и их применения |
-
2015
- 2015-10-09 CN CN201580066844.9A patent/CN107912040B/zh not_active Expired - Fee Related
- 2015-10-09 WO PCT/US2015/054949 patent/WO2016057924A1/en not_active Ceased
- 2015-10-09 JP JP2017518802A patent/JP6783230B2/ja not_active Expired - Fee Related
- 2015-10-09 EP EP15784257.6A patent/EP3204379B1/en active Active
-
2017
- 2017-04-07 US US15/482,584 patent/US10022354B2/en active Active
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