JP2019516759A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019516759A5 JP2019516759A5 JP2018561557A JP2018561557A JP2019516759A5 JP 2019516759 A5 JP2019516759 A5 JP 2019516759A5 JP 2018561557 A JP2018561557 A JP 2018561557A JP 2018561557 A JP2018561557 A JP 2018561557A JP 2019516759 A5 JP2019516759 A5 JP 2019516759A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- cycloalkyl
- arbitrary
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C([C@@](CC1)CN1c1cc2cccc(*)c2cn1)=O Chemical compound C*C([C@@](CC1)CN1c1cc2cccc(*)c2cn1)=O 0.000 description 2
- RKWSMOBCWOSVOU-UHFFFAOYSA-N CC(C)[n]1c(cccc2)c2c(-c2n[n](C)c(CC3)c2CN3C(C)=O)c1 Chemical compound CC(C)[n]1c(cccc2)c2c(-c2n[n](C)c(CC3)c2CN3C(C)=O)c1 RKWSMOBCWOSVOU-UHFFFAOYSA-N 0.000 description 1
- GSGFUJNUHRGDLF-UHFFFAOYSA-O CC(N(CC1)CC(C(c(c2c3ccnc2)ccc3F)=[NH2+])=C1NC1CCOCC1)=O Chemical compound CC(N(CC1)CC(C(c(c2c3ccnc2)ccc3F)=[NH2+])=C1NC1CCOCC1)=O GSGFUJNUHRGDLF-UHFFFAOYSA-O 0.000 description 1
- WZEAWVAERAAIEX-UHFFFAOYSA-O CC(N(CC1)CC(C(c(cc2)c(cncc3)c3c2Cl)=[NH2+])=C1NC1CCOCC1)=O Chemical compound CC(N(CC1)CC(C(c(cc2)c(cncc3)c3c2Cl)=[NH2+])=C1NC1CCOCC1)=O WZEAWVAERAAIEX-UHFFFAOYSA-O 0.000 description 1
- WIXFKVSMBGUBTA-IBGZPJMESA-N CC(N(CC1)CC(C(c2c(C)[nH]c3c2ccc(-c2c[n](C)nc2)c3)=N)=C1N[C@@H]1COCC1)=O Chemical compound CC(N(CC1)CC(C(c2c(C)[nH]c3c2ccc(-c2c[n](C)nc2)c3)=N)=C1N[C@@H]1COCC1)=O WIXFKVSMBGUBTA-IBGZPJMESA-N 0.000 description 1
- QSUIOQYCNLHTQS-RWENNGKJSA-N CC(N(CC1)CC(C(c2c(C)[nH]c3c2ccc(/C(/CN)=C/NC)c3)=N)=C1NC1COCC1)=O Chemical compound CC(N(CC1)CC(C(c2c(C)[nH]c3c2ccc(/C(/CN)=C/NC)c3)=N)=C1NC1COCC1)=O QSUIOQYCNLHTQS-RWENNGKJSA-N 0.000 description 1
- JHLUQWDELJFYRE-UHFFFAOYSA-O CC(N(CC1)CC(C(c2c(cnc(N3CCCC3)c3)c3ccc2)=[NH2+])=C1NC1CCOCC1)=O Chemical compound CC(N(CC1)CC(C(c2c(cnc(N3CCCC3)c3)c3ccc2)=[NH2+])=C1NC1CCOCC1)=O JHLUQWDELJFYRE-UHFFFAOYSA-O 0.000 description 1
- AGWQHAZGGMNEOF-UHFFFAOYSA-O CC(N(CC1)CC(C(c2c[nH]c(cc3)c2cc3-c2c[n](C)nc2)=[NH2+])=C1NC)=O Chemical compound CC(N(CC1)CC(C(c2c[nH]c(cc3)c2cc3-c2c[n](C)nc2)=[NH2+])=C1NC)=O AGWQHAZGGMNEOF-UHFFFAOYSA-O 0.000 description 1
- IWHQCMQFHRHPNR-UHFFFAOYSA-O CC(N(CC1)CC(C(c2cc(-c3c[n](C)nc3)ccc2)=[NH2+])=C1NC)=O Chemical compound CC(N(CC1)CC(C(c2cc(-c3c[n](C)nc3)ccc2)=[NH2+])=C1NC)=O IWHQCMQFHRHPNR-UHFFFAOYSA-O 0.000 description 1
- JKNCXBMKAJLWHN-UHFFFAOYSA-O CC(N(CC1)CC(C(c2ccc(C)c3c2cc[nH]3)=[NH2+])=C1NC)=O Chemical compound CC(N(CC1)CC(C(c2ccc(C)c3c2cc[nH]3)=[NH2+])=C1NC)=O JKNCXBMKAJLWHN-UHFFFAOYSA-O 0.000 description 1
- IXQWNXJLNOFSRE-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2-c(c1c2[nH]cc1)ccc2Cl)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2-c(c1c2[nH]cc1)ccc2Cl)=O IXQWNXJLNOFSRE-UHFFFAOYSA-N 0.000 description 1
- HWPHUYSBHLYXFP-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2cc(C(OC)=O)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2cc(C(OC)=O)c1)=O HWPHUYSBHLYXFP-UHFFFAOYSA-N 0.000 description 1
- RMTJHTPDLSMGNR-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2cc(OC)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2cc(OC)c1)=O RMTJHTPDLSMGNR-UHFFFAOYSA-N 0.000 description 1
- YAOPYMWNGQHROH-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C)nc2-c1c(cc[nH]2)c2ccc1)=O YAOPYMWNGQHROH-UHFFFAOYSA-N 0.000 description 1
- XGLAIMCDIMBGPK-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1c2ccnc1)ccc2OC)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1c2ccnc1)ccc2OC)=O XGLAIMCDIMBGPK-UHFFFAOYSA-N 0.000 description 1
- QRHSMFNSBKWHNZ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1cnc2)cccc1c2Cl)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1cnc2)cccc1c2Cl)=O QRHSMFNSBKWHNZ-UHFFFAOYSA-N 0.000 description 1
- GAVVBDXGDAIREU-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1cnc2)cccc1c2OC)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c(c1cnc2)cccc1c2OC)=O GAVVBDXGDAIREU-UHFFFAOYSA-N 0.000 description 1
- DXDMNVZXOSKMBM-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(C)[nH]c2c1cccc2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(C)[nH]c2c1cccc2)=O DXDMNVZXOSKMBM-UHFFFAOYSA-N 0.000 description 1
- VTCVXJOJHKXFNH-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(-c2c[n](C)nc2)c2)c2cc(C)c1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(-c2c[n](C)nc2)c2)c2cc(C)c1)=O VTCVXJOJHKXFNH-UHFFFAOYSA-N 0.000 description 1
- VCCZELIPLFSVQC-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(-c2c[n](C)nc2)c2)c2ccc1C)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(-c2c[n](C)nc2)c2)c2ccc1C)=O VCCZELIPLFSVQC-UHFFFAOYSA-N 0.000 description 1
- DJSHZSFSVVWRLV-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N(CC2)CC2C#N)c2)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N(CC2)CC2C#N)c2)c2ccc1)=O DJSHZSFSVVWRLV-UHFFFAOYSA-N 0.000 description 1
- MURDGIZINCTSAI-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N2CCCCC2)c2)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N2CCCCC2)c2)c2ccc1)=O MURDGIZINCTSAI-UHFFFAOYSA-N 0.000 description 1
- FXGWPWRNOMGUEL-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N2CCN(C)CC2)c2)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cnc(N2CCN(C)CC2)c2)c2ccc1)=O FXGWPWRNOMGUEL-UHFFFAOYSA-N 0.000 description 1
- UHNWSNQEYDVJCQ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cncc2)c2c(CO)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cncc2)c2c(CO)cc1)=O UHNWSNQEYDVJCQ-UHFFFAOYSA-N 0.000 description 1
- IZPACEJNRRRHNL-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cncc2C=C)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c(cncc2C=C)c2ccc1)=O IZPACEJNRRRHNL-UHFFFAOYSA-N 0.000 description 1
- VEGQMQNNMPHWTC-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c[nH]c2c1cccc2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c[nH]c2c1cccc2)=O VEGQMQNNMPHWTC-UHFFFAOYSA-N 0.000 description 1
- IUALVYSGFLFDGK-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c[n](C)c2c1cccc2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1c[n](C)c2c1cccc2)=O IUALVYSGFLFDGK-UHFFFAOYSA-N 0.000 description 1
- JEJLXAUUWSWJGH-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cc(Cl)cc2c1cnc(-c1c[n](C)nc1)c2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cc(Cl)cc2c1cnc(-c1c[n](C)nc1)c2)=O JEJLXAUUWSWJGH-UHFFFAOYSA-N 0.000 description 1
- YMJZTJARHXMQNO-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1ccc(C)c2c1cncc2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1ccc(C)c2c1cncc2)=O YMJZTJARHXMQNO-UHFFFAOYSA-N 0.000 description 1
- XJAYQWZRDYTMBJ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c(C)c(-c3c[n](C)nc3)ncc12)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c(C)c(-c3c[n](C)nc3)ncc12)=O XJAYQWZRDYTMBJ-UHFFFAOYSA-N 0.000 description 1
- HPNNACJOXIUFQN-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c(CO)cncc12)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c(CO)cncc12)=O HPNNACJOXIUFQN-UHFFFAOYSA-N 0.000 description 1
- YKJCGHAYZPQUNB-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c1[nH]cc2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1CCOCC1)nc2-c1cccc2c1[nH]cc2)=O YKJCGHAYZPQUNB-UHFFFAOYSA-N 0.000 description 1
- DBRHAVKKINQCFP-DLKOBCSISA-N CC(N(CC1)Cc2c1[n](C1COC1)nc2-c1c[nH]c2c1ccc(/C(/C=N)=C/NC)c2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COC1)nc2-c1c[nH]c2c1ccc(/C(/C=N)=C/NC)c2)=O DBRHAVKKINQCFP-DLKOBCSISA-N 0.000 description 1
- VJMYKALJTHINKT-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](C1COCC1)nc2-c1c[nH]c2c1ccc(-c1c[n](C)nc1)c2)=O Chemical compound CC(N(CC1)Cc2c1[n](C1COCC1)nc2-c1c[nH]c2c1ccc(-c1c[n](C)nc1)c2)=O VJMYKALJTHINKT-UHFFFAOYSA-N 0.000 description 1
- MPXKOIKIRQBXKT-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1c(cc[nH]2)c2ccc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1c(cc[nH]2)c2ccc1)=O MPXKOIKIRQBXKT-UHFFFAOYSA-N 0.000 description 1
- RWGXTFKQGCEQMJ-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1c[nH]c2c1cccc2)=O Chemical compound CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1c[nH]c2c1cccc2)=O RWGXTFKQGCEQMJ-UHFFFAOYSA-N 0.000 description 1
- YSSFCOVCRFYODP-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1ccc(C)c2c1cc[nH]2)=O Chemical compound CC(N(CC1)Cc2c1[n](CC1CC1)nc2-c1ccc(C)c2c1cc[nH]2)=O YSSFCOVCRFYODP-UHFFFAOYSA-N 0.000 description 1
- UEFJFQPLVYIOOV-SFHVURJKSA-N CC(N(CC1)Cc2c1[n]([C@@H]1COCC1)nc2-c1cccc2c1ccc(-c1c[n](C)nc1)n2)=O Chemical compound CC(N(CC1)Cc2c1[n]([C@@H]1COCC1)nc2-c1cccc2c1ccc(-c1c[n](C)nc1)n2)=O UEFJFQPLVYIOOV-SFHVURJKSA-N 0.000 description 1
- GHQQSOMXAFNIIX-UHFFFAOYSA-O CCc1c(cccc2C(C(CN(CC3)C(C)=O)=C3NC3CCOCC3)=[NH2+])c2cnc1 Chemical compound CCc1c(cccc2C(C(CN(CC3)C(C)=O)=C3NC3CCOCC3)=[NH2+])c2cnc1 GHQQSOMXAFNIIX-UHFFFAOYSA-O 0.000 description 1
- LDVUEFAKDIGXQX-UHFFFAOYSA-N CCc1ccc(-c2n[n](C3CCOCC3)c(CC3)c2CN3C(C)=O)c2c1ccnc2 Chemical compound CCc1ccc(-c2n[n](C3CCOCC3)c(CC3)c2CN3C(C)=O)c2c1ccnc2 LDVUEFAKDIGXQX-UHFFFAOYSA-N 0.000 description 1
- FAQWKGYIDUQQEE-UHFFFAOYSA-N CNC(N(CC1)Cc2c1[n](C1CCOCC1)c(C#N)c2C(CC=Cc1c2)c1cnc2-c1c[n](CCNC(N(CC2)Cc3c2[n](C2CCOCC2)nc3-c2c(CCCN(C3)c4c[n](C)nc4)c3ccc2)=O)nc1)=O Chemical compound CNC(N(CC1)Cc2c1[n](C1CCOCC1)c(C#N)c2C(CC=Cc1c2)c1cnc2-c1c[n](CCNC(N(CC2)Cc3c2[n](C2CCOCC2)nc3-c2c(CCCN(C3)c4c[n](C)nc4)c3ccc2)=O)nc1)=O FAQWKGYIDUQQEE-UHFFFAOYSA-N 0.000 description 1
- DRWVHZPKNZHPFP-UHFFFAOYSA-N COc(cc1)ccc1N(Cc1c2c(I)ccc1)C2=O Chemical compound COc(cc1)ccc1N(Cc1c2c(I)ccc1)C2=O DRWVHZPKNZHPFP-UHFFFAOYSA-N 0.000 description 1
- NZOVMAWNOOEQJP-UHFFFAOYSA-N C[n]1ncc(N(CCc(c2ccc3)c3[IH]C)C2=O)c1 Chemical compound C[n]1ncc(N(CCc(c2ccc3)c3[IH]C)C2=O)c1 NZOVMAWNOOEQJP-UHFFFAOYSA-N 0.000 description 1
- RZLGPVWNRCQORH-UHFFFAOYSA-N C[n]1ncc(N(Cc2ccccc2C2)C2=O)c1 Chemical compound C[n]1ncc(N(Cc2ccccc2C2)C2=O)c1 RZLGPVWNRCQORH-UHFFFAOYSA-N 0.000 description 1
- IPWVATCRLKASLP-UHFFFAOYSA-N Cc(c1ccc2)c(-c3c[n](C)nc3)ncc1c2-c1n[n](C2CCOCC2)c(CC2)c1CN2C(NC)=O Chemical compound Cc(c1ccc2)c(-c3c[n](C)nc3)ncc1c2-c1n[n](C2CCOCC2)c(CC2)c1CN2C(NC)=O IPWVATCRLKASLP-UHFFFAOYSA-N 0.000 description 1
- MQPVQCUKTCDLKI-UHFFFAOYSA-N Cc1c(CC(N(C)C2)=O)c2ccc1 Chemical compound Cc1c(CC(N(C)C2)=O)c2ccc1 MQPVQCUKTCDLKI-UHFFFAOYSA-N 0.000 description 1
- TZPZTDFDCDHPHG-UHFFFAOYSA-N Cc1cccc2c1cnc(-c(cc1)cnc1C(NC)=O)c2F Chemical compound Cc1cccc2c1cnc(-c(cc1)cnc1C(NC)=O)c2F TZPZTDFDCDHPHG-UHFFFAOYSA-N 0.000 description 1
- PSBDRZJULJXNAT-UHFFFAOYSA-N N#Cc1cc(NC(c2cccc(I)c2)=O)ccc1 Chemical compound N#Cc1cc(NC(c2cccc(I)c2)=O)ccc1 PSBDRZJULJXNAT-UHFFFAOYSA-N 0.000 description 1
- QRKLKNHKYLIORU-UHFFFAOYSA-N O=C(Cc1c(C2)cccc1I)N2C1CCCC1 Chemical compound O=C(Cc1c(C2)cccc1I)N2C1CCCC1 QRKLKNHKYLIORU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/083118 | 2016-05-24 | ||
| CN2016083118 | 2016-05-24 | ||
| PCT/US2017/034326 WO2017205538A1 (en) | 2016-05-24 | 2017-05-24 | Pyrazolopyridine derivatives for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516759A JP2019516759A (ja) | 2019-06-20 |
| JP2019516759A5 true JP2019516759A5 (enExample) | 2020-07-02 |
| JP7014736B2 JP7014736B2 (ja) | 2022-02-01 |
Family
ID=59055277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561557A Expired - Fee Related JP7014736B2 (ja) | 2016-05-24 | 2017-05-24 | がんの処置のためのピラゾロピリジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11247989B2 (enExample) |
| EP (1) | EP3464286B1 (enExample) |
| JP (1) | JP7014736B2 (enExample) |
| CN (1) | CN109476663B (enExample) |
| MA (1) | MA45146A (enExample) |
| WO (1) | WO2017205538A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CA3095367A1 (en) * | 2018-03-29 | 2019-10-03 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| WO2019195846A1 (en) | 2018-04-06 | 2019-10-10 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| CN110878042B (zh) * | 2018-09-05 | 2021-06-01 | 新发药业有限公司 | 一种n-取代基哌啶-3-酮的制备方法 |
| CN111320621B (zh) * | 2018-12-14 | 2022-10-04 | 中国科学院广州生物医药与健康研究院 | 一种吲嗪类化合物及其制备方法和应用 |
| EP3930759A4 (en) * | 2019-02-27 | 2023-03-22 | Cullgen (Shanghai), Inc. | CYCLIC AMP-RESPONSIVE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE |
| US20220135538A1 (en) * | 2019-02-27 | 2022-05-05 | Constellation Pharmaceuticals, Inc. | P300/cbp hat inhibitors and methods for their use |
| SG11202110714VA (en) * | 2019-04-09 | 2021-10-28 | Plexxikon Inc | Condensed azines for ep300 or cbp modulation and indications therefor |
| WO2021020363A1 (ja) | 2019-07-29 | 2021-02-04 | 武田薬品工業株式会社 | 複素環化合物 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| KR20220132592A (ko) * | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물 |
| CN111440161B (zh) * | 2020-05-15 | 2023-04-14 | 中国药科大学 | 一种具有par4拮抗活性的二环杂芳基类化合物及其应用 |
| CN111819574B (zh) * | 2020-06-10 | 2024-04-16 | 北京小米移动软件有限公司 | 生物特征的验证方法及装置、电子设备及存储介质 |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| IL299612A (en) | 2020-07-02 | 2023-03-01 | Incyte Corp | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| CN112079826B (zh) * | 2020-09-17 | 2022-07-29 | 广州中医药大学(广州中医药研究院) | 一类甾体合成酶抑制剂及其治疗应用 |
| WO2022093817A1 (en) * | 2020-10-26 | 2022-05-05 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| JPWO2022138944A1 (enExample) * | 2020-12-25 | 2022-06-30 | ||
| US11958861B2 (en) | 2021-02-25 | 2024-04-16 | Incyte Corporation | Spirocyclic lactams as JAK2 V617F inhibitors |
| AU2022380979A1 (en) | 2021-11-02 | 2024-06-06 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
| AU2022386486A1 (en) | 2021-11-12 | 2024-05-09 | Insilico Medicine Ip Limited | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
| EP4493558A1 (en) | 2022-03-17 | 2025-01-22 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| JP2025524870A (ja) | 2022-07-18 | 2025-08-01 | Jsr株式会社 | α，β不飽和カルボニル化合物およびそれらの中間体の光触媒合成 |
| US20240109868A1 (en) * | 2022-08-29 | 2024-04-04 | Miracure Biotechnology Limited | Ep300/cbp modulator, preparation method therefor and use thereof |
| CN115710249B (zh) * | 2022-11-14 | 2024-11-19 | 广东工业大学 | 一种多取代异喹啉和1,6-萘啶化合物的制备方法及光电材料常见分子骨架 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| DE69025946T2 (de) | 1989-09-08 | 1996-10-17 | Univ Duke | Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| ATE207366T1 (de) | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| ATE176910T1 (de) | 1994-07-21 | 1999-03-15 | Akzo Nobel Nv | Zyklische keton peroxyde zubereitungen |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| EP0817775B1 (en) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| ATE212993T1 (de) | 1995-07-06 | 2002-02-15 | Novartis Erfind Verwalt Gmbh | Pyrolopyrimidine und verfahren zu ihrer herstellung |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| EP0892789B2 (en) | 1996-04-12 | 2009-11-18 | Warner-Lambert Company LLC | Irreversible inhibitors of tyrosine kinases |
| AR007857A1 (es) | 1996-07-13 | 1999-11-24 | Glaxo Group Ltd | Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen. |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU7165698A (en) | 1997-05-06 | 1998-11-27 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| CN1278176A (zh) | 1997-11-06 | 2000-12-27 | 美国氰胺公司 | 喹唑啉衍生物作为用于治疗结肠息肉的酪氨酸激酶抑制剂的应用 |
| EA003786B1 (ru) | 1998-11-19 | 2003-10-30 | Варнер Ламберт Компани | N-[4-(3-хлор-4-фторфениламино)-7-(3-морфолин-4-илпропокси)хиназолин-6-ил]акриламид - необратимый ингибитор тирозинкиназ |
| CA2493625A1 (en) | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| MXPA05000945A (es) | 2002-07-25 | 2005-05-16 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de la cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |
| JP2006519816A (ja) | 2003-03-11 | 2006-08-31 | ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ | キナーゼ阻害剤として活性なビシクロピラゾール誘導体、それらの製造方法、及びそれらを含んでなる医薬組成物 |
| JP4361545B2 (ja) | 2005-05-09 | 2009-11-11 | 小野薬品工業株式会社 | ＰｒｏｇｒａｍｍｅｄＤｅａｔｈ１（ＰＤ−１）に対するヒトモノクローナル抗体および抗ＰＤ−１抗体単独または他の免疫療法と併用した癌治療方法 |
| HRP20151102T1 (xx) | 2005-07-01 | 2015-11-20 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1) |
| JP5219150B2 (ja) | 2005-12-12 | 2013-06-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害薬として活性な置換ピラゾロ［４，３−ｃ］ピリジン誘導体 |
| WO2007099166A1 (en) | 2006-03-03 | 2007-09-07 | Nerviano Medical Sciences S.R.L. | Pyrazolo-pyridine derivatives active as kinase inhibitors |
| KR101600634B1 (ko) | 2007-12-28 | 2016-03-07 | 미쓰비시 타나베 파마 코퍼레이션 | 항암제 |
| CA2715166C (en) | 2008-02-11 | 2017-05-16 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CL2009001158A1 (es) | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
| WO2009158394A1 (en) * | 2008-06-25 | 2009-12-30 | Bristol-Myers Squibb Company | Diketo azolopiperidines and azolopiperazines as anti-hiv agents |
| JP2012510429A (ja) | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Ｐｄ−１アンタゴニストおよびその使用方法 |
| KR20250091300A (ko) | 2008-12-09 | 2025-06-20 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| CN101812063B (zh) | 2010-03-18 | 2012-04-25 | 中国医学科学院医药生物技术研究所 | α-萘磺酰胺基五元杂环类化合物及其抑瘤活性 |
| JP5893143B2 (ja) * | 2011-09-12 | 2016-03-23 | サノフイ | インダニル置換の４，５，６，７−テトラヒドロ−１Ｈ−ピラゾロ［４，３−ｃ］ピリジン、医薬としてのその使用、及びそれらを含む医薬製剤 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| WO2013148114A1 (en) | 2012-03-30 | 2013-10-03 | University Of Florida Research Foundation, Inc. | P300/cbp inhibitors and methods of use |
| WO2014138727A1 (en) | 2013-03-08 | 2014-09-12 | Board Of Regents, The University Of Texas System | Suppression of malignant mesothelioma by overexpression or stimulation of endothelial protein c receptors (epcr) |
| EP2993174A1 (en) * | 2014-09-08 | 2016-03-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Pyrazolopyridine derivatives and their use in therapy |
| US9763922B2 (en) | 2014-11-27 | 2017-09-19 | Genentech, Inc. | Therapeutic compounds and uses thereof |
-
2017
- 2017-05-24 EP EP17729963.3A patent/EP3464286B1/en active Active
- 2017-05-24 MA MA045146A patent/MA45146A/fr unknown
- 2017-05-24 JP JP2018561557A patent/JP7014736B2/ja not_active Expired - Fee Related
- 2017-05-24 WO PCT/US2017/034326 patent/WO2017205538A1/en not_active Ceased
- 2017-05-24 CN CN201780045658.6A patent/CN109476663B/zh active Active
-
2018
- 2018-11-21 US US16/198,581 patent/US11247989B2/en active Active
-
2022
- 2022-01-06 US US17/570,139 patent/US20220127265A1/en not_active Abandoned