JP2017530176A5 - - Google Patents
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- JP2017530176A5 JP2017530176A5 JP2017518804A JP2017518804A JP2017530176A5 JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5 JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- group
- independently selected
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| WO2016077375A1 (en) * | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| IL287136B2 (en) | 2016-02-05 | 2023-09-01 | Denali Therapeutics Inc | Receptor inhibitors - interacting with protein kinase 1 |
| JP7160688B2 (ja) * | 2016-05-24 | 2022-10-25 | ジェネンテック， インコーポレイテッド | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
| CN109715790A (zh) | 2016-07-25 | 2019-05-03 | 埃皮兹姆公司 | Crebbp相关的癌症疗法 |
| HUE058802T2 (hu) | 2016-12-09 | 2022-09-28 | Denali Therapeutics Inc | RIPK1 inhibitorokként alkalmas vegyületek |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| CN107325092B (zh) * | 2017-08-07 | 2021-01-08 | 山东鲁宁药业有限公司 | 一种阿奇沙坦的制备新工艺 |
| CN107643405B (zh) * | 2017-09-19 | 2020-07-17 | 上海市肺科医院 | 一种基于自身抗体检测的肺癌诊断试剂盒及其应用 |
| WO2019070742A1 (en) * | 2017-10-03 | 2019-04-11 | Sidecar Therapeutics, Inc. | APOPTOSIS SIGNAL REGULATION KINASE 1 (ASK 1) INHIBITORS COMPOUNDS |
| BR112020019824A2 (pt) | 2018-03-29 | 2021-01-05 | Board Of Regents, The University Of Texas System | Composto de fórmula estrutural i ou um sal do mesmo, composição farmacêutica, método de inibição de cbp, método de inibição de p300, método de tratamento de uma doença mediada por cbp, método de tratamento de uma doença mediada por p300 e método para alcançar um efeito em um paciente |
| WO2019195846A1 (en) | 2018-04-06 | 2019-10-10 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| TWI850342B (zh) * | 2019-02-27 | 2024-08-01 | 美商星座製藥公司 | P300/cbp hat抑制劑及其使用方法 |
| CN119330963A (zh) * | 2019-02-27 | 2025-01-21 | 上海睿跃生物科技有限公司 | 环amp反应元件结合蛋白(cbp)和/或300kda腺病毒e1a结合蛋白(p300)降解化合物和使用方法 |
| AU2020257301B2 (en) | 2019-04-18 | 2025-10-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
| AU2020295399B2 (en) * | 2019-06-18 | 2025-10-16 | Dana-Farber Cancer Institute, Inc. | Small molecule target bromo/acetyl proteins and uses thereof |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| US12486251B2 (en) | 2020-04-25 | 2025-12-02 | Pharmablock Sciences (Nanjing) , Inc. | CBP/EP300 inhibitor and use thereof |
| CA3177830A1 (en) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| BR112022024729A2 (pt) | 2020-06-05 | 2023-02-28 | Kinnate Biopharma Inc | Inibidores de quinases do receptor do fator de crescimento de fibroblastos |
| US20230250088A1 (en) * | 2020-07-15 | 2023-08-10 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| AU2021355480B2 (en) | 2020-10-02 | 2026-03-05 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| EP4221708A4 (en) | 2020-10-02 | 2024-11-06 | Board of Regents, The University of Texas System | IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION-ACTIVATING PROTEINS |
| EP4277897A1 (en) * | 2021-01-12 | 2023-11-22 | Chengdu Anticancer Bioscience, Ltd. | Fused azepine compounds and their use in the treatment of cancer |
| WO2022226172A1 (en) * | 2021-04-21 | 2022-10-27 | The Regents Of The University Of California | Compositions and methods for treating neurodegenerative diseases |
| US20240239768A1 (en) * | 2021-04-27 | 2024-07-18 | Lg Chem, Ltd. | Method for preparing xanthine oxidase inhibitor |
| TW202317087A (zh) | 2021-08-10 | 2023-05-01 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關病況之化合物及組合物 |
| AU2022393879A1 (en) * | 2021-11-19 | 2024-05-23 | Chengdu Anticancer Bioscience, Ltd. | 1h-benzo[b]azepin-2(3h)-one compounds, compositions and methods of treating cancer |
| US11999750B2 (en) | 2022-01-12 | 2024-06-04 | Denali Therapeutics Inc. | Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide |
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| US3203952A (en) * | 1962-12-04 | 1965-08-31 | Upjohn Co | Chloromethylsulfonamides of cyclic diamines |
| US3361750A (en) * | 1963-03-21 | 1968-01-02 | Squibb & Sons Inc | Benzothiazepines |
| DE3800386A1 (de) * | 1988-01-09 | 1989-07-20 | Bayer Ag | Verfahren zur herstellung von benzothiazepinon-derivaten |
| JPWO2006051851A1 (ja) * | 2004-11-10 | 2008-05-29 | わかもと製薬株式会社 | ２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン誘導体、及び、医薬組成物 |
| DE102006051796A1 (de) * | 2006-11-03 | 2008-05-08 | Merck Patent Gmbh | Triaza-benzo[e]azulenderivate |
| WO2012151512A2 (en) * | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI530499B (zh) * | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域（ｂｒｏｍｏｄｏｍａｉｎ）抑制劑之苯並咪唑酮衍生物類 |
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