JP2017530176A5 - - Google Patents
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- JP2017530176A5 JP2017530176A5 JP2017518804A JP2017518804A JP2017530176A5 JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5 JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- group
- independently selected
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| WO2016077375A1 (en) * | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| SG11201806302RA (en) | 2016-02-05 | 2018-08-30 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
| JP7160688B2 (ja) * | 2016-05-24 | 2022-10-25 | ジェネンテック， インコーポレイテッド | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
| CA3031525A1 (en) | 2016-07-25 | 2018-02-01 | Epizyme, Inc. | Crebbp related cancer therapy |
| LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CN107325092B (zh) * | 2017-08-07 | 2021-01-08 | 山东鲁宁药业有限公司 | 一种阿奇沙坦的制备新工艺 |
| CN107643405B (zh) * | 2017-09-19 | 2020-07-17 | 上海市肺科医院 | 一种基于自身抗体检测的肺癌诊断试剂盒及其应用 |
| WO2019070742A1 (en) * | 2017-10-03 | 2019-04-11 | Sidecar Therapeutics, Inc. | APOPTOSIS SIGNAL REGULATION KINASE 1 (ASK 1) INHIBITORS COMPOUNDS |
| AU2019245403B2 (en) | 2018-03-29 | 2025-02-06 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| US10899769B2 (en) | 2018-04-06 | 2021-01-26 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| WO2020173440A1 (en) * | 2019-02-27 | 2020-09-03 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
| CA3131383A1 (en) * | 2019-02-27 | 2020-09-03 | Constellation Pharmaceuticals, Inc. | P300/cbp hat inhibitors and methods for their use |
| US20230086702A1 (en) | 2019-04-18 | 2023-03-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a]pyridine derivatives and use thereof |
| CN114007652A (zh) | 2019-06-18 | 2022-02-01 | 达纳-法伯癌症研究公司 | 小分子靶向溴/乙酰蛋白及其用途 |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| AU2021259814B2 (en) * | 2020-04-25 | 2023-09-28 | Pharmablock Sciences (Nanjing), Inc. | CBP/EP300 inhibitor and use thereof |
| AU2021270458A1 (en) | 2020-05-13 | 2022-11-10 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating myelofibrosis |
| TW202210472A (zh) | 2020-06-05 | 2022-03-16 | 美商奇奈特生物製藥公司 | 纖維母細胞生長因子受體激酶之抑制劑 |
| US20230250088A1 (en) * | 2020-07-15 | 2023-08-10 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20240270695A1 (en) * | 2021-01-12 | 2024-08-15 | Chengdu Anticancer Bioscience Ltd | Compounds, compositions and methods of treating disorders |
| EP4326712A4 (en) * | 2021-04-21 | 2025-03-05 | The Regents of The University of California | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES |
| WO2022231262A1 (ko) * | 2021-04-27 | 2022-11-03 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제의 제조 방법 |
| WO2023088420A1 (en) * | 2021-11-19 | 2023-05-25 | Chengdu Anticancer Bioscience, Ltd. | 1h-benzo[b]azepin-2(3h)-one compounds, compositions and methods of treating cancer |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
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| US3203952A (en) * | 1962-12-04 | 1965-08-31 | Upjohn Co | Chloromethylsulfonamides of cyclic diamines |
| US3361750A (en) * | 1963-03-21 | 1968-01-02 | Squibb & Sons Inc | Benzothiazepines |
| DE3800386A1 (de) * | 1988-01-09 | 1989-07-20 | Bayer Ag | Verfahren zur herstellung von benzothiazepinon-derivaten |
| WO2006051851A1 (ja) * | 2004-11-10 | 2006-05-18 | Wakamoto Pharmaceutical Co., Ltd. | ２，３，４，５－テトラヒドロ－１ｈ－１，５－ベンゾジアゼピン誘導体、及び、医薬組成物 |
| DE102006051796A1 (de) * | 2006-11-03 | 2008-05-08 | Merck Patent Gmbh | Triaza-benzo[e]azulenderivate |
| EP2705039B1 (en) * | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI530499B (zh) * | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域（ｂｒｏｍｏｄｏｍａｉｎ）抑制劑之苯並咪唑酮衍生物類 |
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