JP2017530176A5 - - Google Patents
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- JP2017530176A5 JP2017530176A5 JP2017518804A JP2017518804A JP2017530176A5 JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5 JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017518804 A JP2017518804 A JP 2017518804A JP 2017530176 A5 JP2017530176 A5 JP 2017530176A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- group
- independently selected
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| EP3218376B1 (en) * | 2014-11-10 | 2019-12-25 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| MX2018009448A (es) | 2016-02-05 | 2018-11-21 | Denali Therapeutics Inc | Inhibidores de proteina quinasa 1 de interaccion con receptores. |
| MA45122A (fr) * | 2016-05-24 | 2019-04-10 | Constellation Pharmaceuticals Inc | Inhibiteurs hétérocycliques de cbp/ep300 et leur utilisation dans le traitement du cancer |
| WO2018022637A1 (en) | 2016-07-25 | 2018-02-01 | Epizyme, Inc. | Crebbp related cancer therapy |
| ES2912295T3 (es) | 2016-12-09 | 2022-05-25 | Denali Therapeutics Inc | Compuestos útiles como inhibidores de RIPK1 |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| CN107325092B (zh) * | 2017-08-07 | 2021-01-08 | 山东鲁宁药业有限公司 | 一种阿奇沙坦的制备新工艺 |
| CN107643405B (zh) * | 2017-09-19 | 2020-07-17 | 上海市肺科医院 | 一种基于自身抗体检测的肺癌诊断试剂盒及其应用 |
| WO2019070742A1 (en) * | 2017-10-03 | 2019-04-11 | Sidecar Therapeutics, Inc. | APOPTOSIS SIGNAL REGULATION KINASE 1 (ASK 1) INHIBITORS COMPOUNDS |
| KR102815607B1 (ko) | 2018-03-29 | 2025-05-30 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전사 활성화 단백질의 이미다조피페라진 억제제 |
| US10899769B2 (en) | 2018-04-06 | 2021-01-26 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| EP3930759A4 (en) * | 2019-02-27 | 2023-03-22 | Cullgen (Shanghai), Inc. | CYCLIC AMP-RESPONSIVE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE |
| ES2989353T3 (es) * | 2019-02-27 | 2024-11-26 | Constellation Pharmaceuticals Inc | Derivados de N-(piridinil)acetamida como inhibidores de HAT P300/CBP y métodos para su uso |
| WO2020215094A1 (en) | 2019-04-18 | 2020-10-22 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof |
| CA3143507A1 (en) | 2019-06-18 | 2020-12-24 | Dana-Farber Cancer Institute, Inc. | Small molecule target bromo/acetyl proteins and uses thereof |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| AU2020356575A1 (en) | 2019-09-27 | 2022-04-14 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| EP4140996A4 (en) * | 2020-04-25 | 2024-04-24 | Pharmablock Sciences (Nanjing), Inc. | CBP/EP300 INHIBITOR AND USE THEREOF |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| BR112022024729A2 (pt) | 2020-06-05 | 2023-02-28 | Kinnate Biopharma Inc | Inibidores de quinases do receptor do fator de crescimento de fibroblastos |
| WO2022015938A1 (en) * | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20240270695A1 (en) * | 2021-01-12 | 2024-08-15 | Chengdu Anticancer Bioscience Ltd | Compounds, compositions and methods of treating disorders |
| US20240208935A1 (en) * | 2021-04-21 | 2024-06-27 | The Regents Of The University Of California | Compositions and methods for treating neurodegenerative diseases |
| KR20220147531A (ko) * | 2021-04-27 | 2022-11-03 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제의 제조 방법 |
| MX2024001817A (es) | 2021-08-10 | 2024-05-03 | Ifm Due Inc | Compuestos y composiciones para tratar condiciones asociadas con actividad de sting. |
| AU2022393879A1 (en) * | 2021-11-19 | 2024-05-23 | Chengdu Anticancer Bioscience, Ltd. | 1h-benzo[b]azepin-2(3h)-one compounds, compositions and methods of treating cancer |
| US11999750B2 (en) | 2022-01-12 | 2024-06-04 | Denali Therapeutics Inc. | Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide |
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| US3203952A (en) * | 1962-12-04 | 1965-08-31 | Upjohn Co | Chloromethylsulfonamides of cyclic diamines |
| US3361750A (en) * | 1963-03-21 | 1968-01-02 | Squibb & Sons Inc | Benzothiazepines |
| DE3800386A1 (de) * | 1988-01-09 | 1989-07-20 | Bayer Ag | Verfahren zur herstellung von benzothiazepinon-derivaten |
| US20080076760A1 (en) * | 2004-11-10 | 2008-03-27 | Wakamoto Pharmaceutical Co., Ltd | 2,3,4,5-tetrahydro-1h-1,5-benzodiazepine derivative and medicinal composition |
| DE102006051796A1 (de) * | 2006-11-03 | 2008-05-08 | Merck Patent Gmbh | Triaza-benzo[e]azulenderivate |
| EP2705039B1 (en) * | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI530499B (zh) * | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域（ｂｒｏｍｏｄｏｍａｉｎ）抑制劑之苯並咪唑酮衍生物類 |
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