CN107108512B - 治疗性化合物及其用途 - Google Patents
治疗性化合物及其用途 Download PDFInfo
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- CN107108512B CN107108512B CN201580066923.XA CN201580066923A CN107108512B CN 107108512 B CN107108512 B CN 107108512B CN 201580066923 A CN201580066923 A CN 201580066923A CN 107108512 B CN107108512 B CN 107108512B
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/088315 | 2014-10-10 | ||
| CN2014088315 | 2014-10-10 | ||
| PCT/CN2015/091614 WO2016055028A1 (en) | 2014-10-10 | 2015-10-10 | Therapeutic compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107108512A CN107108512A (zh) | 2017-08-29 |
| CN107108512B true CN107108512B (zh) | 2021-05-04 |
Family
ID=55652608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580066923.XA Active CN107108512B (zh) | 2014-10-10 | 2015-10-10 | 治疗性化合物及其用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10206931B2 (enExample) |
| EP (1) | EP3204360B1 (enExample) |
| JP (1) | JP6820254B2 (enExample) |
| CN (1) | CN107108512B (enExample) |
| WO (1) | WO2016055028A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3218376B1 (en) * | 2014-11-10 | 2019-12-25 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| TWI781920B (zh) | 2016-02-05 | 2022-11-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| WO2017205536A2 (en) * | 2016-05-24 | 2017-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| EP3487993A1 (en) | 2016-07-25 | 2019-05-29 | Epizyme, Inc. | Crebbp related cancer therapy |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| CN107325092B (zh) * | 2017-08-07 | 2021-01-08 | 山东鲁宁药业有限公司 | 一种阿奇沙坦的制备新工艺 |
| CN107643405B (zh) * | 2017-09-19 | 2020-07-17 | 上海市肺科医院 | 一种基于自身抗体检测的肺癌诊断试剂盒及其应用 |
| WO2019070742A1 (en) * | 2017-10-03 | 2019-04-11 | Sidecar Therapeutics, Inc. | APOPTOSIS SIGNAL REGULATION KINASE 1 (ASK 1) INHIBITORS COMPOUNDS |
| JP7387627B2 (ja) | 2018-03-29 | 2023-11-28 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | 転写活性化タンパク質のイミダゾピペラジン阻害剤 |
| US10899769B2 (en) | 2018-04-06 | 2021-01-26 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| JP7638880B2 (ja) * | 2019-02-27 | 2025-03-04 | コンステレーション・ファーマシューティカルズ・インコーポレイテッド | P300/cbp hat阻害剤及びその使用方法 |
| US20230073777A1 (en) * | 2019-02-27 | 2023-03-09 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
| AU2020257301B2 (en) | 2019-04-18 | 2025-10-23 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
| WO2020257278A2 (en) * | 2019-06-18 | 2020-12-24 | Dana-Farber Cancer Institute, Inc. | Small molecule target bromo/acetyl proteins and uses thereof |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| EP4140996A4 (en) * | 2020-04-25 | 2024-04-24 | Pharmablock Sciences (Nanjing), Inc. | CBP/EP300 INHIBITOR AND USE THEREOF |
| EP4149548A4 (en) | 2020-05-13 | 2024-05-08 | Disc Medicine, Inc. | ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS |
| BR112022024729A2 (pt) | 2020-06-05 | 2023-02-28 | Kinnate Biopharma Inc | Inibidores de quinases do receptor do fator de crescimento de fibroblastos |
| WO2022015938A1 (en) * | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN116710442A (zh) * | 2021-01-12 | 2023-09-05 | 成都安泰康赛生物科技有限公司 | 治疗病症的化合物、组合物和方法 |
| US20240208935A1 (en) * | 2021-04-21 | 2024-06-27 | The Regents Of The University Of California | Compositions and methods for treating neurodegenerative diseases |
| WO2022231262A1 (ko) * | 2021-04-27 | 2022-11-03 | 주식회사 엘지화학 | 잔틴 옥시다아제 저해제의 제조 방법 |
| CA3237762A1 (en) * | 2021-11-19 | 2023-05-25 | Dun Yang | 1h-benzo[b]azepin-2(3h)-one compounds, compositions and methods of treating cancer |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
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- 2015-10-10 EP EP15848282.8A patent/EP3204360B1/en active Active
- 2015-10-10 JP JP2017518804A patent/JP6820254B2/ja not_active Expired - Fee Related
- 2015-10-10 WO PCT/CN2015/091614 patent/WO2016055028A1/en not_active Ceased
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2017
- 2017-04-07 US US15/482,581 patent/US10206931B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20170312292A1 (en) | 2017-11-02 |
| US10206931B2 (en) | 2019-02-19 |
| CN107108512A (zh) | 2017-08-29 |
| EP3204360B1 (en) | 2020-08-26 |
| EP3204360A1 (en) | 2017-08-16 |
| JP2017530176A (ja) | 2017-10-12 |
| WO2016055028A1 (en) | 2016-04-14 |
| EP3204360A4 (en) | 2018-03-28 |
| HK1243073A1 (zh) | 2018-07-06 |
| JP6820254B2 (ja) | 2021-01-27 |
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